学科主题临床医学
Genetic polymorphisms in centrobin and Nek2 are associated with breast cancer susceptibility in a Chinese Han population
Wang, Hui1; Xie, Yun-Tao2; Han, Ji-Yuan1; Ruan, Yuan1; Song, Ai-Ping1; Zheng, Li-Yuan1; Zhang, Wei-Zao1; Sajdik, Constantin3; Li, Yan1; Tian, Xin-Xia1; Fang, Wei-Gang1
关键词Centrobin Nek2 Single nucleotide polymorphism Haplotype Breast cancer
刊名BREAST CANCER RESEARCH AND TREATMENT
2012-11-01
DOI10.1007/s10549-012-2244-9
136期:1页:241-251
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]SINGLE-NUCLEOTIDE POLYMORPHISMS ; CENTROSOME AMPLIFICATION ; MITOTIC SPINDLES ; KINASE ; RISK ; ABERRATIONS ; SUBSTRATE ; PROTEIN ; NIP2/CENTROBIN ; INSTABILITY
英文摘要

Centrosome aberrations have been suggested to cause chromosomal instability and aneuploidy, and eventually promote cancer development. The Centrobin and Nek2 proteins interact with each other and both are involved in centrosome duplication and chromosome segregation. This study aimed to investigate whether genetic polymorphisms in these two genes may affect breast cancer susceptibility in Chinese Han population using a haplotype-based analysis. Five single nucleotide polymorphisms (SNPs) in centrobin and four SNPs in Nek2 were genotyped in 1,215 cases of infiltrating ductal breast cancer and 1,215 age-matched cancer-free controls from Chinese Han population. The results showed that CATCG haplotype of centrobin was strongly associated with decreased breast cancer risk (adjusted OR = 0.14, 95 % CI = 0.09-0.22), which was mainly driven by the C allele of SNP rs11650083 (A > C, located in exon 12, resulting in Pro578Gln). None of the individual SNPs in Nek2 was associated with breast cancer risk. However, haplotype GTAT of Nek2 was associated with increased risk of breast cancer (adjusted OR = 1.56, 95 % CI = 1.18-2.06) and its risk was significantly elevated among women with both family history of cancer and a longer menarche-first full-term pregnancy (FFTP) interval (> 11 years) (adjusted OR = 5.31, 95 % CI = 1.97-14.32). Furthermore, women harboring both at-risk haplotype GTAT of Nek2 and protective haplotype CATCG of centrobin were linked with decreased breast cancer risk, suggesting that the association between genetic variants of Nek2 and increased breast cancer risk was modified by genetic variants of centrobin. Our results indicate that genetic polymorphisms of centrobin and Nek2 are related to breast cancer susceptibility in Chinese Han women.

语种英语
WOS记录号WOS:000309940300023
项目编号81171961 ; 20110001110060
资助机构National Natural Science Foundation of China ; Ministry of Education of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63686
专题北京大学临床肿瘤学院_乳腺癌预防治疗中心
北京大学医学部管理机构_主任办公室党委办公室
北京大学基础医学院
作者单位1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Sino Austrian Ctr Biomarker Discovery, Dept Pathol,Minist Educ,Sch Basic Med Sci,Hlth Sc, Beijing 100191, Peoples R China
2.Peking Univ, Breast Ctr, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
3.Leopold Franzens Univ, Inst Analyt Chem & Radiochem, A-6020 Innsbruck, Austria
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GB/T 7714
Wang, Hui,Xie, Yun-Tao,Han, Ji-Yuan,et al. Genetic polymorphisms in centrobin and Nek2 are associated with breast cancer susceptibility in a Chinese Han population[J]. BREAST CANCER RESEARCH AND TREATMENT,2012,136(1):241-251.
APA Wang, Hui.,Xie, Yun-Tao.,Han, Ji-Yuan.,Ruan, Yuan.,Song, Ai-Ping.,...&Fang, Wei-Gang.(2012).Genetic polymorphisms in centrobin and Nek2 are associated with breast cancer susceptibility in a Chinese Han population.BREAST CANCER RESEARCH AND TREATMENT,136(1),241-251.
MLA Wang, Hui,et al."Genetic polymorphisms in centrobin and Nek2 are associated with breast cancer susceptibility in a Chinese Han population".BREAST CANCER RESEARCH AND TREATMENT 136.1(2012):241-251.
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