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学科主题: 临床医学
题名:
The leader sequence triggers and enhances several functions of clusterin and is instrumental in the progression of human prostate cancer in vivo and in vitro
作者: Zhang, Qiang; Zhou, Wei; Kundu, Shilajit; Jang, Thomas L.; Yang, Ximing; Pins, Michael; Smith, Norm; Jovanovic, Borko; Xin, Dianqi; Liang, Lili; Guo, Yinglu; Lee, Chung
关键词: apoptosis ; cyto-protection ; leader sequence ; clusterin ; prostate cancer
刊名: BJU INTERNATIONAL
发表日期: 2006-08-01
DOI: 10.1111/j.1464-410X.2006.06263.x
卷: 98, 期:2, 页:452-460
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: SULFATED GLYCOPROTEIN-2 CLUSTERIN ; NECROSIS-FACTOR-ALPHA ; GROWTH-FACTOR-BETA ; RETE TESTIS FLUID ; CELL-DEATH ; APOLIPOPROTEIN-J/CLUSTERIN ; REPRODUCTIVE-TRACT ; ANTIAPOPTOTIC GENE ; SGP-2 CLUSTERIN ; HEAT-SHOCK
英文摘要:

To investigate the role of the leader sequence (which during clusterin biosynthesis facilitates its proper post-translational processing and secretion) in the functional activities of clusterin, a ubiquitous secretory glycoprotein with many biological functions, reported to be pro-apoptotic and anti-apoptotic in target cells, but for which the dual mechanism remains unclear.

语种: 英语
WOS记录号: WOS:000238790900040
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63711
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Inst Urol, Beijing, Peoples R China
2.Northwestern Univ, Dept Urol, Feinberg Sch Med, Chicago, IL 60611 USA
3.Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA
4.Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA
5.Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

Recommended Citation:
Zhang, Qiang,Zhou, Wei,Kundu, Shilajit,et al. The leader sequence triggers and enhances several functions of clusterin and is instrumental in the progression of human prostate cancer in vivo and in vitro[J]. BJU INTERNATIONAL,2006,98(2):452-460.
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