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Malignant peripheral nerve sheath tumours of the spine: clinical manifestations, classification, treatment, and prognostic factors
Zhu, Bin1; Liu, Xiaoguang1; Liu, Zhongjun1; Yang, Shaomin2; Liao, Hung-I1; Jiang, Liang1; Wei, Feng1
关键词Diagnosis Malignant peripheral nerve sheath tumours Prognosis Spinal tumour Treatment
刊名EUROPEAN SPINE JOURNAL
2012-05-01
DOI10.1007/s00586-011-2093-y
21期:5页:897-904
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Orthopedics
研究领域[WOS]Neurosciences & Neurology ; Orthopedics
关键词[WOS]OF-THE-LITERATURE ; THORACIC SPINE ; INTRAOSSEOUS SCHWANNOMA ; CERVICAL-SPINE
英文摘要

To summarise our experience treating patients with spinal malignant peripheral nerve sheath tumours (MPNSTs).

We retrospectively reviewed the records of patients diagnosed with spinal MPNSTs who received surgical treatment from January 1998 to December 2009.

Postoperative follow-up data were available for 14/16 patients with spinal MPNSTs (7 men, 7 women; median age = 44 years [range: 23-68 years]). Eight of 14 (57.1%) patients had primary and 6/14 (42.9%) recurrent MPNSTs. A total of 12/14 (85.7%) patients underwent total tumour resection, whereas 2/14 (14.3%) patients underwent subtotal tumour resection. Malignancies were graded low in 4 (28.6%) and high in 10 (71.1%) cases. A total of 12/14 (85.7%) patients experienced tumour recurrence and 10/14 (71.4%) patients died during the course of follow-up. The 0.5- 1-, 3-, and 5-year survival rates were 64.3, 48.2, 32.1, and 21.4%, respectively. Overall survival was significantly associated with tumour malignant degree (P = 0.012).

Diagnosis of spinal MPNSTs should be made with reference to clinical, radiological, and pathological findings. Surgical resection is the best available option for treating spinal MPNST; however, postoperative prognosis is poor.

语种英语
WOS记录号WOS:000303513600012
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63690
专题北京大学第三临床医学院_骨科
北京大学基础医学院
作者单位1.Peking Univ, Hosp 3, Dept Orthopaed, Beijing 100191, Peoples R China
2.Peking Univ, Hlth & Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
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Zhu, Bin,Liu, Xiaoguang,Liu, Zhongjun,et al. Malignant peripheral nerve sheath tumours of the spine: clinical manifestations, classification, treatment, and prognostic factors[J]. EUROPEAN SPINE JOURNAL,2012,21(5):897-904.
APA Zhu, Bin.,Liu, Xiaoguang.,Liu, Zhongjun.,Yang, Shaomin.,Liao, Hung-I.,...&Wei, Feng.(2012).Malignant peripheral nerve sheath tumours of the spine: clinical manifestations, classification, treatment, and prognostic factors.EUROPEAN SPINE JOURNAL,21(5),897-904.
MLA Zhu, Bin,et al."Malignant peripheral nerve sheath tumours of the spine: clinical manifestations, classification, treatment, and prognostic factors".EUROPEAN SPINE JOURNAL 21.5(2012):897-904.
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