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学科主题: 公共卫生
题名:
Serum Inflammatory Factors in Patients with Idiopathic Choroidal Neovascularization
作者: Yang, Fan2; Dou, Hong-Liang2; Ma, Zhizhong2; Li, Yu-Ling2; Lu, Xin-Rong2; Wang, Xin2; He, Ping-Ping1
关键词: complement ; CRP ; idiopathic CNV ; IL1-beta ; immunoglobulin ; TNF alpha ; VEGF
刊名: OCULAR IMMUNOLOGY AND INFLAMMATION
发表日期: 2010-10-01
DOI: 10.3109/09273948.2010.483315
卷: 18, 期:5, 页:390-394
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; RETINAL-PIGMENT EPITHELIUM ; COMPLEMENT FACTOR-H ; C-REACTIVE PROTEIN ; MACULAR DEGENERATION ; YOUNG-PATIENTS ; TNF-ALPHA ; AGE ; SUBFOVEAL ; POLYMORPHISM
英文摘要:

Objective: To investigate serum inflammatory factors in patients with idiopathic choroidal vascularization (CNV), including vascular endothelial growth factor (VEGF), tumor necrosis factor alpha (TNF alpha), Interleukin1-beta (IL1-beta), IgG, IgA, IgM, IgE, 50% hemolytic unit of complement (CH50), complement C3, complement C4 and C reactive protein (CRP).

Methods: 21 patients and 20 normal individuals were recruited. They received comprehensive ophthalmic examinations. Serous concentrations of VEGF, TNFa, IL1-beta were assayed by ELISA, and the concentrations of other serum factor were assayed by immunonephelometry.

Results: The mean serum VEGF level in the CNV group was significantly greater than that in the control group (p=0.025). The median level of IgE in the CNV group was significantly lower than that in the control group (p=0.006). Statistical analysis revealed no significant difference in the levels of INF alpha, IL1-beta, IgG, IgA, IgM, CH50, C3, C4 or CRP between the two groups.

Conclusion: The possible roles of these factors and mechanisms of idiopathic CNV formation were analyzed. Serum VEGF and IgE levels may play an important role in the formation of idiopathic CNV.

语种: 英语
WOS记录号: WOS:000283482600013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63672
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Ctr Hlth, Inst Publ Hlth, Beijing, Peoples R China
2.Peking Univ, Ctr Eye, Hosp 3, Beijing, Peoples R China

Recommended Citation:
Yang, Fan,Dou, Hong-Liang,Ma, Zhizhong,et al. Serum Inflammatory Factors in Patients with Idiopathic Choroidal Neovascularization[J]. OCULAR IMMUNOLOGY AND INFLAMMATION,2010,18(5):390-394.
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