IR@PKUHSC  > 北京大学基础医学院  > 生物物理学系
学科主题基础医学
From simple to complex: investigating the effects of lipid composition and phase on the membrane interactions of biomolecules using in situ atomic force microscopy
Zhong, Jian1,2,3
刊名INTEGRATIVE BIOLOGY
2011
DOI10.1039/c0ib00157k
3期:6页:632-644
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]GIANT UNILAMELLAR VESICLES ; SURFACE-PLASMON RESONANCE ; SCANNING PROBE MICROSCOPY ; SUPPORTED PLANAR BILAYERS ; PRION PROTEIN-FRAGMENT ; LIVING CELL-MEMBRANES ; GPI-ANCHORED PROTEINS ; BIOLOGICAL-MEMBRANES ; ANTIMICROBIAL PEPTIDES ; ALKALINE-PHOSPHATASE
英文摘要

Biomembrane lipid composition and lateral heterogeneity vary significantly both spatially and temporally and have been shown to be associated with cell functions. Lipid raft-based membrane heterogeneity might be involved with cell physiological and pathological processes. Therefore, there is a great need to investigate the roles of lipid composition and lateral heterogeneity in membrane-related physiological and pathological processes. Supported lipid bilayers (SLBs) of increasing complexity are excellent membrane model systems to investigate the effects of lipid composition and phase on the membrane interactions of biomolecules. In situ AFM is a powerful tool to examine the dynamic interactions between SLBs and biomolecules on a nanoscale. Therefore, the in situ AFM measurements between SLBs of increasing complexity and biomolecules are excellent ways to investigate the effects of lipid composition and phase on the membrane-related processes. In this review, the following basic knowledge is first discussed: biomembrane lipid composition, lipid raft, lipid phase separation, SLBs, and AFM. Then the biological applications of in situ AFM to visualize the interactions between SLBs of increasing complexity and biomolecules are discussed.

语种英语
WOS记录号WOS:000291317500002
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被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63720
专题北京大学基础医学院_生物物理学系
作者单位1.Natl Engn Res Ctr Nanotechnol, Shanghai 200241, Peoples R China
2.Peking Univ, Biox Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Single Mol & Nanobiol Lab, Dept Biophys, Sch Basic Med Sci, Beijing 100191, Peoples R China
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Zhong, Jian. From simple to complex: investigating the effects of lipid composition and phase on the membrane interactions of biomolecules using in situ atomic force microscopy[J]. INTEGRATIVE BIOLOGY,2011,3(6):632-644.
APA Zhong, Jian.(2011).From simple to complex: investigating the effects of lipid composition and phase on the membrane interactions of biomolecules using in situ atomic force microscopy.INTEGRATIVE BIOLOGY,3(6),632-644.
MLA Zhong, Jian."From simple to complex: investigating the effects of lipid composition and phase on the membrane interactions of biomolecules using in situ atomic force microscopy".INTEGRATIVE BIOLOGY 3.6(2011):632-644.
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