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学科主题: 临床医学
题名:
Carcinoma of the ampulla of vater: Factors influencing long-term survival of 127 patients with resection
作者: Qiao, Qi-lu; Zhao, Yi-guo; Ye, Mu-lin,; Yang, Yin-mo; Zhao, Jian-xun; Huang, Yan-ting; Wan, Yuan-lian
刊名: WORLD JOURNAL OF SURGERY
发表日期: 2007
DOI: 10.1007/s00268-006-0213-3
卷: 31, 期:1, 页:137-146
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: RADICAL RESECTION ; LOCAL RESECTION ; PERIAMPULLARY ADENOCARCINOMA ; PROGNOSTIC FACTORS ; SURGICAL-TREATMENT ; PANCREATICODUODENECTOMY ; CANCER ; TUMORS ; MORTALITY ; PAPILLA
英文摘要:

Introduction: The prognosis for patients with carcinoma of the ampulla of Vater is improved relative to other periampullary neoplasms. Identification of independent prognostic factors in ampullary carcinomas has been limited by the small number of tumors resected. The aim of the present study was to determine the clinicopathologic factors that influence long-term survival in patients with resected ampullary carcinoma.

Methods: Clinicopathologic data were retrospectively reviewed for patients with ampullary carcinomas radically resected between March 1987 and September 2002. The correlation between clinicopathologic variables and survival of patients after resection was examined by the Kaplan-Meier method, the log-rank test, and Cox proportional hazards regression. Ampullary carcinomas were radically resected in 127 patients either by pancreaticoduodenectomy (n = 124) or local resection (n = 3).

Results: Hospital mortality was 9.7%. The overall actuarial survival rates (including hospital deaths) at 1, 3, 5, and 10 years were 76.2%, 46.8%, 43.3%, and 35.7%, respectively. Factors that significantly influenced survival were lymph node status (P < 0.001), depth of tumor infiltration (P = 0.029), and TNM stage (P < 0.001) on univariate analysis. On multivariate analysis, both depth of infiltration and lymph node status were the independent determinants of survival after resection (P = 0.003, P = 0.005, respectively).

Conclusions: Carcinoma of the ampulla of Vater has a higher resectability rate and a much better survival rate than pancreatic cancer. Pancreaticoduodenectomy is the treatment of choice for this tumor. Long-term survival was independently influenced by the depth of tumor infiltration and lymph node metastasis.

语种: 英语
WOS记录号: WOS:000243365100023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63657
Appears in Collections:北京大学第一临床医学院_普通外科_期刊论文

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作者单位: Peking Univ, Dept Surg, First Hosp, Beijing 100034, Peoples R China

Recommended Citation:
Qiao, Qi-lu,Zhao, Yi-guo,Ye, Mu-lin,,et al. Carcinoma of the ampulla of vater: Factors influencing long-term survival of 127 patients with resection[J]. WORLD JOURNAL OF SURGERY,2007,31(1):137-146.
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