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学科主题: 药学
题名:
Expression of the Parkinson′s disease protein DJ-1 during the differentiation of neural stem cells
作者: Li, Shen; Sun, Yi; Zhao, Xin; Pu, Xiao-Ping1
关键词: DJ-1 ; Neural stem cell ; Differentiation ; Parkinson&prime ; s disease ; Neuron ; Astrocyte
刊名: BRAIN RESEARCH
发表日期: 2012-08-15
DOI: 10.1016/j.brainres.2012.05.022
卷: 1468, 页:84-93
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: SPINAL-CORD ; ASTROCYTES ; MOUSE ; PATHOPHYSIOLOGY ; NEUROGENESIS ; NEUROSPHERES ; PATHOGENESIS ; GENETICS ; BRAIN ; MODEL
英文摘要:

DJ-1 is a key neuroprotective factor and its loss-of-function mutations cause an autosomal recessive, early-onset form of familial Parkinson′s disease at the chromosomal PARK7 locus. However, the expression of DJ-1 during the differentiation of neural stem cells has not been fully elucidated. In this study, we investigated the expression of DJ-1 quantitatively using fluorescence immunocytochemistry and flow cytometry for differentiated neural stem cells from the cortex of the 14-day mouse embryos. We found that DJ-1 was co-expressed with the neuron-specific enolase and glial fibrillary acidic proteins, and also its expression was significantly increased in neurons and astrocytes with a prolonged differentiation period. These findings strongly suggest that DJ-1 is closely associated with the differentiation of neural stem cells. (C) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 20090001110069
项目资助者: research fund for the doctoral program of higher education of China
WOS记录号: WOS:000307860000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63743
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Dept Mol & Cellular Pharmacol, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Li, Shen,Sun, Yi,Zhao, Xin,et al. Expression of the Parkinson′s disease protein DJ-1 during the differentiation of neural stem cells[J]. BRAIN RESEARCH,2012,1468:84-93.
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