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A novel carrier of radionuclide based on surface modified poly(lactide-co-glycolide) nanofibrous membrane
Nie, Huarong2; He, Aihua1; Jia, Bing3; Wang, Fan3; Jiang, Qingsong2; Han, Charles C.4
关键词Poly(lactide-co-glycolide) nanofibrous membranes Radionuclide Surface modification
刊名POLYMER
2010-07-08
DOI10.1016/j.polymer.2010.05.014
51期:15页:3344-3348
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Polymer Science
研究领域[WOS]Polymer Science
关键词[WOS]IN-VITRO ; MICROSPHERES ; SCAFFOLDS ; LIPOSOMES ; DELIVERY ; GELATIN ; THERAPY ; CANCER
英文摘要

Electrospun nanofibrous membrane is an approved drug carrier. However, the radionuclide carrier used an electrospun membrane is rare. In this study. Poly(lactide-co-glycolide)(PLGA) nanofibrous nonwovens were prepared through electrospinning technology, and then surface modification of the nonwoven was performed to stably conjugate the radioisotope with the fibrous membrane. A novel PLGA nanofibrous nonwoven conjugated with radioactive yttrium (90)Y for tumor internal radiotherapy was prepared for the first time. Evaluation of the stability of the radioisotope indicated that the leakage of (90)Y from the PLGA membranes can be neglected after 24 h incubation in saline. The retention of (90)Y on the PLGA membrane was 75% when five half lives of (90)Y expired and the vast majority of radioactive decay had occurred. This labeled nanofibrous membrane function as a novel radio-medical appliance with excellent surface hydrophilic and mechanical properties that can be directly implanted into the lesions not only to locally kill the cancerous cells but also to play the anti-adhesion role at where surgical procedures have been made to remove the tumor tissue. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000279756000002
项目编号50973123 ; 50503023 ; 50821062 ; CMS-Y200709 ; 2009GQC0086
资助机构National Nature Science Foundation of China ; CAS ; Natural Science Foundation of Jiangxi Province
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63661
专题北京大学医药卫生分析中心
北京大学基础医学院
作者单位1.Qingdao Univ Sci & Technol, Sch Polymer Sci & Engn, Key Lab Rubber Plast, Minist Educ, Qingdao 266042, Peoples R China
2.Nanchang Univ, Sch Mat Sci & Engn, Nanchang 330047, Peoples R China
3.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Joint Lab Polymer Sci & Mat, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem,Inst Chem, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Nie, Huarong,He, Aihua,Jia, Bing,et al. A novel carrier of radionuclide based on surface modified poly(lactide-co-glycolide) nanofibrous membrane[J]. POLYMER,2010,51(15):3344-3348.
APA Nie, Huarong,He, Aihua,Jia, Bing,Wang, Fan,Jiang, Qingsong,&Han, Charles C..(2010).A novel carrier of radionuclide based on surface modified poly(lactide-co-glycolide) nanofibrous membrane.POLYMER,51(15),3344-3348.
MLA Nie, Huarong,et al."A novel carrier of radionuclide based on surface modified poly(lactide-co-glycolide) nanofibrous membrane".POLYMER 51.15(2010):3344-3348.
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