学科主题临床医学
A live birth of activated one-day-old unfertilized oocyte for a patient who experienced repeatedly near-total fertilization failure after intracytoplasmic sperm injection
Lu Qun1,3; Chen Xi1; Li Yang4; Zhang Xiao-hong2; Liang Rong1; Zhao Yong-ping1; Wei Li-hui2; Shen Huan1,3
关键词intracytoplasmic sperm injection fertilization failure oocyte activation calcium ionophore A23187
刊名CHINESE MEDICAL JOURNAL
2012-02-05
DOI10.3760/cma.j.issn.0366-6999.2012.03.028
125期:3页:546-548
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者Beijing Municipal Science &amp ; Technology Commission ; Beijing Municipal Science &amp ; Technology Commission
研究领域[WOS]General & Internal Medicine
关键词[WOS]CALCIUM IONOPHORE A23187 ; ICSI ; GLOBOZOOSPERMIA ; SPERMATOZOA ; CYCLES ; PLC
英文摘要

Total or near-total fertilization failure after intracytoplasmic sperm injection (ICSI) is a rare event, but it occurs repeatedly because of sperm defects in activating oocyte. The case presents a successful pregnancy and live birth after calcium ionophore A23187 (A23187) activation on one-day-old unfertilized oocytes in a patient whose husband suffered oligoasthenoteratozoospermia, and who had experienced repeated near-total fertilization failure after ICSI. In the second ICSI cycle, only one oocyte was fertilized while nine were unfertilized. Oocyte activation with A23187 were performed on the one-day-old unfertilized oocytes after ICSI and resulted in fertilization and embryo transfer. A clinical pregnancy was achieved and a healthy baby was born. To our knowledge, this is the first reported case of a healthy birth after oocyte activation on the one-day-old unfertilized oocyte. This indicates that "rescue oocyte activation" on one-day-old unfertilized oocytes after ICSI may be helpful for preventing total or near-total fertilization failure after ICSI. Chin Med J 2012;125(3):546-548

语种英语
所属项目编号Z111107058811028
资助者Beijing Municipal Science &amp ; Technology Commission ; Beijing Municipal Science &amp ; Technology Commission
WOS记录号WOS:000300749600028
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63732
专题北京大学第二临床医学院_计划生育与生殖医学科
作者单位1.Peking Univ, Peoples Hosp, Reprod Med Ctr, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100044, Peoples R China
3.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China
4.Shandong Univ, Shandong Prov Hosp, Ctr Reprod Med, Jinan 250021, Shandong, Peoples R China
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GB/T 7714
Lu Qun,Chen Xi,Li Yang,et al. A live birth of activated one-day-old unfertilized oocyte for a patient who experienced repeatedly near-total fertilization failure after intracytoplasmic sperm injection[J]. CHINESE MEDICAL JOURNAL,2012,125(3):546-548.
APA Lu Qun.,Chen Xi.,Li Yang.,Zhang Xiao-hong.,Liang Rong.,...&Shen Huan.(2012).A live birth of activated one-day-old unfertilized oocyte for a patient who experienced repeatedly near-total fertilization failure after intracytoplasmic sperm injection.CHINESE MEDICAL JOURNAL,125(3),546-548.
MLA Lu Qun,et al."A live birth of activated one-day-old unfertilized oocyte for a patient who experienced repeatedly near-total fertilization failure after intracytoplasmic sperm injection".CHINESE MEDICAL JOURNAL 125.3(2012):546-548.
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