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学科主题: 基础医学
题名:
Really interesting new gene finger protein 121 is a novel Golgi-localized membrane protein that regulates apoptosis
作者: Zhao, Yuanbo1,2; Hongdu, Beiqi1,2; Ma, Dalong1,2; Chen, Yingyu1,2
关键词: RING finger protein 121 ; apoptosis ; RING domain ; Golgi apparatus
刊名: ACTA BIOCHIMICA ET BIOPHYSICA SINICA
发表日期: 2014-08-01
DOI: 10.1093/abbs/gmu047
卷: 46, 期:8, 页:668-674
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: E3 UBIQUITIN LIGASE ; DEGRADATION ; EXPRESSION ; RESPONSES ; DEATH ; CELLS
英文摘要:

Really interesting new gene (RING) finger proteins represent a large protein family in the human genome, and play crucial roles in physiological activities and cancer development. The biological functions of some RING finger proteins remain unknown. Here, we described the biological activity of a novel, human Golgi-localized RING finger protein 121 (RNF121), the function of which is, thus far, unknown. Unlike the endoplasmic reticulum-localized RNF121 in Caenorhabditis elegans, human RNF121 is predominantly localized to the Golgi apparatus. RNF121 knockdown inhibited cell growth and induced apoptosis, which was accompanied by caspase-3 activation and the cleavage of poly (adenosine diphosphate-ribose) polymerase. Z-VAD-FMK, a pan-caspase inhibitor, inhibited the RNF121 knockdown-induced apoptosis. Over-expression of wild-type RNF121, but not the RING domain mutants of RNF121, decreased RNF121 knockdown-induced apoptosis, indicating that the RING domain is required for RNF121-regulated apoptosis. Moreover, RNF121 knockdown enhanced etoposide-induced apoptosis. This is the first study to demonstrate that RNF121 is a novel regulator of apoptosis and provides a new potential target for cancer therapy.

语种: 英语
所属项目编号: 2011CB910103
项目资助者: National Key Basic Research Program of China
WOS记录号: WOS:000340098200005
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63628
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Key Lab Med Immunol, Minist Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China

Recommended Citation:
Zhao, Yuanbo,Hongdu, Beiqi,Ma, Dalong,et al. Really interesting new gene finger protein 121 is a novel Golgi-localized membrane protein that regulates apoptosis[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2014,46(8):668-674.
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