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学科主题: 药物依赖
题名:
Effects of early postnatal sibling deprivation on anxiety and vulnerability to cocaine in offspring rats
作者: Li, Yan-Qin1; Wang, Xiao-Yi1; Zhai, Hai-feng1; Zheng, Yong-Qiu1; Zhang, Xiang Yang2; Kosten, Therese2; Lu, Lin1
关键词: early postnatal sibling deprivation ; anxiety behavior ; natural reward ; conditioned place preference ; cocaine
刊名: PSYCHOPHARMACOLOGY
发表日期: 2008-08-01
DOI: 10.1007/s00213-008-1169-9
卷: 199, 期:2, 页:245-253
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: NEONATAL MATERNAL SEPARATION ; CONDITIONED PLACE PREFERENCE ; ADULT MALE RATS ; FEMALE RATS ; NEUROENDOCRINE RESPONSES ; BEHAVIORAL SENSITIZATION ; COGNITIVE-DEVELOPMENT ; STRESS EXPERIENCE ; MENTAL-HEALTH ; CARE
英文摘要:

Rationale Early-life experience has long-term consequences on affective behavior and drug abuse in adults. While many manipulations used to study these consequences alter mother-infant interactions, the effects of sibling interactions are less well characterized.

Objectives To examine the long-term effects of early postnatal sibling deprivation (EPSD) on anxiety-like behavior, sucrose preference and behavioral responses to cocaine in adult rats.

Materials and methods After EPSD manipulation, in which litters were culled to one pup on postnatal day 1 (PN1) or 7 (PN7), the dams′ maternal behavior was observed. After the pups reached adulthood, we tested their behavioral responses in the elevated plus maze and sucrose consumption, and to cocaine conditioned place preference and cocaine sensitization.

Results The pups with EPSD on PN1 received more maternal licking/grooming during the first postnatal week. EPSD on PN1 but not PN7 enhanced locomotor activity in the open field test and exploration of open arms in the elevated plus maze in both female and male offspring. While EPSD had no effect on sucrose intake in adult rats, it decreased vulnerability to cocaine sensitization and cocaine conditioned place preference in male but not female rats.

Conclusion Our findings that early postnatal sibling deprivation influences maternal licking/grooming behavior, as well as anxiety-like behavior and vulnerability to drugs in pups that have grown to adulthood, suggests that both sibling interaction and maternal behavior, play critical roles in individual development.

语种: 英语
WOS记录号: WOS:000257383100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63697
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Baylor Coll Med, VA Med Ctr, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA

Recommended Citation:
Li, Yan-Qin,Wang, Xiao-Yi,Zhai, Hai-feng,et al. Effects of early postnatal sibling deprivation on anxiety and vulnerability to cocaine in offspring rats[J]. PSYCHOPHARMACOLOGY,2008,199(2):245-253.
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