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学科主题: 临床医学
题名:
Clinicopathological significance of altered metallothionein 2A expression in gastric cancer according to Lauren′s classification
作者: Pan Yuan-ming1; Xing Rui2; Cui Jian-tao2; Li Wen-mei2; Lu You-yong2
关键词: metallothionein 2A ; gastric cancer ; prognosis ; Lauren&prime ; s classification
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2013-07-20
DOI: 10.3760/cma.j.issn.0366-6999.20130579
卷: 126, 期:14, 页:2681-2686
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; COLORECTAL-CANCER ; GENE-EXPRESSION ; BREAST-CANCER ; PROMOTES ; THERAPY ; MIR-23A ; PROTEIN ; ALPHA
英文摘要:

Background Dysregulated nnetallothionein 2A (MT2A) has been implicated in carcinogenesis. The purpose of this study was to investigate the expression of MT2A in gastric cancer (GC) and its correlation with prognosis.

Methods Reverse transcription-polymerase chain reaction and real-time polymerase chain reaction were used to detect the mRNA expression of MT2A in 12 GC cell lines, normal gastric epithelial GES-1 cells, and 36 GC and adjacent normal tissues. MT2A protein expression was determined in 258 GC tissues and 171 adjacent normal tissues by immunohistochemistry.

Results MT2A mRNA expression was lower in GC cells and primary tumors than in GES-1 cells and adjacent normal tissues, respectively. High protein expression of MT2A was present in 130 of 171 normal tissues (76.0%) and in 56 of 258 GC tissues (21.7%; P <0.001). MT2A protein expression was higher in well/moderately differentiated GC (22/54; 40.7%) than in poorly differentiated GC (34/204; 16.7%; P <0.001). Moreover, the protein expression of MT2A was lower in diffuse-type GC (6/82; 7.3%) than in intestinal-type GC (50/176; 28.4%; P=0.0001). Importantly, MT2A expression was an independent prognostic factor for GC, and decreased MT2A expression was associated with poor clinical outcome (P <0.001). The expression status of MT2A could predict prognosis in intestinal and diffuse-type GCs.

Conclusion Expression status of MT2A might be a useful prognostic biomarker for GC, especially when used in combination with Lauren′s classification.

语种: 英语
所属项目编号: 2012AA02A504
项目资助者: National Bio-Tech 863 Program
WOS记录号: WOS:000329015300018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63659
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R China
2.Peking Univ, Key Lab Carcinogenesis & Translat Res, Beijing Canc Hosp Inst, Lab Mol Oncol,Minist Educ,Sch Oncol, Beijing 100142, Peoples R China

Recommended Citation:
Pan Yuan-ming,Xing Rui,Cui Jian-tao,et al. Clinicopathological significance of altered metallothionein 2A expression in gastric cancer according to Lauren&prime;s classification[J]. CHINESE MEDICAL JOURNAL,2013,126(14):2681-2686.
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