IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
First multicenter study on multidrug resistant bacteria carriage in Chinese ICUs
Ma, Xiaojun1; Wu, Yinghong2; Li, Liuyi3; Xu, Qian4; Hu, Bijie5; Ni, Yuxing6; Wu, Anhua7; Sun, Shumei8; Jarlier, Vincent9,10; Robert, Jerome9,10
刊名BMC INFECTIOUS DISEASES
2015-08-21
DOI10.1186/s12879-015-1105-7
15
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
资助者bioMerieux, France ; bioMerieux, France
研究领域[WOS]Infectious Diseases
关键词[WOS]INTENSIVE-CARE-UNIT ; SPECTRUM BETA-LACTAMASE ; STAPHYLOCOCCUS-AUREUS ; ACINETOBACTER-BAUMANNII ; COLONIZATION ; ADMISSION ; ENTEROBACTERIACEAE ; HOSPITALS ; SPREAD
英文摘要

Background: The importance of multidrug-resistant organisms (MDRO) in Chinese hospitals is not clearly delineated. Thus we sought to assess the prevalence of MDRO in Chinese intensive care units (ICUs).

Methods: Prospective study of inpatients admitted consecutively to eight ICUs in four Chinese cities in 2009-10. Admission and weekly screenings were performed by using selective media for methicillin resistant Staphylococcus aureus, extended-spectrum beta-lactamase-producing Enterobacteriaceae, Acinetobacter and Pseudomonas aeruginosa. For the two latters, resistance to ceftazidime defined MDRO. Backward logistic regression models were designed to assess factors independently associated with MDRO carriage on admission and MDRO acquisition within ICUs.

Results: 686 patients were included, and the MDRO prevalence rate on admission was 30.5 % (32.7 % for ESBL-positive Enterobacteriaceae, 3.2 % for MRSA). Antibiotic treatment prior to ICU admission was independently associated with carriage on admission (OR: 1.4) in multivariate analysis. A total of 104 patients acquired >= 1 MDRO in ICU (overall attack rate: 23.7 %; 14.9 % for ESBL-positive Enterobacteriaceae, and 5.1 % for MRSA). The MDRO attack rate increased from 13.2 % in the first week to 82.1 % for ICU stay > 3 weeks. Duration of antibiotic exposure (OR: 1.16; 1.1-1.2) and prior antibiotic treatment before ICU (OR: 2.1; 1.1-3.3) were associated with MDRO acquisition in multivariate analysis. The MDRO prevalence rate on ICU discharge was 51.2 % and the global prevalence density rate 71 per 1000 hospital-days.

Conclusion: More than one out of two patients was MDRO carrier on ICU discharge in Chinese hospitals. This is the result of the combination of a high MDRO prevalence rate on ICU admission and a high MDRO acquisition rate within ICU.

语种英语
资助者bioMerieux, France ; bioMerieux, France
WOS记录号WOS:000359764700002
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63639
专题北京大学第一临床医学院
作者单位1.Peking Univ Peoples Hosp, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
3.China Japan Friendship Hosp, Beijing, Peoples R China
4.Fudan Univ, Zhongshan Hosp, Shanghai 200433, Peoples R China
5.Cent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
6.Pitie Salpetriere Univ Hosp, AP HP, Paris, France
7.Beijing Union Med Coll Hosp, Beijing, Peoples R China
8.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai 200030, Peoples R China
9.South Med Univ, Nanfang Hosp, Guangdong, Peoples R China
10.Univ Paris 06, Univ Paris 04, Team Bacteriol E13, CR7,INSERM,U1135,CIMI, F-75013 Paris, France
推荐引用方式
GB/T 7714
Ma, Xiaojun,Wu, Yinghong,Li, Liuyi,et al. First multicenter study on multidrug resistant bacteria carriage in Chinese ICUs[J]. BMC INFECTIOUS DISEASES,2015,15.
APA Ma, Xiaojun.,Wu, Yinghong.,Li, Liuyi.,Xu, Qian.,Hu, Bijie.,...&Robert, Jerome.(2015).First multicenter study on multidrug resistant bacteria carriage in Chinese ICUs.BMC INFECTIOUS DISEASES,15.
MLA Ma, Xiaojun,et al."First multicenter study on multidrug resistant bacteria carriage in Chinese ICUs".BMC INFECTIOUS DISEASES 15(2015).
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