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学科主题: 基础医学
题名:
Effects of Compound Dan-shen Root Dropping Pill on hemorheology in high-fat diet induced hyperlipidemia in dogs
作者: Guo, J; Zhang, L; Jiang, YH; Zeng, Z; Sun, DG; Ka, WB; Zheng, J; Guo, ZX; Wen, ZY
关键词: hyperlipidemia ; Compound Dan-shen Root Dropping Pill ; hemorheology
刊名: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
发表日期: 2005
卷: 32, 期:1, 页:19-30
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: CORONARY-HEART-DISEASE ; RED-BLOOD-CELLS ; OSMOTIC FRAGILITY ; FLOW FIELD ; ERYTHROCYTE DEFORMABILITY ; LIPID-PEROXIDATION ; FREE-RADICALS ; LOW-VISCOSITY ; RBC MEMBRANE ; ATHEROSCLEROSIS
英文摘要:

The purpose of this study was to examine the effects of Compound Dan-shen Root Dropping Pill (CDRDP) (Tasly Group, Tianjing, China) on hemorheology and biorheology of dogs suffering from hyperlipidemia induced by high-fat diet. Eighteen dogs were randomly divided into two groups: the high-fat diet group (H group); the control group (C group), fed with a standard laboratory diet. Six month later, six dogs in the H group were chosen as the drug-taking group (D group), to which CDRDP was administered, fed with the same diet as H group. In the 4th month, blood was taken from the veins of the dogs, and blood triglyceride (TG), total cholesterol (TC), RBC hemorheological indexes as well as malondialdehyde (MDA), glutathione transferase (GSH-ST) and superoxide dismutase (SOD) activities in plasma and erythrocytes were measured. Compared with H group, TC, TG, plasma MDA levels, the whole blood viscosity, RBC osmotic fragility and the value of CHOL (cholesterol)/PL (phospholipid) of the membrane of D group decreased, however, erythrocyte GSH-ST, histopathological changes in liver, deformation index (DI), orientation index (DI)(or), small deformation index (DI)(d), electrophoresis ratio and microfluidity of the membrane lipid bilayer of RBCs, increased distinctly. CDRDP can improve micro-hemorheological characteristics, therefore has a significant therapy application of hyperlipidemia.

语种: 英语
WOS记录号: WOS:000226493500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63694
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Biophys, Sch Basic Med Sci,Hemorheol Ctr, Beijing 100083, Peoples R China
2.254 Hosp Tianjing Liberat Army, Dept Cardiol, Tianjin 300142, Peoples R China
3.Tasly Grp, Tianjin 300402, Peoples R China

Recommended Citation:
Guo, J,Zhang, L,Jiang, YH,et al. Effects of Compound Dan-shen Root Dropping Pill on hemorheology in high-fat diet induced hyperlipidemia in dogs[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2005,32(1):19-30.
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