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学科主题: 临床医学
题名:
XPC Lys939Gln and Ala499Val polymorphisms in colorectal cancer susceptibility: a meta-analysis of case-control studies
作者: Liu, Chuan1; Yin, Qinghua2; Ying, Mingzhen1; Lin, Junhui1; Li, Lian2; Jiao, Guangjun3; Wang, Mei1; Wang, Yajie1
关键词: Meta-analysis ; XPC ; Polymorphisms ; Colorectal cancer
刊名: MOLECULAR BIOLOGY REPORTS
发表日期: 2014-02-01
DOI: 10.1007/s11033-013-2964-x
卷: 41, 期:2, 页:1171-1178
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: DNA-REPAIR GENES ; LUNG-CANCER ; CELL CARCINOMA ; RISK ; ASSOCIATIONS ; POPULATION ; LYS751GLN ; ALCOHOL ; SMOKING ; BIAS
英文摘要:

The XPC Lys939Gln and Ala499Val polymorphisms were likely to be involved with the development of colorectal cancer. However, there had been inconsistent reports of association. This meta-analysis of literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase and Web of Science for relevant articles with a time limit of December 2012. The strength of association between the XPC Lys939Gln and Ala499Val polymorphisms and colorectal cancer susceptibility were assessed by odds ratio (OR) with the corresponding 95 % confidence interval (95 % CI). This meta-analysis including six case-control studies evaluated the associations between the two XPC polymorphisms (Lys939Gln, Ala499Val) and colorectal cancer susceptibility. For XPC Lys939Gln, no obvious associations were found for all genetic models [CC vs AA: OR (95 % CI) = 1.12 (0.94-1.32); CA vs AA: OR (95 % CI) = 1.08 (0.94-1.24); the dominant model: OR (95 % CI) = 1.09 (0.97-1.23); the recessive model: OR (95 % CI) = 1.07 (0.92-1.25)]. For XPC Ala499Val, no obvious associations were also not found for all genetic models [TT vs CC: OR (95 % CI) = 0.84 (0.65-1.10); CT vs CC: OR (95 % CI) = 1.00 (0.86-1.15); the dominant model: OR (95 % CI) = 0.98 (0.85-1.12); the recessive model: OR (95 % CI) = 0.87 (0.67-1.12)]. This meta-analysis suggested that both the XPC Lys939Gln and Ala499Val polymorphisms were not risk factors for increasing colorectal cancer.

语种: 英语
所属项目编号: 81072175 ; 81102010 ; 81202096 ; 81372854 ; 114119a7500 ; 06DZ19505 ; 13NM1401504 ; 2009113 ; 2011198
项目资助者: Natural Science Foundation of The People&prime ; s Republic of China ; Shanghai Science and Technology Committee ; Research Programme of Shanghai Health Bureau
WOS记录号: WOS:000330860900067
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63689
Appears in Collections:北京大学第二临床医学院_骨肿瘤科_期刊论文

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作者单位: 1.Yueyang Second Peoples Hosp, Yueyang, Peoples R China
2.Second Mil Med Univ, Changhai Hosp, Dept Oncol, Shanghai 200433, Peoples R China
3.Peking Univ, Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Chuan,Yin, Qinghua,Ying, Mingzhen,et al. XPC Lys939Gln and Ala499Val polymorphisms in colorectal cancer susceptibility: a meta-analysis of case-control studies[J]. MOLECULAR BIOLOGY REPORTS,2014,41(2):1171-1178.
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