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学科主题: 临床医学
题名:
IL-1B rs1143623 and EEF1A1P11-RPL7P9 rs10783050 polymorphisms affect the glucose-lowing efficacy of metformin in Chinese overweight or obese Type 2 diabetes mellitus patients
作者: Xiao, Di1,2,3; Zhang, Si-Min4; Li, Xi1,2,3; Yin, Ji-Ye1,2,3; Gong, Wei-Jing1,2; Zheng, Yi5; Xu, Xiao-Jing1,2; Lin, Xu6; Ji, Li-Nong4; Liu, Rang-Ru1,2; Tang, Qiang7; Zhang, Wei1,2,3; Zhou, Hong-Hao1,2,3; Han, Xue-Yao4; Liu, Zhao-Qian1,2,3
关键词: glucose-lowing efficacy ; metformin ; obese ; overweight ; pharmacogenomics ; SNP ; Type 2 diabetes mellitus
刊名: PHARMACOGENOMICS
发表日期: 2015
DOI: 10.2217/pgs.15.95
卷: 16, 期:14, 页:1621-1629
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PREVENTION PROGRAM ; RISK ; ACTIVATION ; OCT1 ; INTERLEUKIN-6 ; INFLAMMATION ; ASSOCIATION ; POPULATION ; PREVALENCE ; VARIANTS
英文摘要:

Aim: To investigate the potential genetic effect on metformin efficacy in overweight or obese Chinese Type 2 diabetes mellitus (T2DM) patients. Patients & methods: 768 SNPs in or close to 207 genes were genotyped in 84 patients treated with metformin + glibenclamide/Xiaoke Pill. Significant SNPs were then verified in 107 recent-onset overweight or obese T2DM patients treated with metformin alone. Genotyping was done by Illumina GoldenGate Assay. Results: In the discovery stage, 22 SNPs were nominally significant. IL1B rs1143623 (p = 0.011) and EEF1A1P11-RPL7P9 rs10783050 (p = 0.021) were still significantly associated with the relative change of HbA(1c) in the replication stage. Conclusion:IL1B rs1143623 and EEF1A1P11-RPL7P9 rs10783050 polymorphisms may contribute to metformin′s glucose-lowing efficacy in overweight or obese Chinese T2DM patients.

语种: 英语
所属项目编号: 2009AA022704 ; 2012AA02A517 ; 2012AA02A518 ; 81173129 ; 81202595 ; 81373490 ; 81273595
项目资助者: National High-tech R&amp ; D Program of China (863 Program) ; National Natural Science Foundation of China
WOS记录号: WOS:000363397900008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63652
Appears in Collections:北京大学第二临床医学院_内分泌科_期刊论文

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作者单位: 1.Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China
2.Huaihua Third Peoples Hosp, Dept Pharm, Huaihua 418000, Peoples R China
3.Cent S Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410008, Hunan, Peoples R China
4.Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China
5.Peoples Hosp Peking Univ, Dept Endocrinol, Beijing 100044, Peoples R China
6.Maternal & Child Hlth Hosp Hunan Prov, Changsha 410008, Hunan, Peoples R China
7.Chinese Acad Sci, Shanghai Sch Biol Sci, Inst Nutr Sci, Shanghai 20031, Peoples R China

Recommended Citation:
Xiao, Di,Zhang, Si-Min,Li, Xi,et al. IL-1B rs1143623 and EEF1A1P11-RPL7P9 rs10783050 polymorphisms affect the glucose-lowing efficacy of metformin in Chinese overweight or obese Type 2 diabetes mellitus patients[J]. PHARMACOGENOMICS,2015,16(14):1621-1629.
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