IR@PKUHSC  > 北京大学第一临床医学院  > 普通外科
学科主题临床医学
Carcinoma of the ampulla of vater: Factors influencing long-term survival of 127 patients with resection
Qiao, Qi-lu; Zhao, Yi-guo; Ye, Mu-lin,; Yang, Yin-mo; Zhao, Jian-xun; Huang, Yan-ting; Wan, Yuan-lian
刊名WORLD JOURNAL OF SURGERY
2007
DOI10.1007/s00268-006-0213-3
31期:1页:137-146
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery
研究领域[WOS]Surgery
关键词[WOS]RADICAL RESECTION ; LOCAL RESECTION ; PERIAMPULLARY ADENOCARCINOMA ; PROGNOSTIC FACTORS ; SURGICAL-TREATMENT ; PANCREATICODUODENECTOMY ; CANCER ; TUMORS ; MORTALITY ; PAPILLA
英文摘要

Introduction: The prognosis for patients with carcinoma of the ampulla of Vater is improved relative to other periampullary neoplasms. Identification of independent prognostic factors in ampullary carcinomas has been limited by the small number of tumors resected. The aim of the present study was to determine the clinicopathologic factors that influence long-term survival in patients with resected ampullary carcinoma.

Methods: Clinicopathologic data were retrospectively reviewed for patients with ampullary carcinomas radically resected between March 1987 and September 2002. The correlation between clinicopathologic variables and survival of patients after resection was examined by the Kaplan-Meier method, the log-rank test, and Cox proportional hazards regression. Ampullary carcinomas were radically resected in 127 patients either by pancreaticoduodenectomy (n = 124) or local resection (n = 3).

Results: Hospital mortality was 9.7%. The overall actuarial survival rates (including hospital deaths) at 1, 3, 5, and 10 years were 76.2%, 46.8%, 43.3%, and 35.7%, respectively. Factors that significantly influenced survival were lymph node status (P < 0.001), depth of tumor infiltration (P = 0.029), and TNM stage (P < 0.001) on univariate analysis. On multivariate analysis, both depth of infiltration and lymph node status were the independent determinants of survival after resection (P = 0.003, P = 0.005, respectively).

Conclusions: Carcinoma of the ampulla of Vater has a higher resectability rate and a much better survival rate than pancreatic cancer. Pancreaticoduodenectomy is the treatment of choice for this tumor. Long-term survival was independently influenced by the depth of tumor infiltration and lymph node metastasis.

语种英语
WOS记录号WOS:000243365100023
引用统计
被引频次:87[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63657
专题北京大学第一临床医学院_普通外科
作者单位Peking Univ, Dept Surg, First Hosp, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Qiao, Qi-lu,Zhao, Yi-guo,Ye, Mu-lin,,et al. Carcinoma of the ampulla of vater: Factors influencing long-term survival of 127 patients with resection[J]. WORLD JOURNAL OF SURGERY,2007,31(1):137-146.
APA Qiao, Qi-lu.,Zhao, Yi-guo.,Ye, Mu-lin,.,Yang, Yin-mo.,Zhao, Jian-xun.,...&Wan, Yuan-lian.(2007).Carcinoma of the ampulla of vater: Factors influencing long-term survival of 127 patients with resection.WORLD JOURNAL OF SURGERY,31(1),137-146.
MLA Qiao, Qi-lu,et al."Carcinoma of the ampulla of vater: Factors influencing long-term survival of 127 patients with resection".WORLD JOURNAL OF SURGERY 31.1(2007):137-146.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Qiao, Qi-lu]的文章
[Zhao, Yi-guo]的文章
[Ye, Mu-lin,]的文章
百度学术
百度学术中相似的文章
[Qiao, Qi-lu]的文章
[Zhao, Yi-guo]的文章
[Ye, Mu-lin,]的文章
必应学术
必应学术中相似的文章
[Qiao, Qi-lu]的文章
[Zhao, Yi-guo]的文章
[Ye, Mu-lin,]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。