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学科主题: 临床医学
题名:
Coexistence of copy number increases of ZNF217 and CYP24A1 in colorectal cancers in a Chinese population
作者: Fang, Zhengyu1,2; Xiong, Yi1,2; Zhang, Chao1,2; Li, Jiana1,2; Liu, Li1,2; Li, Manhui1,2; Zhang, Wei3; Wan, Jun1,2
关键词: colorectal cancer ; zinc-finger protein 217 ; 25-hydroxy vitamin D3 24-hydroxylase ; copy number variation
刊名: ONCOLOGY LETTERS
发表日期: 2010-09-01
DOI: 10.3892/ol_00000163
卷: 1, 期:5, 页:925-930
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: COMPARATIVE GENOMIC HYBRIDIZATION ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; CANDIDATE ONCOGENE ZNF217 ; GENE-EXPRESSION ; PROSTATE-CANCER ; CHROMOSOME 20Q ; COLON-CANCER ; ASSOCIATION ; GAIN
英文摘要:

Evidence suggests that the amplification of chromosome 20q13 is common in colorectal cancers (CRCs). Certain candidate oncogenes located in this region are reported to be associated with tumorigenesis of the gastrointestinal tract. The functional impact of such regions should be extensively investigated in a large number of clinical samples. In this study, 145 CRC samples with matched adjacent normal tissues were collected from a Chinese population for copy number variation (CNV) analysis. Our results showed that both the copy numbers of 25-hydroxy vitamin D3 24-hydroxylase (CYP24A1) and zinc-finger protein 217 (ZNF217) were amplified in a relatively high percentage of CRC samples (51.1 and 60%, respectively). The mRNA expression levels of both CYP24A1 and ZNF217 were found to have increased in the collected CRC samples as compared to the matched adjacent normal tissues. ZNF217, but not CYP24A1, showed a positive correlation between copy number increases and mRNA overexpression. These findings suggest the potential role of CNVs of certain oncogenes in CRCs.

语种: 英语
WOS记录号: WOS:000284800500028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63633
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China
2.Peking Univ, Biomed Res Inst, Shenzhen PKU HKUST Med Ctr, Shenzhen, Guangdong, Peoples R China
3.Ji Nan Univ, JNU HKUST Joint Lab, Jinan, Guangdong, Peoples R China

Recommended Citation:
Fang, Zhengyu,Xiong, Yi,Zhang, Chao,et al. Coexistence of copy number increases of ZNF217 and CYP24A1 in colorectal cancers in a Chinese population[J]. ONCOLOGY LETTERS,2010,1(5):925-930.
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