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学科主题临床医学
The leader sequence triggers and enhances several functions of clusterin and is instrumental in the progression of human prostate cancer in vivo and in vitro
Zhang, Qiang; Zhou, Wei; Kundu, Shilajit; Jang, Thomas L.; Yang, Ximing; Pins, Michael; Smith, Norm; Jovanovic, Borko; Xin, Dianqi; Liang, Lili; Guo, Yinglu; Lee, Chung
关键词apoptosis cyto-protection leader sequence clusterin prostate cancer
刊名BJU INTERNATIONAL
2006-08-01
DOI10.1111/j.1464-410X.2006.06263.x
98期:2页:452-460
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]SULFATED GLYCOPROTEIN-2 CLUSTERIN ; NECROSIS-FACTOR-ALPHA ; GROWTH-FACTOR-BETA ; RETE TESTIS FLUID ; CELL-DEATH ; APOLIPOPROTEIN-J/CLUSTERIN ; REPRODUCTIVE-TRACT ; ANTIAPOPTOTIC GENE ; SGP-2 CLUSTERIN ; HEAT-SHOCK
英文摘要

To investigate the role of the leader sequence (which during clusterin biosynthesis facilitates its proper post-translational processing and secretion) in the functional activities of clusterin, a ubiquitous secretory glycoprotein with many biological functions, reported to be pro-apoptotic and anti-apoptotic in target cells, but for which the dual mechanism remains unclear.

语种英语
WOS记录号WOS:000238790900040
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63711
专题北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Hosp 1, Inst Urol, Beijing, Peoples R China
2.Northwestern Univ, Dept Urol, Feinberg Sch Med, Chicago, IL 60611 USA
3.Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA
4.Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA
5.Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA
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Zhang, Qiang,Zhou, Wei,Kundu, Shilajit,et al. The leader sequence triggers and enhances several functions of clusterin and is instrumental in the progression of human prostate cancer in vivo and in vitro[J]. BJU INTERNATIONAL,2006,98(2):452-460.
APA Zhang, Qiang.,Zhou, Wei.,Kundu, Shilajit.,Jang, Thomas L..,Yang, Ximing.,...&Lee, Chung.(2006).The leader sequence triggers and enhances several functions of clusterin and is instrumental in the progression of human prostate cancer in vivo and in vitro.BJU INTERNATIONAL,98(2),452-460.
MLA Zhang, Qiang,et al."The leader sequence triggers and enhances several functions of clusterin and is instrumental in the progression of human prostate cancer in vivo and in vitro".BJU INTERNATIONAL 98.2(2006):452-460.
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