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SATB1 overexpression promotes malignant T-cell proliferation in cutaneous CD30(+) lymphoproliferative disease by repressing p21
Wang, Yang1; Gu, Xiaoguang1; Zhang, Gaolei1; Wang, Lin2; Wang, Tingting2; Zhao, Yun3; Zhang, Xiuyan3; Zhou, Youwen4; Kadin, Marshall5; Tu, Ping1
刊名BLOOD
2014-05-29
DOI10.1182/blood-2013-10-534693
123期:22页:3452-3461
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]BINDING-PROTEIN 1 ; LYMPHOMATOID PAPULOSIS ; GENE-EXPRESSION ; MYCOSIS-FUNGOIDES ; SEZARY-SYNDROME ; MULTIPLE GENES ; CANCER ; DISORDERS ; DIFFERENTIATION ; PROGRESSION
英文摘要

Cutaneous CD30(+) lymphoproliferative disease (CD30(+) LPD), characterized by the presence of CD30(+) anaplastic large T cells, comprises the second most common group of cutaneous T-cell lymphoma (CTCL). However, little is known about the pathobiology of the CD30(+) lymphoma cells, as well as the mechanisms of disease progression. Here we report that Special AT-rich region binding protein 1 (SATB1), a thymocyte specific chromatin organizer, is over-expressed in CD30(+) lymphoma cells in most CD30(+) LPDs, and its expression is upregulated during disease progression. Our findings show that SATB1 silencing in CD30(+) LPD cells leads to G1 cell cycle arrest mediated by p21 activation. Using chromatin immunoprecipitation, luciferase assays, and mutational analysis, we demonstrate that SATB1 directly regulates the transcription of p21 in a p53-independent manner. Moreover, DNA demethylation on a specific CpG-rich region of the SATB1 promoter is associated with the upregulation of SATB1 during disease progression. These experiments define a novel SATB1-p21 pathway in malignant CD30(+) T lymphocytes, which provides novel molecular insights into the pathogenesis of CD30(+) LPDs and possibly leads to new therapies.

语种英语
WOS记录号WOS:000342616600020
项目编号81072233 ; 81201228 ; 115138
资助机构National Nature Science Foundation of China ; Canadian Institute of Health Research
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63738
专题北京大学第一临床医学院
北京大学第一临床医学院_皮肤性病科
作者单位1.Peking Univ, Dept Dermatol & Venerol, Hosp 1, Beijing 100034, Peoples R China
2.Sichuan Univ, West China Hosp, Dept Dermatovenereol, Chengdu 610064, Sichuan, Peoples R China
3.Soochow Univ, Cyrus Tang Hematol Ctr, Suzhou, Peoples R China
4.Univ British Columbia, Dept Dermatol & Skin Sci, Vancouver, BC V5Z 1M9, Canada
5.Boston Univ, Sch Med, Dept Dermatol & Skin Surg, Roger Williams Med Ctr, Providence, RI USA
推荐引用方式
GB/T 7714
Wang, Yang,Gu, Xiaoguang,Zhang, Gaolei,et al. SATB1 overexpression promotes malignant T-cell proliferation in cutaneous CD30(+) lymphoproliferative disease by repressing p21[J]. BLOOD,2014,123(22):3452-3461.
APA Wang, Yang.,Gu, Xiaoguang.,Zhang, Gaolei.,Wang, Lin.,Wang, Tingting.,...&Tu, Ping.(2014).SATB1 overexpression promotes malignant T-cell proliferation in cutaneous CD30(+) lymphoproliferative disease by repressing p21.BLOOD,123(22),3452-3461.
MLA Wang, Yang,et al."SATB1 overexpression promotes malignant T-cell proliferation in cutaneous CD30(+) lymphoproliferative disease by repressing p21".BLOOD 123.22(2014):3452-3461.
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