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Pharmacokinetics and radiation dosimetry of Tc-99m-3PRGD(2) in healthy individuals: A pilot study
Cheng Guanghui1; Gao Shi1; Ji Tiefeng1; Ma Qingjie1; Jia Bing2; Chen Zuowei3; Wang Qing1
关键词Tc-99m-3PRGD(2) Integrin alpha(v)beta(3) Pharmacokinetic Dosimetry
刊名NUCLEAR SCIENCE AND TECHNIQUES
2012-12-20
23期:6页:349-354
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nuclear Science & Technology ; Physics, Nuclear
研究领域[WOS]Nuclear Science & Technology ; Physics
关键词[WOS]INTEGRIN ALPHA(V)BETA(3) EXPRESSION ; POSITRON-EMISSION-TOMOGRAPHY ; CANCER-PATIENTS ; BREAST-CANCER ; RGD DIMERS ; ANGIOGENESIS ; TC-99M-NC100692 ; MICROSCOPY ; RECEPTOR ; LINKERS
英文摘要

Te-99m-3PRGD(2) is a new SPECT radiotracer for several tumor imaging with high uptake where integrin alpha(v)beta(3) is highly expressed. This pilot study was to assess the safety, biodistribution and radiation dosimetry of Tc-99m-3PRGD(2) in healthy volunteers. The 10 healthy male volunteers were injected with Tc-99m-3PRGD(2) (786.7 +/- 55.8 MBq, 19.1-24.2 mCi). Baseline measurements of vital signs, laboratory safety tests and 12-lead electrocardiogram were recorded before and after injection. Blood and urine samples were collected and radiation counts were obtained at various time points. Whole-body scans and ROIs of identified organs were used for visual analysis and estimating the radiation dosimetry. No adverse reactions were found during the study. Tc-99m-3PRGD(2) exhibited a rapid clearance from the blood with less than 45% of the initial dosage at 10 min after injection and gradual increasing radioactivity in urine with (52.9 +/- 6)% of original dose at 1440 mm. The whole-body imaging showed high radioactive accumulation in bladder. And the highest Tc-99m-3PRGD(2) uptake was found in the kidneys (3.50x10(-2) mSv/MBq). The Tc-99m-3PRGD(2) exhibited good pharmacokinetic properties and little radiation burden. This study showed that Tc-99m-3PRGD(2) would be a safe and attractive SPECT agent in clinic applications.

语种英语
WOS记录号WOS:000327048000006
项目编号81271606 ; 201015185 ; 201201041 ; 201102154
资助机构National Natural Science Foundation of China (NSFC) ; Research Fund of Science and Technology Department of Jilin Province ; Research Fund of Shenzhen Sci-tech Department of Guangdong Province
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63691
专题北京大学医药卫生分析中心
北京大学基础医学院
作者单位1.Jilin Univ, China Japan Union Hosp, Changchun 130033, Peoples R China
2.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
3.Peoples Hosp Shenzhen, Dept Nucl Med, Shenzhen 518020, Peoples R China
推荐引用方式
GB/T 7714
Cheng Guanghui,Gao Shi,Ji Tiefeng,et al. Pharmacokinetics and radiation dosimetry of Tc-99m-3PRGD(2) in healthy individuals: A pilot study[J]. NUCLEAR SCIENCE AND TECHNIQUES,2012,23(6):349-354.
APA Cheng Guanghui.,Gao Shi.,Ji Tiefeng.,Ma Qingjie.,Jia Bing.,...&Wang Qing.(2012).Pharmacokinetics and radiation dosimetry of Tc-99m-3PRGD(2) in healthy individuals: A pilot study.NUCLEAR SCIENCE AND TECHNIQUES,23(6),349-354.
MLA Cheng Guanghui,et al."Pharmacokinetics and radiation dosimetry of Tc-99m-3PRGD(2) in healthy individuals: A pilot study".NUCLEAR SCIENCE AND TECHNIQUES 23.6(2012):349-354.
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