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IR@PKUHSC  > 北京大学临床肿瘤学院  > 超声科  > 期刊论文
学科主题: 临床医学
题名:
Clinical Value of Real Time Elastography in Patients with Unexplained Cervical Lymphadenopathy: Quantitative Evaluation
作者: Fu, Ying1; Shi, Yun-Fei2; Yan, Kun1; Wang, Yan-Jie1; Yang, Wei1; Feng, Guo-Shuang3
关键词: Ultrasonography ; elastography ; cervical ; differential diagnosis ; lymphadenopathy
刊名: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
发表日期: 2014
DOI: 10.7314/APJCP.2014.15.13.5487
卷: 15, 期:13, 页:5487-5492
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ULTRASOUND ELASTOGRAPHY ; LYMPH-NODES ; SONOGRAPHY ; DIFFERENTIATION ; METASTASIS ; DIAGNOSIS ; CANCER ; BENIGN ; US
英文摘要:

Ultrasonography is non-invasive and can give useful clues in the diagnosis of cervical lymphadenopathy, However, differential diagnosis is difficult in some situations even combined with color Doppler imaging. The present study was conducted to evaluate the clinical value of real time elastography in patients with unexplained cervical lymphadenopathy using a quantitative method. From May 2011 to February 2012, 39 enlarged lymph nodes from 39 patients with unexplained cervical lymphadenopathy were assessed. All the patients were examined by both B-mode ultrasound, color Doppler flow imaging and elastography. The method of analyzing elasto-graphic data was the calculation of the 10 parametres ("mean", "sd", "area %", "com", "kur", "ske", "con", "ent", "idm", "asm") offered by the software integrated into the Hitachi system. The findings were then correlated with the definitive tissue diagnosis obtained by lymph node dissection or biopsy. Final histology revealed 10 cases of metastatic lymph nodes, 11 cases of lymphoma, 12 cases of tuberculosis and 6 cases of nonspecific lymphadenitis. The significant distinguishing features for conventional ultrasound were the maximum short diameter (p=0.007) and absent of echogenic hilum (p=0.0293). The diagnostic accuracy was 43.6% (17/39 cases) and there were 17 patients with equivocal diagnosis. For elastography, "mean" (p=0.003), "area %" (p=0.009), "kurt" (p=0.0291), "skew" (p=0.014) and "cont" (p=0.012) demonstrated significant differences between groups. With 9 of the 17 patients with previous equivocal diagnoses (52.9%) definite and correct diagnoses could be obtained. The diagnostic accuracy for conventional ultrasound combined elastography was 69.2% (27/39 cases). There were differences in the diagnostic sensitivity of the two methods (p=0.0224). Ultrasound combined with elastography demonstrated higher rates of conclusive and accurate diagnoses in patients with unexplained cervical lymphadenopathy than conventional ultrasound. The quantitative program showed good correlation with the pathology of different lymph node diseases.

语种: 英语
所属项目编号: 2011-2015-01 ; 2013-3-086
项目资助者: Capital Medical Development Program ; Beijing Municipal Health System Special funds of High-Level Medical Personnel Construction
WOS记录号: WOS:000343722900066
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63653
Appears in Collections:北京大学临床肿瘤学院_超声科_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Ultrasound, Beijing 100871, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
3.Chinese Ctr Dis Control & Prevent, Natl Ctr Publ Hlth Surveillance & Informat Serv, Beijing, Peoples R China

Recommended Citation:
Fu, Ying,Shi, Yun-Fei,Yan, Kun,et al. Clinical Value of Real Time Elastography in Patients with Unexplained Cervical Lymphadenopathy: Quantitative Evaluation[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(13):5487-5492.
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