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学科主题临床医学
Impact of variants of the EXT2 gene on Type 2 diabetes and its related traits in the Chinese han population
Ren, Qian1; Xiao, Jianzhong2; Han, Xueyao1; Yang, Wenying2; Ji, Linong1
关键词Beta-cell function diabetes EXT2
刊名ENDOCRINE RESEARCH
2015
DOI10.3109/07435800.2014.952015
40期:2页:79-82
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]GENOME-WIDE ASSOCIATION ; INSULIN SENSITIVITY ; GLUCOSE-TOLERANCE ; RISK LOCI ; PREVENTION ; IGF2BP2 ; CDKAL1 ; HHEX ; CELL
英文摘要

Purpose/Aim of the study: Exostosin 2 (EXT2) is involved in early pancreatic development and the regulation of insulin synthesis. In this study, we aim to evaluate the contribution of EXT2 to the genetic pathogenesis of type 2 diabetes and its related traits in the Chinese population. Materials and methods: A case-control study in a Chinese Han population was conducted that included 4766 patients with type 2 diabetes and 4596 control subjects from 14 different regions of China. Three single nucleotide polymorphism (SNP), rs3740878, rs11037909 and rs1113132, in the EXT2 gene were genotyped using the Illumina GoldenGate Genotyping assay. Results: After adjusting for sex, age and body mass index, logistic regression analysis revealed that the EXT2 gene had no association with type 2 diabetes using an additive genetic model [rs3740878 (Odds Ratio (OR) = 0.996, 95% confidence interval (CI) 0.928-1.069, p = 0.910), rs11037909 (OR = 1.003, 95% CI 0.933-1.078, p = 0.931), and rs1113132 (OR = 0.993, 95% CI 0.925-1.065, p = 0.842)]. None of these SNPs were associated with beta cell function as determined using the baseline disposition index, early phase insulin secretion and Oral Glucose Tolerance Test (OGTT) total disposition index. Conclusions: Our study suggests that the EXT2 gene might not have a major role in the development of type 2 diabetes in the Chinese population.

语种英语
WOS记录号WOS:000354404300004
项目编号2011CB504001 ; 2012AA02A509
资助机构China Medical Association Research Fund ; National Basic Research Program of China (973 program) ; National High Technology Research and Development Program of China (863 Program)
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63616
专题北京大学第二临床医学院
北京大学第二临床医学院_内分泌科
作者单位1.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Ctr Diabet, Beijing 100044, Peoples R China
2.China Japan Friendship Hosp, Dept Endocrinol & Metab, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Ren, Qian,Xiao, Jianzhong,Han, Xueyao,et al. Impact of variants of the EXT2 gene on Type 2 diabetes and its related traits in the Chinese han population[J]. ENDOCRINE RESEARCH,2015,40(2):79-82.
APA Ren, Qian,Xiao, Jianzhong,Han, Xueyao,Yang, Wenying,&Ji, Linong.(2015).Impact of variants of the EXT2 gene on Type 2 diabetes and its related traits in the Chinese han population.ENDOCRINE RESEARCH,40(2),79-82.
MLA Ren, Qian,et al."Impact of variants of the EXT2 gene on Type 2 diabetes and its related traits in the Chinese han population".ENDOCRINE RESEARCH 40.2(2015):79-82.
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