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学科主题: 药学
题名:
Induction of apoptosis and G(2)/M cell cycle arrest by gleditsioside E from Gleditsia sinensis in HL-60 cells
作者: Zhong, L; Qu, GQ; Li, P; Han, J; Guo, D
刊名: PLANTA MEDICA
发表日期: 2003-06-01
卷: 69, 期:6, 页:561-563
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: TRITERPENOIDAL SAPONINS ; ASSAY
英文摘要:

Gleditsioside E, a triterpene saponin isolated from Gleditsia sinensis, showed significant cytotoxicity against Bel-7402, BGC-823, HeLa, HL-60 and MCF-7 cell lines. The results of flow cytometry with annexin V-FITC/PI double staining proved that gleditsioside E mainly induced early apoptosis in HL-60 cells. Gleditisioside E treatment resulted in a prominent increase of the G(2)/M population in HL-60 cells, and an accumulation of the sub-G(1) (hypoploid) peak was observed.

语种: 英语
WOS记录号: WOS:000184144600018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63693
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Zhong, L,Qu, GQ,Li, P,et al. Induction of apoptosis and G(2)/M cell cycle arrest by gleditsioside E from Gleditsia sinensis in HL-60 cells[J]. PLANTA MEDICA,2003,69(6):561-563.
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