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学科主题: 临床医学
题名:
Protein expression of osteopontin in tumor tissues is an independent prognostic indicator in gastric cancer
作者: Dai, Ni; Bao, Quan; Lu, Aiping; Li, Jiyou
关键词: osteopontin ; gastric cancer ; prognosis ; immunohistochemistry
刊名: ONCOLOGY
发表日期: 2007
DOI: 10.1159/000111108
卷: 72, 期:1-2, 页:89-96
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CELL LUNG-CANCER ; BREAST-CANCER ; METASTASIS ; THERAPY ; ANGIOGENESIS ; PROGRESSION ; CARCINOMA ; MIGRATION ; SURVIVAL ; ADHESION
英文摘要:

Objective: Osteopontin has been shown to facilitate the progression and metastasis of malignancies and to be of prognostic value in several human cancers. In gastric cancer, the protein expression of osteopontin has been found to be correlated with tumor invasion and metastasis, but data on its prognostic value are lacking. The aim of this study was to classify the prognostic significance of osteopontin in gastric cancer. Method: In this retrospective study, 306 tumor tissue samples resected from patients with gastric cancer were investigated by staining with a commercial polyclonal antibody against osteopontin. Results: Positive osteopontin expression (>5% of the cancer cell cytoplasm positive) was found in 132 (43.1%) of 306 stained tumors. High osteopontin expression correlated with deep invasion, lymph node metastasis, distant metastasis and higher TNM stage. Patients with osteopontin-positive expression had poorer overall and disease-free survivals than those with negative expression (p < 0.001 for both). Multivariate analysis revealed osteopontin expression as an independent prognostic indicator of poor disease-free and overall survival in patients with gastric cancer, particularly for survival in TNM stages II (p < 0.05) and III (p < 0.01) patients. Conclusion: Osteopontin protein expression was confirmed as a new independent predictor of tumor recurrence and poor prognosis in patients with gastric cancer. Copyright (c) 2007 S. Karger AG, Basel.

语种: 英语
WOS记录号: WOS:000251138300015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63708
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Peking Univ, Beijing Canc Hosp, Sch Oncol, Dept Pathol, Beijing 100871, Peoples R China
2.Peking Univ, Beijing Canc Hosp, Sch Oncol, Dept Surg, Beijing 100871, Peoples R China

Recommended Citation:
Dai, Ni,Bao, Quan,Lu, Aiping,et al. Protein expression of osteopontin in tumor tissues is an independent prognostic indicator in gastric cancer[J]. ONCOLOGY,2007,72(1-2):89-96.
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