IR@PKUHSC  > 北京大学第一临床医学院  > 普通外科
学科主题临床医学
Prognostic values of the miR-17-92 cluster and its paralogs in colon cancer
Yu, Ge; Tang, Jian-Qiang; Tian, Mao-Lin; Li, Hui; Wang, Xin; Wu, Tao; Zhu, Jing; Huang, Shan-Jun; Wan, Yuan-Lian
关键词colon cancer miR-17-92 cluster prognosis
刊名JOURNAL OF SURGICAL ONCOLOGY
2012-09-01
DOI10.1002/jso.22138
106期:3页:232-237
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Surgery
研究领域[WOS]Oncology ; Surgery
关键词[WOS]MICRORNA EXPRESSION ; COLORECTAL-CANCER ; CELL-PROLIFERATION ; GENE ; ADENOCARCINOMA ; POLYCISTRON ; PROFILES ; IDENTIFICATION ; PROGRESSION ; SIGNATURE
英文摘要

Background MicroRNAs have been shown to offer great potential in both the diagnosis and prognosis of cancer. Despite the well-established role of the miR-17-92 in cancer formation and progression, the contribution of each individual miRNA remains to be characterized. Thus, we investigated whether deregulation of the miR-17-92 associated with colon cancer prognosis. Methods Expression levels of the miR-17-92 cluster and its paralogs were determined in 48 colon tumor and 48 paired normal tissues by real-time qRT-PCR. Associations with miRNA expression, age, sex, TNM staging, and survival prognosis were evaluated. Results MiR-17-92 cluster and its paralogs were significantly overexpressed in colon tumor. No significant associations were found between the deregulation of certain miRNAs and the clinical and pathologic characteristics observed in patients. KaplanMeier curves demonstrated significantly reduced overall survival in patients expressing high levels of miR-17. In multivariate Cox models, miR-17 overexpression (HR 2.67; P?=?0.007) and TNM staging (HR 8.87; P?=?0.002) were significantly associated with a risk of death. Conclusions The miR-17-92 cluster and its paralogs were significantly elevated in patients with colon cancer, and heightened expression of miR-17 was associated with poor survival. Moreover, miR-17 and TNM staging were both identified as significant, but independent, prognostic biomarkers in colon cancer. J. Surg. Oncol. 2012; 106:232-237. (c) 2011 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000307165600004
项目编号30801092 ; 30872469
资助机构National Natural and Science Foundation of China ; National Natural Science of Youth Foundation of China ; "985" Project Foundation of Peking University
引用统计
被引频次:49[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63702
专题北京大学第一临床医学院_普通外科
作者单位Peking Univ, Hosp 1, Dept Gen Surg, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Yu, Ge,Tang, Jian-Qiang,Tian, Mao-Lin,et al. Prognostic values of the miR-17-92 cluster and its paralogs in colon cancer[J]. JOURNAL OF SURGICAL ONCOLOGY,2012,106(3):232-237.
APA Yu, Ge.,Tang, Jian-Qiang.,Tian, Mao-Lin.,Li, Hui.,Wang, Xin.,...&Wan, Yuan-Lian.(2012).Prognostic values of the miR-17-92 cluster and its paralogs in colon cancer.JOURNAL OF SURGICAL ONCOLOGY,106(3),232-237.
MLA Yu, Ge,et al."Prognostic values of the miR-17-92 cluster and its paralogs in colon cancer".JOURNAL OF SURGICAL ONCOLOGY 106.3(2012):232-237.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yu, Ge]的文章
[Tang, Jian-Qiang]的文章
[Tian, Mao-Lin]的文章
百度学术
百度学术中相似的文章
[Yu, Ge]的文章
[Tang, Jian-Qiang]的文章
[Tian, Mao-Lin]的文章
必应学术
必应学术中相似的文章
[Yu, Ge]的文章
[Tang, Jian-Qiang]的文章
[Tian, Mao-Lin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。