|Malignant peripheral nerve sheath tumours of the spine: clinical manifestations, classification, treatment, and prognostic factors|
|Zhu, Bin1; Liu, Xiaoguang1; Liu, Zhongjun1; Yang, Shaomin2; Liao, Hung-I1; Jiang, Liang1; Wei, Feng1|
|关键词||Diagnosis Malignant peripheral nerve sheath tumours Prognosis Spinal tumour Treatment|
|刊名||EUROPEAN SPINE JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Clinical Neurology ; Orthopedics|
|研究领域[WOS]||Neurosciences & Neurology ; Orthopedics|
|关键词[WOS]||OF-THE-LITERATURE ; THORACIC SPINE ; INTRAOSSEOUS SCHWANNOMA ; CERVICAL-SPINE|
To summarise our experience treating patients with spinal malignant peripheral nerve sheath tumours (MPNSTs).
We retrospectively reviewed the records of patients diagnosed with spinal MPNSTs who received surgical treatment from January 1998 to December 2009.
Postoperative follow-up data were available for 14/16 patients with spinal MPNSTs (7 men, 7 women; median age = 44 years [range: 23-68 years]). Eight of 14 (57.1%) patients had primary and 6/14 (42.9%) recurrent MPNSTs. A total of 12/14 (85.7%) patients underwent total tumour resection, whereas 2/14 (14.3%) patients underwent subtotal tumour resection. Malignancies were graded low in 4 (28.6%) and high in 10 (71.1%) cases. A total of 12/14 (85.7%) patients experienced tumour recurrence and 10/14 (71.4%) patients died during the course of follow-up. The 0.5- 1-, 3-, and 5-year survival rates were 64.3, 48.2, 32.1, and 21.4%, respectively. Overall survival was significantly associated with tumour malignant degree (P = 0.012).
Diagnosis of spinal MPNSTs should be made with reference to clinical, radiological, and pathological findings. Surgical resection is the best available option for treating spinal MPNST; however, postoperative prognosis is poor.
|作者单位||1.Peking Univ, Hosp 3, Dept Orthopaed, Beijing 100191, Peoples R China|
2.Peking Univ, Hlth & Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
|Zhu, Bin,Liu, Xiaoguang,Liu, Zhongjun,et al. Malignant peripheral nerve sheath tumours of the spine: clinical manifestations, classification, treatment, and prognostic factors[J]. EUROPEAN SPINE JOURNAL,2012,21(5):897-904.|
|APA||Zhu, Bin.,Liu, Xiaoguang.,Liu, Zhongjun.,Yang, Shaomin.,Liao, Hung-I.,...&Wei, Feng.(2012).Malignant peripheral nerve sheath tumours of the spine: clinical manifestations, classification, treatment, and prognostic factors.EUROPEAN SPINE JOURNAL,21(5),897-904.|
|MLA||Zhu, Bin,et al."Malignant peripheral nerve sheath tumours of the spine: clinical manifestations, classification, treatment, and prognostic factors".EUROPEAN SPINE JOURNAL 21.5(2012):897-904.|