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学科主题基础医学
Overexpression of Adiponectin Receptors Potentiates the Antiinflammatory Action of Subeffective Dose of Globular Adiponectin in Vascular Endothelial Cells
Zhang, Peng; Wang, Ying; Fan, Yanbo; Tang, Zhihui; Wang, Nanping1
关键词adiponectin endothelium adhesion molecule gene expression diabetes
刊名ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
2009
DOI10.1161/ATVBAHA.108.178061
29期:1页:67-U180
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
资助者National Natural Science Foundation of China ; Major National Basic Research Program of China ; National Natural Science Foundation of China ; Major National Basic Research Program of China
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]INFLAMMATORY ADHESION MOLECULES ; ACTIVATED PROTEIN-KINASE ; INSULIN-RESISTANCE ; PLASMA-PROTEIN ; DEFICIENT MICE ; EXPRESSION ; ATHEROSCLEROSIS ; PATHWAY ; ALPHA ; GAMMA
英文摘要

Objective-A decreased plasma level of adiponectin is associated with obesity and metabolic syndrome and correlated with endothelial dysfunction. This study aimed to investigate the regulated expression of the newly identified adiponectin receptors (AdipoR1 and 2) and their roles in the endothelial expression of intercellular adhesion molecule-1 (ICAM-1) in response to tumor necrosis factor (TNF)-alpha.

Methods and Results-Immunohistochemical study and quantitative RT-PCR demonstrated that globular adiponectin suppressed the TNF-alpha-induced ICAM-1 expression in a dose-dependent manner in mouse aorta and human umbilical vein endothelial cells (HUVECs). Adenovirus-mediated overexpression of AdipoR1 and 2 in ECs significantly enhanced the suppressive effect of a subeffective dose of adiponectin on TNF-alpha-induced ICAM-1 expression and NF-kappa B activation. Promoter reporter assays and small interfering RNA revealed that peroxisome proliferator-activated receptor-alpha may function as an important pathway downstream of adiponectin and its receptors. Furthermore, overexpression of AdipoRs in rat carotid arteries markedly decreased the induction of ICAM-1 in vivo.

Conclusions-We provide novel evidence that upregulation of AdipoRs in ECs potentiates the antiinflammatory effect of adiponectin; modulating adiponectin receptors may have potential therapeutic applications for cardiovascular complications associated with metabolic syndrome and diabetes. (Arterioscler Thromb Vasc Biol. 2009; 29: 67-74.)

语种英语
所属项目编号30470810 ; 30890041 ; 30821001 ; 2006CB503906
资助者National Natural Science Foundation of China ; Major National Basic Research Program of China ; National Natural Science Foundation of China ; Major National Basic Research Program of China
WOS记录号WOS:000261797200013
Citation statistics
Cited Times:46[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63712
Collection北京大学基础医学院_心血管所
作者单位1.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Ctr Diabet, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Peng,Wang, Ying,Fan, Yanbo,et al. Overexpression of Adiponectin Receptors Potentiates the Antiinflammatory Action of Subeffective Dose of Globular Adiponectin in Vascular Endothelial Cells[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,2009,29(1):67-U180.
APA Zhang, Peng,Wang, Ying,Fan, Yanbo,Tang, Zhihui,&Wang, Nanping.(2009).Overexpression of Adiponectin Receptors Potentiates the Antiinflammatory Action of Subeffective Dose of Globular Adiponectin in Vascular Endothelial Cells.ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,29(1),67-U180.
MLA Zhang, Peng,et al."Overexpression of Adiponectin Receptors Potentiates the Antiinflammatory Action of Subeffective Dose of Globular Adiponectin in Vascular Endothelial Cells".ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 29.1(2009):67-U180.
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