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学科主题: 公共卫生
题名:
Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature
作者: Liu, Cong1; Xu, Junhui2; Chen, Yahong3; Guo, Xinbiao2; Zheng, Yinan4; Wang, Qianfei9; Chen, Yiyong2; Ni, Yang2; Zhu, Yidan2; Joyce, Brian Thomas5,6; Baccarelli, Andrea7; Deng, Furong2; Zhang, Wei5,8; Hou, Lifang5,8
关键词: Histone modification ; H3K27ac ; Particulate matter ; Epigenetics ; Environmental health ; Gene regulation
刊名: ENVIRONMENTAL HEALTH
发表日期: 2015-08-15
DOI: 10.1186/s12940-015-0052-5
卷: 14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]: PARTICULATE AIR-POLLUTION ; OXIDATIVE STRESS ; CELL-TYPES ; DISEASE ; ASSOCIATION ; CHROMATIN ; VARIANTS ; FINE ; INFLAMMATION ; DISORDERS
英文摘要:

Background: Current studies of environmental health suggest a link between air pollution components, such as particulate matter (PM), and various diseases. However, the specific genes and regulatory mechanisms implicated in PM-induced diseases remain largely unknown. Epigenetic systems such as covalent modification of histones in chromatin may mediate environmental factors in gene regulation. Investigating the relationships between PM exposure and histone modification status may help understand the mechanisms underlying environment-associated health conditions.

Methods: In this study, we obtained genome-wide profiles of H3K27ac (histone 3 lysine 27 acetylation), known to be an active gene regulatory histone modification marker, in blood samples collected from four Chinese individuals exposed to high or low PM2.5 (particles with diameters up to 2.5 mu m).

Results: The genome-wide chromatin immunoprecipitation sequencing (ChIP-Seq) data indicated a comprehensive differential H3K27ac landscape across the individual genomes, which was associated with high PM2.5. Moreover, a substantial number of these PM2.5-associated differential H3K27ac markers were in genes involved in immune cell activation, potentially linking these epigenetic changes with air pollution-induced immune and inflammatory responses.

Conclusions: Our study provides the first genome-wide characterization of H3K27ac profiles in individuals subjected to different exposure levels of PM2.5. Future systematic investigations of the relationships between air pollutants and histone modifications in large population samples are warranted to elucidate the contributions of histone modifications to environment-associated diseases.

语种: 英语
所属项目编号: ES00002 ; R21ES020010 ; R21HG006367 ; P30CA060553
项目资助者: National Institutes of Health ; Robert H. Lurie Comprehensive Cancer Center-Developmental Funds
WOS记录号: WOS:000359518100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63704
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Resp Dept, Beijing 100191, Peoples R China
2.Univ Illinois, Dept Bioengn, Chicago, IL USA
3.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
4.Northwestern Univ, Feinberg Sch Med, Inst Publ Hlth & Med, Chicago, IL 60611 USA
5.Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA
6.Univ Illinois, Sch Publ Hlth, Div Epidemiol Biostat, Chicago, IL USA
7.Harvard Univ, TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA
8.Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA
9.Chinese Acad Sci, Beijing Inst Genom, Key Lab Genom & Precis Med, Beijing 100101, Peoples R China

Recommended Citation:
Liu, Cong,Xu, Junhui,Chen, Yahong,et al. Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature[J]. ENVIRONMENTAL HEALTH,2015,14.
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