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Expression of the Parkinson′s disease protein DJ-1 during the differentiation of neural stem cells
Li, Shen; Sun, Yi; Zhao, Xin; Pu, Xiao-Ping1
关键词DJ-1 Neural stem cell Differentiation Parkinson&prime s disease Neuron Astrocyte
刊名BRAIN RESEARCH
2012-08-15
DOI10.1016/j.brainres.2012.05.022
1468页:84-93
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]SPINAL-CORD ; ASTROCYTES ; MOUSE ; PATHOPHYSIOLOGY ; NEUROGENESIS ; NEUROSPHERES ; PATHOGENESIS ; GENETICS ; BRAIN ; MODEL
英文摘要

DJ-1 is a key neuroprotective factor and its loss-of-function mutations cause an autosomal recessive, early-onset form of familial Parkinson′s disease at the chromosomal PARK7 locus. However, the expression of DJ-1 during the differentiation of neural stem cells has not been fully elucidated. In this study, we investigated the expression of DJ-1 quantitatively using fluorescence immunocytochemistry and flow cytometry for differentiated neural stem cells from the cortex of the 14-day mouse embryos. We found that DJ-1 was co-expressed with the neuron-specific enolase and glial fibrillary acidic proteins, and also its expression was significantly increased in neurons and astrocytes with a prolonged differentiation period. These findings strongly suggest that DJ-1 is closely associated with the differentiation of neural stem cells. (C) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000307860000007
项目编号20090001110069
资助机构research fund for the doctoral program of higher education of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63743
专题北京大学药学院
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Dept Mol & Cellular Pharmacol, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
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GB/T 7714
Li, Shen,Sun, Yi,Zhao, Xin,et al. Expression of the Parkinson′s disease protein DJ-1 during the differentiation of neural stem cells[J]. BRAIN RESEARCH,2012,1468:84-93.
APA Li, Shen,Sun, Yi,Zhao, Xin,&Pu, Xiao-Ping.(2012).Expression of the Parkinson′s disease protein DJ-1 during the differentiation of neural stem cells.BRAIN RESEARCH,1468,84-93.
MLA Li, Shen,et al."Expression of the Parkinson′s disease protein DJ-1 during the differentiation of neural stem cells".BRAIN RESEARCH 1468(2012):84-93.
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