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学科主题: 精神卫生
题名:
No association of polymorphisms in the CDK5, NDEL1, and LIS1 with autism in Chinese Han population
作者: Wang, Lifang1,2; Li, Jun1,2; Jia, Meixiang1; Yue, Weihua1,2; Ruan, Yanyan1,2; Lu, Tianlan1,2; Zhang, Jishui3; Liu, Jing1; Zhang, Dai1,2
关键词: Autism ; CDK5 ; Association
刊名: PSYCHIATRY RESEARCH
发表日期: 2011-12-30
DOI: 10.1016/j.psychres.2011.08.004
卷: 190, 期:2-3, 页:369-371
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: CYCLIN-DEPENDENT KINASE-5 ; HOMEOBOX-TRANSCRIPTION-FACTOR ; REELIN GENE ALLELES ; SPECTRUM-DISORDER ; NEURONAL MIGRATION ; ENGRAILED-2 ; LINKAGE ; DISC1 ; LOCUS ; RISK
英文摘要:

Autism is a pervasive neurodevelopmental disorder. CDK5 (cyclin-dependent kinase 5) and its interacting molecules are involved in neurodevelopment. We performed a family-based association analysis between CDK5, NDEL1, and LIS1 polymorphisms and autism in a Chinese Han population. Our study did not detect a significant association. It indicated that common genetic variations in these genes might not play a role in the genetic predisposition to autism. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2010CB833905 ; 30870897 ; 81071110 ; 7081005
项目资助者: National Basic Research Program of China (973 program) ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000298722900037
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63714
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
3.Capital Univ Med Sci, Beijing Childrens Hosp, Beijing, Peoples R China

Recommended Citation:
Wang, Lifang,Li, Jun,Jia, Meixiang,et al. No association of polymorphisms in the CDK5, NDEL1, and LIS1 with autism in Chinese Han population[J]. PSYCHIATRY RESEARCH,2011,190(2-3):369-371.
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