IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Frequent mtDNA mutations and its role in gastric carcinogenesis
Liu, MR; Lu, YY
关键词mtDNA human gastric cancer gene mutation DHPLC gastric carcinogenesis
刊名CHINESE SCIENCE BULLETIN
2002-10-01
47期:20页:1720-1724
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]MITOCHONDRIAL-DNA MUTATIONS ; MICROSATELLITE INSTABILITY ; CONTROL REGION ; BODILY FLUIDS ; TUMORS ; CARCINOMA ; CANCERS ; DIAGNOSIS ; BREAST
英文摘要

in order to disclose the relationship between mutations of mitochondrial DNA (mtDNA) and gastric carcinogenesis, we screened the entire mtDNA sequence in 30 cases of human gastric cancer and matched normal tissues by using denaturing high-performance liquid chromatography (DEPLC) and DNA sequencing. Our data showed that high frequency (66.7%, 20/30) of mitochondrial genome mutation occurred in gastric cancer. Among these variants, 17 cases (56.7%, 17/30) were identified to be somatic mutation. High level mutant frequency was found in ND4, ND5 coding genes and D-loop control region, which was 36.7%, 26.7% and 30% respectively. Comparing with complexes III, IV and V of the electron transport chain, we found that variants appeared to be more frequent in the subunit genes of complex I. Most of mutations were base substitutions (85.4%, 41/48). Our results suggested that mutations of subunit genes encoding complex I, especially ND3, ND4 and ND5 genes, might contribute to human gastric carcinogenesis.

语种英语
WOS记录号WOS:000178433900011
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63626
专题北京大学临床肿瘤学院
作者单位Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing Lab Mol Oncol, Beijing 100034, Peoples R China
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GB/T 7714
Liu, MR,Lu, YY. Frequent mtDNA mutations and its role in gastric carcinogenesis[J]. CHINESE SCIENCE BULLETIN,2002,47(20):1720-1724.
APA Liu, MR,&Lu, YY.(2002).Frequent mtDNA mutations and its role in gastric carcinogenesis.CHINESE SCIENCE BULLETIN,47(20),1720-1724.
MLA Liu, MR,et al."Frequent mtDNA mutations and its role in gastric carcinogenesis".CHINESE SCIENCE BULLETIN 47.20(2002):1720-1724.
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