IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Morphine promotes apoptosis via TLR2, and this is negatively regulated by beta-arrestin 2
Li, Yi1,6; Sun, XiuLi1,2; Zhang, Yi1; Huang, JingJing3; Hanley, Gregory4; Ferslew, Kenneth E.5; Peng, Ying1,6; Yin, DeLing1,5
关键词Morphine Toll-like receptor 2 beta-Arrestin 2 Apoptosis
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2009-01-23
DOI10.1016/j.bbrc.2008.12.001
378期:4页:857-861
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
资助者National Institutes of Health (NIB) ; East Tennessee State University Research Development Committee (ETSU RDC) ; National Institutes of Health (NIB) ; East Tennessee State University Research Development Committee (ETSU RDC)
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]TOLL-LIKE RECEPTORS ; ACTIVATION ; MICROGLIA ; TOLERANCE ; NEURONS ; CELLS ; INHIBITION ; MECHANISM ; PATHWAYS ; PROTEINS
英文摘要

We have previously reported that morphine induces apoptosis. However, the underlying molecular mechanisms remain to be elucidated. Toll-like receptor 2 (TLR2), a key immune receptor in the TLR family, modulates cell survival and cell death in various systems. Evidence indicates that beta-arrestin 2 acts as a negative regulator of innate immune activation by TLRs. Here, we investigated the roles of TLR2, the downstreaming mediator MyD88, and beta-arrestin 2 in morphine-induced apoptosis. We showed that overexpression of TLR2 in HEK293 cells caused a significant increase in apoptosis after morphine treatment. Inhibition of MyD88 by transfecting dominant negative MyD88 or overexpression of beta-arrestin 2 by transfecting beta-arrestin 2 full length plasmid in TLR2 overexpressing HEK293 cells attenuated morphine-induced apoptosis. Our study thus demonstrates that TLR2 signaling mediates the morphine-induced apoptosis, and beta-arrestin 2 is a negative regulator in morphine-induced, TLR2-mediated apoptosis. (C) 2008 Elsevier Inc. All rights reserved.

语种英语
所属项目编号DA020120 ; 0048 ; 07-026M
资助者National Institutes of Health (NIB) ; East Tennessee State University Research Development Committee (ETSU RDC) ; National Institutes of Health (NIB) ; East Tennessee State University Research Development Committee (ETSU RDC)
WOS记录号WOS:000262447400033
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63748
专题北京大学第二临床医学院
作者单位1.E Tennessee State Univ, James H Quillen Coll Med, Dept Internal Med, Johnson City, TN 37614 USA
2.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100044, Peoples R China
3.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, Guangzhou 510060, Guangdong, Peoples R China
4.E Tennessee State Univ, James H Quillen Coll Med, Dept Lab Anim Resources, Johnson City, TN 37614 USA
5.E Tennessee State Univ, James H Quillen Coll Med, Dept Pharmacol, Johnson City, TN 37614 USA
6.Sun Yat Sen Univ, Affiliated Hosp 2, Dept Neurol, Guangzhou 510120, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Li, Yi,Sun, XiuLi,Zhang, Yi,et al. Morphine promotes apoptosis via TLR2, and this is negatively regulated by beta-arrestin 2[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,378(4):857-861.
APA Li, Yi.,Sun, XiuLi.,Zhang, Yi.,Huang, JingJing.,Hanley, Gregory.,...&Yin, DeLing.(2009).Morphine promotes apoptosis via TLR2, and this is negatively regulated by beta-arrestin 2.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,378(4),857-861.
MLA Li, Yi,et al."Morphine promotes apoptosis via TLR2, and this is negatively regulated by beta-arrestin 2".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 378.4(2009):857-861.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Yi]的文章
[Sun, XiuLi]的文章
[Zhang, Yi]的文章
百度学术
百度学术中相似的文章
[Li, Yi]的文章
[Sun, XiuLi]的文章
[Zhang, Yi]的文章
必应学术
必应学术中相似的文章
[Li, Yi]的文章
[Sun, XiuLi]的文章
[Zhang, Yi]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。