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学科主题: 精神卫生
题名:
Imbalance between Pro- and Anti-inflammatory Cytokines, and between Th1 and Th2 Cytokines in Depressed Patients: The Effect of Electroacupuncture or Fluoxetine Treatment
作者: Song, C.1; Halbreich, U.2; Han, C.3; Leonard, B. E.4; Luo, H.3
刊名: PHARMACOPSYCHIATRY
发表日期: 2009-09-01
DOI: 10.1055/s-0029-1202263
卷: 42, 期:5, 页:182-188
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: NECROSIS-FACTOR-ALPHA ; MAJOR DEPRESSION ; ANTIDEPRESSANT TREATMENT ; RECEPTOR ANTAGONIST ; IMMUNE ACTIVATION ; INTERFERON-GAMMA ; PLASMA-LEVELS ; TNF-ALPHA ; INTERLEUKIN-1-BETA ; DISORDERS
英文摘要:

Background: An increase in inflammatory response and an imbalance between T-helper (Th) 1 and 2 functions have been implicated in major depression. The aims of the present study were to 1) study the relationship between pro- and anti-inflammatory cytokines and between Th1 and Th2 produced cytokines in depressed patients and 2) evaluate and compare the effect of treatments with electroacupuncture (EA) and fluoxetine on these cytokines.

Methods: 95 outpatients with major depressive disorder were treated for 6 weeks with EA, fluoxetine or placebo. Hamilton Depression Rating Scale (HDRS) and Clinical Global Impression (CGI) were used to assess severity and therapeutic effects. 30 volunteers served as controls. Serum cytokine concentrations were measured by ELISA.

Results: Increased proinflammatory cytokine interleukin (IL)-1 beta and decreased anti-inflammatory cytokine IL-10 were found in the depressed patients. By contract, Th1 produced proinflammatory cytokines, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma were decreased, and Th2 produced cytokine IL-4 was significantly increased in depressed patients. The ratio of IFN/IL-4 was also increased. Both acupuncture and fluoxetine treatments, but not the placebo, reduced IL-1 beta concentrations in responders. However, only acupuncture attenuated TNF-alpha concentration and INF-gamma/IL-4 ratio towards the control level.

Discussion: These results suggest that an imbalance between the pro- and anti-inflammatory cytokines (IL-1 and IL-10), and between Th1 and Th2 cytokines (INF-gamma or TNF-alpha and IL-4) occurred in untreated depressed patients. Both EA and fluoxetine had an anti-inflammatory effect by reducing IL-1 beta. EA treatment also restored the balance between Th1 and Th2 systems by increasing TNF-alpha( and decreasing IL-4.

语种: 英语
项目资助者: Canadian Institutes for Health Research ; Amarin Neuroscience Ltd, UK
WOS记录号: WOS:000270507200003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63723
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing, Peoples R China
2.Univ Prince Edward Isl, Atlantic Vet Coll, Dept Biomed Sci, Neuroimmunol Res Lab, Charlottetown, PE C1A 4P3, Canada
3.SUNY Buffalo, Biobehav Program, Buffalo, NY 14260 USA
4.Univ Munich, Dept Psychiat & Psychotherapy, Laborsekt Psychoneuroimmunol, Munich, Germany

Recommended Citation:
Song, C.,Halbreich, U.,Han, C.,et al. Imbalance between Pro- and Anti-inflammatory Cytokines, and between Th1 and Th2 Cytokines in Depressed Patients: The Effect of Electroacupuncture or Fluoxetine Treatment[J]. PHARMACOPSYCHIATRY,2009,42(5):182-188.
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