IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科
学科主题临床医学
Distinctive Effects of Carvedilol in the Non-infarct Zone: Remodelling of the Ligated Rat Heart Linked to Oxidative Stress
Zhuang, X. F.1; Yin, C. Q.2; Wang, H. Y.1; Sun, N. L.1
关键词MYOCARDIAL INFARCTION VENTRICULAR REMODELLING CARVEDILOL METOPROLOL OXIDATIVE STRESS COLLAGENASES
刊名JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
2009-09-01
37期:5页:1354-1364
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]MYOCARDIAL-INFARCTION ; ANGIOTENSIN-II ; IN-VITRO ; KAPPA-B ; FAILURE ; ANTIOXIDANT ; INHIBITION ; EXPRESSION ; METOPROLOL ; DYSFUNCTION
英文摘要

In this study, an experimental rat ligated heart model was used to observe the effect of treatment with carvedilol, metoprolol and metoprolol plus a highly selective a,adrenergic blocking agent, bunazosin, after acute myocardial infarction. (MI). Compared with an untreated MI group, all drug-treated groups demonstrated attenuation of inflammatory mediators, activation of nuclear factor-kappa B (NF-kappa B), and increased levels of mRNA and active protein for the collagenases matrix metallopeptidase (MMP)-8 and MMP-13 in the non-infarct zone of the ventricle, as well as inhibition of the increase of left ventricular end-diastolic pressure. Supplementation of metoprolol with bunazosin did not add greatly to the effects of metoprolol alone. Of the three drug treatments, carvedilol showed a uniquely potent antioxidant activity that may strengthen its capacity to inhibit oxidative stress, the release of inflammatory mediators and activation of NF-kappa B. This study may help provide a mechanistic explanation for the greater benefits shown by carvedilol compared with metoprolol in treating heart failure.

语种英语
WOS记录号WOS:000273133200010
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63737
专题北京大学第二临床医学院_心血管内科
作者单位1.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
2.Capital Univ Med Sci, Beijing Anzhen Hosp, Emergency Ctr, Beijing, Peoples R China
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GB/T 7714
Zhuang, X. F.,Yin, C. Q.,Wang, H. Y.,et al. Distinctive Effects of Carvedilol in the Non-infarct Zone: Remodelling of the Ligated Rat Heart Linked to Oxidative Stress[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2009,37(5):1354-1364.
APA Zhuang, X. F.,Yin, C. Q.,Wang, H. Y.,&Sun, N. L..(2009).Distinctive Effects of Carvedilol in the Non-infarct Zone: Remodelling of the Ligated Rat Heart Linked to Oxidative Stress.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,37(5),1354-1364.
MLA Zhuang, X. F.,et al."Distinctive Effects of Carvedilol in the Non-infarct Zone: Remodelling of the Ligated Rat Heart Linked to Oxidative Stress".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 37.5(2009):1354-1364.
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