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Coexistence of copy number increases of ZNF217 and CYP24A1 in colorectal cancers in a Chinese population
Fang, Zhengyu1,2; Xiong, Yi1,2; Zhang, Chao1,2; Li, Jiana1,2; Liu, Li1,2; Li, Manhui1,2; Zhang, Wei3; Wan, Jun1,2
关键词colorectal cancer zinc-finger protein 217 25-hydroxy vitamin D3 24-hydroxylase copy number variation
刊名ONCOLOGY LETTERS
2010-09-01
DOI10.3892/ol_00000163
1期:5页:925-930
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]COMPARATIVE GENOMIC HYBRIDIZATION ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; CANDIDATE ONCOGENE ZNF217 ; GENE-EXPRESSION ; PROSTATE-CANCER ; CHROMOSOME 20Q ; COLON-CANCER ; ASSOCIATION ; GAIN
英文摘要

Evidence suggests that the amplification of chromosome 20q13 is common in colorectal cancers (CRCs). Certain candidate oncogenes located in this region are reported to be associated with tumorigenesis of the gastrointestinal tract. The functional impact of such regions should be extensively investigated in a large number of clinical samples. In this study, 145 CRC samples with matched adjacent normal tissues were collected from a Chinese population for copy number variation (CNV) analysis. Our results showed that both the copy numbers of 25-hydroxy vitamin D3 24-hydroxylase (CYP24A1) and zinc-finger protein 217 (ZNF217) were amplified in a relatively high percentage of CRC samples (51.1 and 60%, respectively). The mRNA expression levels of both CYP24A1 and ZNF217 were found to have increased in the collected CRC samples as compared to the matched adjacent normal tissues. ZNF217, but not CYP24A1, showed a positive correlation between copy number increases and mRNA overexpression. These findings suggest the potential role of CNVs of certain oncogenes in CRCs.

语种英语
WOS记录号WOS:000284800500028
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63633
专题北京大学深圳医院
北京大学第二临床医学院_产科
作者单位1.Peking Univ, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China
2.Peking Univ, Biomed Res Inst, Shenzhen PKU HKUST Med Ctr, Shenzhen, Guangdong, Peoples R China
3.Ji Nan Univ, JNU HKUST Joint Lab, Jinan, Guangdong, Peoples R China
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GB/T 7714
Fang, Zhengyu,Xiong, Yi,Zhang, Chao,et al. Coexistence of copy number increases of ZNF217 and CYP24A1 in colorectal cancers in a Chinese population[J]. ONCOLOGY LETTERS,2010,1(5):925-930.
APA Fang, Zhengyu.,Xiong, Yi.,Zhang, Chao.,Li, Jiana.,Liu, Li.,...&Wan, Jun.(2010).Coexistence of copy number increases of ZNF217 and CYP24A1 in colorectal cancers in a Chinese population.ONCOLOGY LETTERS,1(5),925-930.
MLA Fang, Zhengyu,et al."Coexistence of copy number increases of ZNF217 and CYP24A1 in colorectal cancers in a Chinese population".ONCOLOGY LETTERS 1.5(2010):925-930.
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