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Serum Inflammatory Factors in Patients with Idiopathic Choroidal Neovascularization
Yang, Fan2; Dou, Hong-Liang2; Ma, Zhizhong2; Li, Yu-Ling2; Lu, Xin-Rong2; Wang, Xin2; He, Ping-Ping1
关键词complement CRP idiopathic CNV IL1-beta immunoglobulin TNF alpha VEGF
刊名OCULAR IMMUNOLOGY AND INFLAMMATION
2010-10-01
DOI10.3109/09273948.2010.483315
18期:5页:390-394
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; RETINAL-PIGMENT EPITHELIUM ; COMPLEMENT FACTOR-H ; C-REACTIVE PROTEIN ; MACULAR DEGENERATION ; YOUNG-PATIENTS ; TNF-ALPHA ; AGE ; SUBFOVEAL ; POLYMORPHISM
英文摘要

Objective: To investigate serum inflammatory factors in patients with idiopathic choroidal vascularization (CNV), including vascular endothelial growth factor (VEGF), tumor necrosis factor alpha (TNF alpha), Interleukin1-beta (IL1-beta), IgG, IgA, IgM, IgE, 50% hemolytic unit of complement (CH50), complement C3, complement C4 and C reactive protein (CRP).

Methods: 21 patients and 20 normal individuals were recruited. They received comprehensive ophthalmic examinations. Serous concentrations of VEGF, TNFa, IL1-beta were assayed by ELISA, and the concentrations of other serum factor were assayed by immunonephelometry.

Results: The mean serum VEGF level in the CNV group was significantly greater than that in the control group (p=0.025). The median level of IgE in the CNV group was significantly lower than that in the control group (p=0.006). Statistical analysis revealed no significant difference in the levels of INF alpha, IL1-beta, IgG, IgA, IgM, CH50, C3, C4 or CRP between the two groups.

Conclusion: The possible roles of these factors and mechanisms of idiopathic CNV formation were analyzed. Serum VEGF and IgE levels may play an important role in the formation of idiopathic CNV.

语种英语
WOS记录号WOS:000283482600013
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63672
专题北京大学公共卫生学院
北京大学基础医学院
北京大学公共卫生学院_公共卫生学院
北京大学第三临床医学院_眼科
作者单位1.Peking Univ, Ctr Hlth, Inst Publ Hlth, Beijing, Peoples R China
2.Peking Univ, Ctr Eye, Hosp 3, Beijing, Peoples R China
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GB/T 7714
Yang, Fan,Dou, Hong-Liang,Ma, Zhizhong,et al. Serum Inflammatory Factors in Patients with Idiopathic Choroidal Neovascularization[J]. OCULAR IMMUNOLOGY AND INFLAMMATION,2010,18(5):390-394.
APA Yang, Fan.,Dou, Hong-Liang.,Ma, Zhizhong.,Li, Yu-Ling.,Lu, Xin-Rong.,...&He, Ping-Ping.(2010).Serum Inflammatory Factors in Patients with Idiopathic Choroidal Neovascularization.OCULAR IMMUNOLOGY AND INFLAMMATION,18(5),390-394.
MLA Yang, Fan,et al."Serum Inflammatory Factors in Patients with Idiopathic Choroidal Neovascularization".OCULAR IMMUNOLOGY AND INFLAMMATION 18.5(2010):390-394.
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