学科主题基础医学
Distinct regulatory mechanism of immunoglobulin gene transcription in epithelial cancer cells
Zhu, Xiaohui1; Wu, Lina1; Zhang, Li1; Hao, Peng1; Zhang, Shuai1; Huang, Jing1; Zheng, Jie1; Liu, Yinan2; Li, Wenjun1; Zhang, Yingmei1; Zhou, Chunyan2; Zhang, Youhui3,4; Yin, C. Cameron5; Qiu, Xiaoyan1
关键词Ig gene transcription Oct-1 promoter transcription regulation VH4-59
刊名CELLULAR & MOLECULAR IMMUNOLOGY
2010-07-01
DOI10.1038/cmi.2010.13
7期:4页:279-287
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
资助者Natural Sciences Foundation, China ; Natural Sciences Foundation, China
研究领域[WOS]Immunology
关键词[WOS]CHAIN CONSTANT-REGION ; KAPPA-LIGHT-CHAIN ; HEAVY-CHAIN ; TUMOR-CELLS ; EXPRESSION ; PROMOTER ; COACTIVATOR ; OBF-1 ; E2A ; ACTIVATION
英文摘要

The restriction of immunoglobulin (Ig) expression to B lymphocytes is well established. However, several reports have confirmed that the Ig gene can be expressed in many non-B cancer cells and/or some normal cells. Our aim is to determine whether the Ig gene promoter can be activated in non-B cancer cells and to identify the regulatory mechanism for Ig gene expression. Our results show that the Ig promoter of VH4-59 was activated in several non-B cancer cell lines. Moreover, two novel positive regulatory elements, an enhancer-like element at -800 to -610 bp and a copromoter-like element at -610 to -300 bp, were identified in two epithelial cancer cell lines, HeLa S3 and HT-29. The octamer element (5′-ATGCAAAT-3′) located in the Ig promoter, a crucial element for B-cell-derived Ig gene transcription, was also very important for non-B-cell-derived Ig gene transcription. More importantly, we confirmed that octamer-related protein-1 (Oct-1), but not Oct-2, was a crucial transcriptional factor for Ig gene transcription due to its ability to bind to the octamer element of the Ig promoter in epithelial cancer cells. These results suggested the presence of a distinct regulatory mechanism for Ig gene expression in non-B cancer cells. Cellular & Molecular Immunology (2010) 7, 279-287; doi:10.1038/cmi.2010.13; published online 17 May 2010

语种英语
所属项目编号30572094 ; 30772470
资助者Natural Sciences Foundation, China ; Natural Sciences Foundation, China
WOS记录号WOS:000279487500007
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63739
专题基础医学院_北京大学人类疾病基因研究中心
作者单位1.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Biochem, Beijing 100191, Peoples R China
3.Chinese Acad Med Sci, Inst Canc, Dept Immunol, Beijing 100021, Peoples R China
4.Peking Union Med Coll, Beijing 100021, Peoples R China
5.Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA
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GB/T 7714
Zhu, Xiaohui,Wu, Lina,Zhang, Li,et al. Distinct regulatory mechanism of immunoglobulin gene transcription in epithelial cancer cells[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2010,7(4):279-287.
APA Zhu, Xiaohui.,Wu, Lina.,Zhang, Li.,Hao, Peng.,Zhang, Shuai.,...&Qiu, Xiaoyan.(2010).Distinct regulatory mechanism of immunoglobulin gene transcription in epithelial cancer cells.CELLULAR & MOLECULAR IMMUNOLOGY,7(4),279-287.
MLA Zhu, Xiaohui,et al."Distinct regulatory mechanism of immunoglobulin gene transcription in epithelial cancer cells".CELLULAR & MOLECULAR IMMUNOLOGY 7.4(2010):279-287.
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