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Induction of apoptosis and G(2)/M cell cycle arrest by gleditsioside E from Gleditsia sinensis in HL-60 cells
Zhong, L; Qu, GQ; Li, P; Han, J; Guo, D
刊名PLANTA MEDICA
2003-06-01
69期:6页:561-563
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]TRITERPENOIDAL SAPONINS ; ASSAY
英文摘要

Gleditsioside E, a triterpene saponin isolated from Gleditsia sinensis, showed significant cytotoxicity against Bel-7402, BGC-823, HeLa, HL-60 and MCF-7 cell lines. The results of flow cytometry with annexin V-FITC/PI double staining proved that gleditsioside E mainly induced early apoptosis in HL-60 cells. Gleditisioside E treatment resulted in a prominent increase of the G(2)/M population in HL-60 cells, and an accumulation of the sub-G(1) (hypoploid) peak was observed.

语种英语
WOS记录号WOS:000184144600018
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63693
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhong, L,Qu, GQ,Li, P,et al. Induction of apoptosis and G(2)/M cell cycle arrest by gleditsioside E from Gleditsia sinensis in HL-60 cells[J]. PLANTA MEDICA,2003,69(6):561-563.
APA Zhong, L,Qu, GQ,Li, P,Han, J,&Guo, D.(2003).Induction of apoptosis and G(2)/M cell cycle arrest by gleditsioside E from Gleditsia sinensis in HL-60 cells.PLANTA MEDICA,69(6),561-563.
MLA Zhong, L,et al."Induction of apoptosis and G(2)/M cell cycle arrest by gleditsioside E from Gleditsia sinensis in HL-60 cells".PLANTA MEDICA 69.6(2003):561-563.
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