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学科主题临床医学
Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives
Cheung, Annie N. Y.1; Zhang, Hui Juan1,2; Xue, Wei Chen3; Siu, Michelle K. Y.1
关键词choriocarcinoma dedifferentiation germ cell tumors gestational trophoblastic disease stem cell
刊名FUTURE ONCOLOGY
2009-03-01
DOI10.2217/14796694.5.2.217
5期:2页:217-231
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]GESTATIONAL-TROPHOBLASTIC-DISEASE ; TUMOR-SUPPRESSOR GENE ; HUMAN CHORIONIC-GONADOTROPIN ; PURE NONGESTATIONAL CHORIOCARCINOMA ; COMPARATIVE GENOMIC HYBRIDIZATION ; COMPLETE HYDATIDIFORM MOLE ; IN-NORMAL-PLACENTA ; DIFFERENTIAL-DIAGNOSIS ; CLINICOPATHOLOGICAL PARAMETERS ; INTERMEDIATE TROPHOBLAST
英文摘要

Choriocarcinoma is a unique malignant neoplasm composed of mononuclear cytotrophoblasts and multinucleated syncytiotrophoblasts that produce human chorionic gonadotrophin. Choriocarcinoma can occur after a pregnancy, as a component of germ cell tumors, or in association with a poorly differentiated somatic carcinoma, each with distinct clinical features. Cytogenetic and molecular studies, predominantly on gestational choriocarcinoma, revealed the impact of oncogenes, tumor suppressor genes and imprinting genes on its pathogenesis. The role of stem cells in various types of choriocarcinoma has been studied recently. This review will discuss how such knowledge can enhance our understanding of the pathogenesis of choriocarcinoma, enable exploration of novel anti-choriocarcinoma targeted therapy and possibly improve our insight on embryological and placental development.

语种英语
WOS记录号WOS:000264469800015
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63707
专题北京大学临床肿瘤学院_病理科
作者单位1.Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
2.Jiao Tong Univ, Int Peace Matern & Child Hlth Hosp, Dept Pathol, Shanghai, Peoples R China
3.Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol, Dept Pathol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Cheung, Annie N. Y.,Zhang, Hui Juan,Xue, Wei Chen,et al. Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives[J]. FUTURE ONCOLOGY,2009,5(2):217-231.
APA Cheung, Annie N. Y.,Zhang, Hui Juan,Xue, Wei Chen,&Siu, Michelle K. Y..(2009).Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives.FUTURE ONCOLOGY,5(2),217-231.
MLA Cheung, Annie N. Y.,et al."Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives".FUTURE ONCOLOGY 5.2(2009):217-231.
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