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学科主题: 公共卫生
题名:
A novel carrier of radionuclide based on surface modified poly(lactide-co-glycolide) nanofibrous membrane
作者: Nie, Huarong2; He, Aihua1; Jia, Bing3; Wang, Fan3; Jiang, Qingsong2; Han, Charles C.4
关键词: Poly(lactide-co-glycolide) nanofibrous membranes ; Radionuclide ; Surface modification
刊名: POLYMER
发表日期: 2010-07-08
DOI: 10.1016/j.polymer.2010.05.014
卷: 51, 期:15, 页:3344-3348
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Polymer Science
研究领域[WOS]: Polymer Science
关键词[WOS]: IN-VITRO ; MICROSPHERES ; SCAFFOLDS ; LIPOSOMES ; DELIVERY ; GELATIN ; THERAPY ; CANCER
英文摘要:

Electrospun nanofibrous membrane is an approved drug carrier. However, the radionuclide carrier used an electrospun membrane is rare. In this study. Poly(lactide-co-glycolide)(PLGA) nanofibrous nonwovens were prepared through electrospinning technology, and then surface modification of the nonwoven was performed to stably conjugate the radioisotope with the fibrous membrane. A novel PLGA nanofibrous nonwoven conjugated with radioactive yttrium (90)Y for tumor internal radiotherapy was prepared for the first time. Evaluation of the stability of the radioisotope indicated that the leakage of (90)Y from the PLGA membranes can be neglected after 24 h incubation in saline. The retention of (90)Y on the PLGA membrane was 75% when five half lives of (90)Y expired and the vast majority of radioactive decay had occurred. This labeled nanofibrous membrane function as a novel radio-medical appliance with excellent surface hydrophilic and mechanical properties that can be directly implanted into the lesions not only to locally kill the cancerous cells but also to play the anti-adhesion role at where surgical procedures have been made to remove the tumor tissue. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 50973123 ; 50503023 ; 50821062 ; CMS-Y200709 ; 2009GQC0086
项目资助者: National Nature Science Foundation of China ; CAS ; Natural Science Foundation of Jiangxi Province
WOS记录号: WOS:000279756000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63661
Appears in Collections:北京大学医药卫生分析中心_期刊论文

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作者单位: 1.Qingdao Univ Sci & Technol, Sch Polymer Sci & Engn, Key Lab Rubber Plast, Minist Educ, Qingdao 266042, Peoples R China
2.Nanchang Univ, Sch Mat Sci & Engn, Nanchang 330047, Peoples R China
3.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Joint Lab Polymer Sci & Mat, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem,Inst Chem, Beijing 100190, Peoples R China

Recommended Citation:
Nie, Huarong,He, Aihua,Jia, Bing,et al. A novel carrier of radionuclide based on surface modified poly(lactide-co-glycolide) nanofibrous membrane[J]. POLYMER,2010,51(15):3344-3348.
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