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学科主题: 基础医学
题名:
Overexpression of Adiponectin Receptors Potentiates the Antiinflammatory Action of Subeffective Dose of Globular Adiponectin in Vascular Endothelial Cells
作者: Zhang, Peng; Wang, Ying; Fan, Yanbo; Tang, Zhihui; Wang, Nanping1
关键词: adiponectin ; endothelium ; adhesion molecule ; gene expression ; diabetes
刊名: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
发表日期: 2009
DOI: 10.1161/ATVBAHA.108.178061
卷: 29, 期:1, 页:67-U180
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: INFLAMMATORY ADHESION MOLECULES ; ACTIVATED PROTEIN-KINASE ; INSULIN-RESISTANCE ; PLASMA-PROTEIN ; DEFICIENT MICE ; EXPRESSION ; ATHEROSCLEROSIS ; PATHWAY ; ALPHA ; GAMMA
英文摘要:

Objective-A decreased plasma level of adiponectin is associated with obesity and metabolic syndrome and correlated with endothelial dysfunction. This study aimed to investigate the regulated expression of the newly identified adiponectin receptors (AdipoR1 and 2) and their roles in the endothelial expression of intercellular adhesion molecule-1 (ICAM-1) in response to tumor necrosis factor (TNF)-alpha.

Methods and Results-Immunohistochemical study and quantitative RT-PCR demonstrated that globular adiponectin suppressed the TNF-alpha-induced ICAM-1 expression in a dose-dependent manner in mouse aorta and human umbilical vein endothelial cells (HUVECs). Adenovirus-mediated overexpression of AdipoR1 and 2 in ECs significantly enhanced the suppressive effect of a subeffective dose of adiponectin on TNF-alpha-induced ICAM-1 expression and NF-kappa B activation. Promoter reporter assays and small interfering RNA revealed that peroxisome proliferator-activated receptor-alpha may function as an important pathway downstream of adiponectin and its receptors. Furthermore, overexpression of AdipoRs in rat carotid arteries markedly decreased the induction of ICAM-1 in vivo.

Conclusions-We provide novel evidence that upregulation of AdipoRs in ECs potentiates the antiinflammatory effect of adiponectin; modulating adiponectin receptors may have potential therapeutic applications for cardiovascular complications associated with metabolic syndrome and diabetes. (Arterioscler Thromb Vasc Biol. 2009; 29: 67-74.)

语种: 英语
所属项目编号: 30470810 ; 30890041 ; 30821001 ; 2006CB503906
项目资助者: National Natural Science Foundation of China ; Major National Basic Research Program of China
WOS记录号: WOS:000261797200013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63712
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Ctr Diabet, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, Peng,Wang, Ying,Fan, Yanbo,et al. Overexpression of Adiponectin Receptors Potentiates the Antiinflammatory Action of Subeffective Dose of Globular Adiponectin in Vascular Endothelial Cells[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,2009,29(1):67-U180.
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