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Effect of the chloro-substitution on lowering diabetic hyperglycemia of vanadium complexes with their permeability and cytotoxicity
Xie, Ming-Jin1; Niu, Yan-Fen2; Yang, Xiao-Da3; Liu, Wei-Ping4; Li, Ling2; Gao, Li-Hui2; Yan, Shi-Ping5; Meng, Zhao-Hui6
关键词Salen-type ligands Substituent effect Anti-diabetic activity
刊名EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2010-12-01
DOI10.1016/j.ejmech.2010.10.013
45期:12页:6077-6084
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]CAMBRIDGE STRUCTURAL DATABASE ; SCHIFF-BASE LIGANDS ; CRYSTAL-STRUCTURE ; IN-VIVO ; DIOXOVANADIUM(V) COMPLEXES ; MOLECULAR-STRUCTURE ; BLOOD-GLUCOSE ; INSULIN ; RATS ; CHEMISTRY
英文摘要

The effect of the chloro-substitution of dinuclear vanadium (V) complexes on lowering diabetic hyperglycemia was evaluated. The in vivo tests for hypoglycemic activity show that complex 2 at the dose of 10.0 and 20.0 mg V kg(-1), could significantly decrease the blood glucose level. Importantly, our results the chloro substituent increased the insulin-enhancing properties of the complex 2. The two vanadium compounds had permeability above 10(-5) cm/s. It suggested that two complexes permeate via a passive diffusion mechanism. It was also suggested that two complexes has better good lipophilic properties. The cytotoxicity of two complexes on Caco-2 cells suggested the chlorine atom at C4 of complex 2 increased cytotoxicity for vanadium complexes. (C) 2010 Elsevier Masson SAS. All rights reserved.

语种英语
WOS记录号WOS:000285485000063
项目编号30260118 ; 2002C0019R ; 2005 Q002A ; 2009CD006
资助机构National Natural Science Foundation of China ; Yunnan Natural Science Foundation ; Yunnan University Science Foundation
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63650
专题北京大学药学院_化学生物学系
作者单位1.Yunnan Univ, Dept Chem, Kunming 650091, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming 650031, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
4.Kunming Inst Precious Met, Kunming 650221, Peoples R China
5.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
6.Kunming Populat & Hlth Hosp, Kunming 650018, Peoples R China
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Xie, Ming-Jin,Niu, Yan-Fen,Yang, Xiao-Da,et al. Effect of the chloro-substitution on lowering diabetic hyperglycemia of vanadium complexes with their permeability and cytotoxicity[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2010,45(12):6077-6084.
APA Xie, Ming-Jin.,Niu, Yan-Fen.,Yang, Xiao-Da.,Liu, Wei-Ping.,Li, Ling.,...&Meng, Zhao-Hui.(2010).Effect of the chloro-substitution on lowering diabetic hyperglycemia of vanadium complexes with their permeability and cytotoxicity.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,45(12),6077-6084.
MLA Xie, Ming-Jin,et al."Effect of the chloro-substitution on lowering diabetic hyperglycemia of vanadium complexes with their permeability and cytotoxicity".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 45.12(2010):6077-6084.
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