|Clinical Study of Sclerotherapy of Maxillofacial Venous Malformation Using Absolute Ethanol and Pingyangmycin|
|Liu, Yu1; Liu, Denggao2; Wang, Yixiang1; Zhang, Wei1; Zhao, Fuyun1|
|刊名||JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY|
|WOS标题词||Science & Technology|
|类目[WOS]||Dentistry, Oral Surgery & Medicine|
|研究领域[WOS]||Dentistry, Oral Surgery & Medicine|
|关键词[WOS]||VASCULAR MALFORMATIONS ; HEMANGIOMAS ; NECK ; CLASSIFICATION ; CHILDHOOD ; INFANCY ; HEAD|
Purpose: The purpose of this study was to evaluate the outcomes of sclerotherapy of maxillofacial venous malformations by use of absolute ethanol and pingyangmycin (bleomycin A(5) hydrochloride).
Patients and Methods: We treated 23 consecutive patients with maxillofacial venous malformations by sclerotherapy with a combination of absolute ethanol and pingyangmycin under local anesthesia. The size of the lesions ranged from 2 cm x 2 cm to 12 cm x 10 cm. Venography showed the presence of large venous lakes. Venograms were obtained during the first procedure before and after injection of absolute ethanol (0-5-2.5 mL) to confirm the site of the nidus and assess the effect of sclerosis of the nidus and draining veins. Subsequently, 8 to 16 mg of pingyangmycin dissolved in 40 mL of saline solution was infused into the nidus by a dynamic infusion pump at a rate of 1 mL/min. If necessary, this procedure was repeated once in 2 or 4 weeks. The clinical outcomes and complications were evaluated.
Results: The duration of follow-up ranged from 6 to 37 months, with a mean of 20.3 months. Only 1 procedure was required in 3 patients, and the procedure was required to be repeated twice in 9 patients, 3 times in 7, and 4 times in 4. All the patients were satisfied with the treatment results, and excellent clinical results were obtained in 9 patients. There was no skin necrosis or nerve damage.
Conclusions: Percutaneous sclerotherapy with the combined use of absolute ethanol and pingyangmycin is a safe and effective treatment for maxillofacial venous malformations. (c) 2009 American Association of Oral and Maxillofacial Surgeons
|作者单位||1.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China|
2.Peking Univ, Sch Stomatol, Dept Oral Radiol, Beijing 100081, Peoples R China
|Liu, Yu,Liu, Denggao,Wang, Yixiang,et al. Clinical Study of Sclerotherapy of Maxillofacial Venous Malformation Using Absolute Ethanol and Pingyangmycin[J]. JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,2009,67(1):98-104.|
|APA||Liu, Yu,Liu, Denggao,Wang, Yixiang,Zhang, Wei,&Zhao, Fuyun.(2009).Clinical Study of Sclerotherapy of Maxillofacial Venous Malformation Using Absolute Ethanol and Pingyangmycin.JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,67(1),98-104.|
|MLA||Liu, Yu,et al."Clinical Study of Sclerotherapy of Maxillofacial Venous Malformation Using Absolute Ethanol and Pingyangmycin".JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 67.1(2009):98-104.|