北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Distinctive Effects of Carvedilol in the Non-infarct Zone: Remodelling of the Ligated Rat Heart Linked to Oxidative Stress
作者: Zhuang, X. F.1; Yin, C. Q.2; Wang, H. Y.1; Sun, N. L.1
关键词: MYOCARDIAL INFARCTION ; VENTRICULAR REMODELLING ; CARVEDILOL ; METOPROLOL ; OXIDATIVE STRESS ; COLLAGENASES
刊名: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
发表日期: 2009-09-01
卷: 37, 期:5, 页:1354-1364
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: MYOCARDIAL-INFARCTION ; ANGIOTENSIN-II ; IN-VITRO ; KAPPA-B ; FAILURE ; ANTIOXIDANT ; INHIBITION ; EXPRESSION ; METOPROLOL ; DYSFUNCTION
英文摘要:

In this study, an experimental rat ligated heart model was used to observe the effect of treatment with carvedilol, metoprolol and metoprolol plus a highly selective a,adrenergic blocking agent, bunazosin, after acute myocardial infarction. (MI). Compared with an untreated MI group, all drug-treated groups demonstrated attenuation of inflammatory mediators, activation of nuclear factor-kappa B (NF-kappa B), and increased levels of mRNA and active protein for the collagenases matrix metallopeptidase (MMP)-8 and MMP-13 in the non-infarct zone of the ventricle, as well as inhibition of the increase of left ventricular end-diastolic pressure. Supplementation of metoprolol with bunazosin did not add greatly to the effects of metoprolol alone. Of the three drug treatments, carvedilol showed a uniquely potent antioxidant activity that may strengthen its capacity to inhibit oxidative stress, the release of inflammatory mediators and activation of NF-kappa B. This study may help provide a mechanistic explanation for the greater benefits shown by carvedilol compared with metoprolol in treating heart failure.

语种: 英语
WOS记录号: WOS:000273133200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63737
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
2.Capital Univ Med Sci, Beijing Anzhen Hosp, Emergency Ctr, Beijing, Peoples R China

Recommended Citation:
Zhuang, X. F.,Yin, C. Q.,Wang, H. Y.,et al. Distinctive Effects of Carvedilol in the Non-infarct Zone: Remodelling of the Ligated Rat Heart Linked to Oxidative Stress[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2009,37(5):1354-1364.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhuang, X. F.]'s Articles
[Yin, C. Q.]'s Articles
[Wang, H. Y.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhuang, X. F.]‘s Articles
[Yin, C. Q.]‘s Articles
[Wang, H. Y.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace