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A pharmacogenomic study revealed an association between SLC6A4 and risperidone-induced weight gain in Chinese Han population
Wang, Fang1,2,3,8; Mi, Weifeng1,2,3; Ma, Wenbin4; Ma, Cuicui4; Yang, Yongfeng5,6; Zhang, Hongxing5,6; Du, Bo7; Li, Keqing7; Liu, Chenxing1,2,3; Wang, Lifang1,2,3; Lu, Tianlan1,2,3; Zhang, Hongyan1,2,3; Lv, Luxian5,6; Zhang, Dai1,2,3; Yue, Weihua1,2,3
关键词pharmacogenomic risperidone-induced weight gain serotonin transporter gene (solute carrier family 6, member 4, SLC6A4)
刊名PHARMACOGENOMICS
2015
DOI10.2217/pgs.15.133
16期:17页:1943-1949
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ANTIPSYCHOTIC-DRUGS ; CHRONIC-SCHIZOPHRENIA ; GENE POLYMORPHISMS ; RECEPTOR GENE ; HTR2C GENE ; METAANALYSIS ; OLANZAPINE ; OBESITY ; CLOZAPINE ; VARIANTS
英文摘要

Aim: We carried out a pharmacogenomic study in order to identify susceptible genes for antipsychotics induced weight gain within the Chinese Han population. Materials & methods: We enrolled 216 patients with schizophrenia in our study. All of them underwent risperidone monotherapy, and fulfilled 4-week follow-up. Weight gain was measured before treatment and 4 weeks later. Seven hundred and sixty-eight SNPs from 85 genes were calculated for association with weight gain percentage. Results: Fifty-seven SNPs located at 16 genes with a p-value less than 0.05.4 SNPs located on serotonin transporter gene (solute carrier family 6, member 4, SLC6A4) remained significant after multitest correction (rs3813034, p = 0.000357, q = 0.08, rs1042173, rs4325622, rs9303628, p = 0.000451, q = 0.08). Conclusion: SLC6A4 might be susceptible gene for risperidone-induced weight gain within the Chinese Han population.

语种英语
WOS记录号WOS:000365568700006
项目编号81222017 ; 8107088 ; 91232305 ; 2008AA02Z401 ; 2009AA022702
资助机构National Natural Science Foundation of China ; National High Technology Research and Development Program of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63731
专题北京大学精神卫生研究所
北京大学医学图书馆_采访编目部
北京大学第一临床医学院_妇产科
北京大学精神卫生研究所_精神科
北京大学精神卫生研究所_生化室
作者单位1.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Natl Clin Res Ctr Mental Hlth, Beijing 100191, Peoples R China
4.Jinzhou Kangning Hosp, Jinzhou 121013, Liaoning, Peoples R China
5.Xinxiang Med Univ, Affiliated Hosp 2, Dept Psychiat, Xinxiang 453002, Henan, Peoples R China
6.Henan Mental Hosp, Henan Key Lab Biol Psychiat, Xinxiang 453002, Henan, Peoples R China
7.Hebei Mental Hlth Ctr, Baoding 071000, Hebei, Peoples R China
8.Capital Med Univ, Beijing Childrens Hosp, Beijing 100191, Peoples R China
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GB/T 7714
Wang, Fang,Mi, Weifeng,Ma, Wenbin,et al. A pharmacogenomic study revealed an association between SLC6A4 and risperidone-induced weight gain in Chinese Han population[J]. PHARMACOGENOMICS,2015,16(17):1943-1949.
APA Wang, Fang.,Mi, Weifeng.,Ma, Wenbin.,Ma, Cuicui.,Yang, Yongfeng.,...&Yue, Weihua.(2015).A pharmacogenomic study revealed an association between SLC6A4 and risperidone-induced weight gain in Chinese Han population.PHARMACOGENOMICS,16(17),1943-1949.
MLA Wang, Fang,et al."A pharmacogenomic study revealed an association between SLC6A4 and risperidone-induced weight gain in Chinese Han population".PHARMACOGENOMICS 16.17(2015):1943-1949.
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