北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Soluble CD40 ligand is associated with angiographic severity of coronary artery disease in patients with acute coronary syndrome
作者: Zhao Wei1,2,3; Zhang Fan1,2,3; Li Zijian1,2,3; Yu Haiyi1,2,3; Li Zongshi1,2,3; Gao Wei1,2,3
关键词: atherosclerosis ; coronary artery disease ; acute coronary syndrome ; soluble CD40 ligand ; coronary angiography
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-06-20
DOI: 10.3760/cma.j.issn.0366-6999.20133159
卷: 127, 期:12, 页:2218-2221
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: UP-REGULATION ; ACTIVATION ; BIOMARKERS ; PLATELETS ; SYSTEM ; EXTENT ; CD154 ; RISK
英文摘要:

Background Recently, studies have disclosed soluble CD40 ligand (sCD40L) during atherosclerosis development and plaque destabilization. The objective of the present study was to test the hypothesis that sCD40L levels are higher in acute coronary syndrome (ACS) patients with a greater extent of angiographic coronary involvement.

Methods This cross-sectional study examined ACS patients who underwent coronary angiography by measuring their sCD40L levels. In order to estimate the serum levels of sCD40L, 10 ml of peripheral venous blood was drawn within 24 hours of admission. sCD40L levels were measured using an enzyme-linked immunosorbent assay (ELISA, RapidBio, West Hills, CA, USA). Demographic data, presence of concomitant diseases, ACS characteristics, and angiographic findings were evaluated. A review of medical records and patient interviews were conducted to assess coronary risk factors. And the severity of coronary artery disease was evaluated using the Gensini score index.

Results Two hundred and eighty-nine patients were included in the study, of whom 186 were male, with an average age of 64.1 +/- 10.0 years. Median sCD40L levels were 1.7 ng/ml (0.3-7.3 ng/ml) and Gensini scores were 50 (0-228). After adjusting for demographic variables and cardiovascular risk factors, the Gensini score was associated with the natural logarithm of the sCD40L level (Coefficient b=0.002, 95% Cl 0.000-0.003, P=0.029).

Conclusion sCD40L levels were independently associated with angiographic severity of coronary artery disease in patients with ACS.

语种: 英语
WOS记录号: WOS:000339220700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63636
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China

Recommended Citation:
Zhao Wei,Zhang Fan,Li Zijian,et al. Soluble CD40 ligand is associated with angiographic severity of coronary artery disease in patients with acute coronary syndrome[J]. CHINESE MEDICAL JOURNAL,2014,127(12):2218-2221.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhao Wei]'s Articles
[Zhang Fan]'s Articles
[Li Zijian]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhao Wei]‘s Articles
[Zhang Fan]‘s Articles
[Li Zijian]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace