IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature
Liu, Cong1; Xu, Junhui2; Chen, Yahong3; Guo, Xinbiao2; Zheng, Yinan4; Wang, Qianfei9; Chen, Yiyong2; Ni, Yang2; Zhu, Yidan2; Joyce, Brian Thomas5,6; Baccarelli, Andrea7; Deng, Furong2; Zhang, Wei5,8; Hou, Lifang5,8
关键词Histone modification H3K27ac Particulate matter Epigenetics Environmental health Gene regulation
刊名ENVIRONMENTAL HEALTH
2015-08-15
DOI10.1186/s12940-015-0052-5
14
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Public, Environmental & Occupational Health
资助者National Institutes of Health ; Robert H. Lurie Comprehensive Cancer Center-Developmental Funds ; National Institutes of Health ; Robert H. Lurie Comprehensive Cancer Center-Developmental Funds
研究领域[WOS]Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]PARTICULATE AIR-POLLUTION ; OXIDATIVE STRESS ; CELL-TYPES ; DISEASE ; ASSOCIATION ; CHROMATIN ; VARIANTS ; FINE ; INFLAMMATION ; DISORDERS
英文摘要

Background: Current studies of environmental health suggest a link between air pollution components, such as particulate matter (PM), and various diseases. However, the specific genes and regulatory mechanisms implicated in PM-induced diseases remain largely unknown. Epigenetic systems such as covalent modification of histones in chromatin may mediate environmental factors in gene regulation. Investigating the relationships between PM exposure and histone modification status may help understand the mechanisms underlying environment-associated health conditions.

Methods: In this study, we obtained genome-wide profiles of H3K27ac (histone 3 lysine 27 acetylation), known to be an active gene regulatory histone modification marker, in blood samples collected from four Chinese individuals exposed to high or low PM2.5 (particles with diameters up to 2.5 mu m).

Results: The genome-wide chromatin immunoprecipitation sequencing (ChIP-Seq) data indicated a comprehensive differential H3K27ac landscape across the individual genomes, which was associated with high PM2.5. Moreover, a substantial number of these PM2.5-associated differential H3K27ac markers were in genes involved in immune cell activation, potentially linking these epigenetic changes with air pollution-induced immune and inflammatory responses.

Conclusions: Our study provides the first genome-wide characterization of H3K27ac profiles in individuals subjected to different exposure levels of PM2.5. Future systematic investigations of the relationships between air pollutants and histone modifications in large population samples are warranted to elucidate the contributions of histone modifications to environment-associated diseases.

语种英语
所属项目编号ES00002 ; R21ES020010 ; R21HG006367 ; P30CA060553
资助者National Institutes of Health ; Robert H. Lurie Comprehensive Cancer Center-Developmental Funds ; National Institutes of Health ; Robert H. Lurie Comprehensive Cancer Center-Developmental Funds
WOS记录号WOS:000359518100001
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63704
专题北京大学公共卫生学院
作者单位1.Peking Univ, Hosp 3, Resp Dept, Beijing 100191, Peoples R China
2.Univ Illinois, Dept Bioengn, Chicago, IL USA
3.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
4.Northwestern Univ, Feinberg Sch Med, Inst Publ Hlth & Med, Chicago, IL 60611 USA
5.Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA
6.Univ Illinois, Sch Publ Hlth, Div Epidemiol Biostat, Chicago, IL USA
7.Harvard Univ, TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA
8.Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA
9.Chinese Acad Sci, Beijing Inst Genom, Key Lab Genom & Precis Med, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Liu, Cong,Xu, Junhui,Chen, Yahong,et al. Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature[J]. ENVIRONMENTAL HEALTH,2015,14.
APA Liu, Cong.,Xu, Junhui.,Chen, Yahong.,Guo, Xinbiao.,Zheng, Yinan.,...&Hou, Lifang.(2015).Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature.ENVIRONMENTAL HEALTH,14.
MLA Liu, Cong,et al."Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature".ENVIRONMENTAL HEALTH 14(2015).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Cong]的文章
[Xu, Junhui]的文章
[Chen, Yahong]的文章
百度学术
百度学术中相似的文章
[Liu, Cong]的文章
[Xu, Junhui]的文章
[Chen, Yahong]的文章
必应学术
必应学术中相似的文章
[Liu, Cong]的文章
[Xu, Junhui]的文章
[Chen, Yahong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。