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学科主题: 临床医学
题名:
Malignant peripheral nerve sheath tumours of the spine: clinical manifestations, classification, treatment, and prognostic factors
作者: Zhu, Bin1; Liu, Xiaoguang1; Liu, Zhongjun1; Yang, Shaomin2; Liao, Hung-I1; Jiang, Liang1; Wei, Feng1
关键词: Diagnosis ; Malignant peripheral nerve sheath tumours ; Prognosis ; Spinal tumour ; Treatment
刊名: EUROPEAN SPINE JOURNAL
发表日期: 2012-05-01
DOI: 10.1007/s00586-011-2093-y
卷: 21, 期:5, 页:897-904
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Orthopedics
研究领域[WOS]: Neurosciences & Neurology ; Orthopedics
关键词[WOS]: OF-THE-LITERATURE ; THORACIC SPINE ; INTRAOSSEOUS SCHWANNOMA ; CERVICAL-SPINE
英文摘要:

To summarise our experience treating patients with spinal malignant peripheral nerve sheath tumours (MPNSTs).

We retrospectively reviewed the records of patients diagnosed with spinal MPNSTs who received surgical treatment from January 1998 to December 2009.

Postoperative follow-up data were available for 14/16 patients with spinal MPNSTs (7 men, 7 women; median age = 44 years [range: 23-68 years]). Eight of 14 (57.1%) patients had primary and 6/14 (42.9%) recurrent MPNSTs. A total of 12/14 (85.7%) patients underwent total tumour resection, whereas 2/14 (14.3%) patients underwent subtotal tumour resection. Malignancies were graded low in 4 (28.6%) and high in 10 (71.1%) cases. A total of 12/14 (85.7%) patients experienced tumour recurrence and 10/14 (71.4%) patients died during the course of follow-up. The 0.5- 1-, 3-, and 5-year survival rates were 64.3, 48.2, 32.1, and 21.4%, respectively. Overall survival was significantly associated with tumour malignant degree (P = 0.012).

Diagnosis of spinal MPNSTs should be made with reference to clinical, radiological, and pathological findings. Surgical resection is the best available option for treating spinal MPNST; however, postoperative prognosis is poor.

语种: 英语
WOS记录号: WOS:000303513600012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63690
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Orthopaed, Beijing 100191, Peoples R China
2.Peking Univ, Hlth & Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China

Recommended Citation:
Zhu, Bin,Liu, Xiaoguang,Liu, Zhongjun,et al. Malignant peripheral nerve sheath tumours of the spine: clinical manifestations, classification, treatment, and prognostic factors[J]. EUROPEAN SPINE JOURNAL,2012,21(5):897-904.
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