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IR@PKUHSC  > 北京大学临床肿瘤学院  > 病理科  > 期刊论文
学科主题: 临床医学
题名:
Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives
作者: Cheung, Annie N. Y.1; Zhang, Hui Juan1,2; Xue, Wei Chen3; Siu, Michelle K. Y.1
关键词: choriocarcinoma ; dedifferentiation ; germ cell tumors ; gestational trophoblastic disease ; stem cell
刊名: FUTURE ONCOLOGY
发表日期: 2009-03-01
DOI: 10.2217/14796694.5.2.217
卷: 5, 期:2, 页:217-231
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: GESTATIONAL-TROPHOBLASTIC-DISEASE ; TUMOR-SUPPRESSOR GENE ; HUMAN CHORIONIC-GONADOTROPIN ; PURE NONGESTATIONAL CHORIOCARCINOMA ; COMPARATIVE GENOMIC HYBRIDIZATION ; COMPLETE HYDATIDIFORM MOLE ; IN-NORMAL-PLACENTA ; DIFFERENTIAL-DIAGNOSIS ; CLINICOPATHOLOGICAL PARAMETERS ; INTERMEDIATE TROPHOBLAST
英文摘要:

Choriocarcinoma is a unique malignant neoplasm composed of mononuclear cytotrophoblasts and multinucleated syncytiotrophoblasts that produce human chorionic gonadotrophin. Choriocarcinoma can occur after a pregnancy, as a component of germ cell tumors, or in association with a poorly differentiated somatic carcinoma, each with distinct clinical features. Cytogenetic and molecular studies, predominantly on gestational choriocarcinoma, revealed the impact of oncogenes, tumor suppressor genes and imprinting genes on its pathogenesis. The role of stem cells in various types of choriocarcinoma has been studied recently. This review will discuss how such knowledge can enhance our understanding of the pathogenesis of choriocarcinoma, enable exploration of novel anti-choriocarcinoma targeted therapy and possibly improve our insight on embryological and placental development.

语种: 英语
WOS记录号: WOS:000264469800015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63707
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
2.Jiao Tong Univ, Int Peace Matern & Child Hlth Hosp, Dept Pathol, Shanghai, Peoples R China
3.Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol, Dept Pathol, Beijing, Peoples R China

Recommended Citation:
Cheung, Annie N. Y.,Zhang, Hui Juan,Xue, Wei Chen,et al. Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives[J]. FUTURE ONCOLOGY,2009,5(2):217-231.
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