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学科主题: 临床医学
题名:
Weight-neutral effect of once-daily insulin detemir in Chinese type 2 diabetes patients: Subgroup analysis of the SOLVE study
作者: Pan, Changyu1; Han, Ping4; Ji, Linong2; Ji, Qiuhe5; Lu, Juming1; Lin, Jing3; Liu, Jie6; Su, Benli7; Shi, Jingmei8; Wang, Penghua9
关键词: body mass index ; body weight ; insulin detemir ; type 2 diabetes mellitus
刊名: JOURNAL OF DIABETES
发表日期: 2015-03-01
DOI: 10.1111/1753-0407.12179
卷: 7, 期:2, 页:222-230
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: IMPROVES GLYCEMIC CONTROL ; NPH INSULIN ; NAIVE PATIENTS ; BODY-WEIGHT ; FOOD-INTAKE ; THERAPY ; GAIN ; MELLITUS ; OVERWEIGHT ; GLARGINE
英文摘要:

BackgroundThe present subanalysis of the Study of Once Daily Levemir (SOLVE) study was to evaluate the safety and efficacy of once-daily insulin detemir as add-on to oral antidiabetic drugs (OADs) in Chinese type 2 diabetes patients according to body mass index in a real-life setting.

MethodsIn all, 3272 eligible patients who were treated with diet, exercise, and one or more OAD were prescribed once-daily insulin detemir by their physician according to routine clinical practice and were followed-up for 24 weeks. The incidence of serious adverse reactions (SADRs), including major hypoglycemia, was the primary endpoint. Subanalyses were performed on patients in the following BMI groups: normal weight (BMI<25kg/m(2)); overweight (25BMI<30kg/m(2)); and obese (BMI30kg/m(2)).

ResultsNo SADRs were reported during the study. Significant improvements in glycemic levels were observed in all subgroups. For normal weight, overweight, and obese patients, the mean change in HbA1c (%/[mmol/mol]) was -1.26/-14, -1.09/-12, and -1.06/-12, respectively. The mean change in fasting plasma glucose in normal weight, overweight, and obese patients was -2.77, -2.57, and -2.71mmol/L, respectively. Slight weight gain (0.25kg), slight weight loss (-0.36kg), and weight loss (-1.32kg) were observed in the normal weight, overweight, and obese patients, respectively (P<0.001). Linear regression analysis revealed a negative relationship between weight change and baseline BMI (slope=-0.16; P<0.001).

ConclusionsOnce-daily insulin detemir as add-on to OADs in Chinese patients with type 2 diabetes showed effective glycemic control and a low risk of hypoglycemia. Weight-neutral effects were observed in different BMI subgroups.

语种: 英语
项目资助者: Novo Nordisk
WOS记录号: WOS:000349127200013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63660
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
2.Beijing Huaxin Hosp, Beijing, Peoples R China
3.4th Mil Med Univ, Xijing Hosp, Xian, Peoples R China
4.Shanxi Prov Peoples Hosp, Taiyuan, Peoples R China
5.Dalian Med Univ, Affiliated Hosp 2, Dalian, Peoples R China
6.Yuncheng Tongde Hosp, Yuncheng, Peoples R China
7.Tianjin Med Univ, Metab Dis Hosp, Tianjin, Peoples R China
8.Chinese Peoples Liberat Army Gen Hosp, Beijing 100853, Peoples R China
9.China Med Univ, Shengjing Hosp, Shenyang 110001, Peoples R China

Recommended Citation:
Pan, Changyu,Han, Ping,Ji, Linong,et al. Weight-neutral effect of once-daily insulin detemir in Chinese type 2 diabetes patients: Subgroup analysis of the SOLVE study[J]. JOURNAL OF DIABETES,2015,7(2):222-230.
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