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学科主题: 基础医学
题名:
From simple to complex: investigating the effects of lipid composition and phase on the membrane interactions of biomolecules using in situ atomic force microscopy
作者: Zhong, Jian1,2,3
刊名: INTEGRATIVE BIOLOGY
发表日期: 2011
DOI: 10.1039/c0ib00157k
卷: 3, 期:6, 页:632-644
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: GIANT UNILAMELLAR VESICLES ; SURFACE-PLASMON RESONANCE ; SCANNING PROBE MICROSCOPY ; SUPPORTED PLANAR BILAYERS ; PRION PROTEIN-FRAGMENT ; LIVING CELL-MEMBRANES ; GPI-ANCHORED PROTEINS ; BIOLOGICAL-MEMBRANES ; ANTIMICROBIAL PEPTIDES ; ALKALINE-PHOSPHATASE
英文摘要:

Biomembrane lipid composition and lateral heterogeneity vary significantly both spatially and temporally and have been shown to be associated with cell functions. Lipid raft-based membrane heterogeneity might be involved with cell physiological and pathological processes. Therefore, there is a great need to investigate the roles of lipid composition and lateral heterogeneity in membrane-related physiological and pathological processes. Supported lipid bilayers (SLBs) of increasing complexity are excellent membrane model systems to investigate the effects of lipid composition and phase on the membrane interactions of biomolecules. In situ AFM is a powerful tool to examine the dynamic interactions between SLBs and biomolecules on a nanoscale. Therefore, the in situ AFM measurements between SLBs of increasing complexity and biomolecules are excellent ways to investigate the effects of lipid composition and phase on the membrane-related processes. In this review, the following basic knowledge is first discussed: biomembrane lipid composition, lipid raft, lipid phase separation, SLBs, and AFM. Then the biological applications of in situ AFM to visualize the interactions between SLBs of increasing complexity and biomolecules are discussed.

语种: 英语
WOS记录号: WOS:000291317500002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63720
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Natl Engn Res Ctr Nanotechnol, Shanghai 200241, Peoples R China
2.Peking Univ, Biox Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Single Mol & Nanobiol Lab, Dept Biophys, Sch Basic Med Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhong, Jian. From simple to complex: investigating the effects of lipid composition and phase on the membrane interactions of biomolecules using in situ atomic force microscopy[J]. INTEGRATIVE BIOLOGY,2011,3(6):632-644.
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