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学科主题: 临床医学
题名:
Morphine promotes apoptosis via TLR2, and this is negatively regulated by beta-arrestin 2
作者: Li, Yi1,6; Sun, XiuLi1,2; Zhang, Yi1; Huang, JingJing3; Hanley, Gregory4; Ferslew, Kenneth E.5; Peng, Ying1,6; Yin, DeLing1,5
关键词: Morphine ; Toll-like receptor 2 ; beta-Arrestin 2 ; Apoptosis
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2009-01-23
DOI: 10.1016/j.bbrc.2008.12.001
卷: 378, 期:4, 页:857-861
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: TOLL-LIKE RECEPTORS ; ACTIVATION ; MICROGLIA ; TOLERANCE ; NEURONS ; CELLS ; INHIBITION ; MECHANISM ; PATHWAYS ; PROTEINS
英文摘要:

We have previously reported that morphine induces apoptosis. However, the underlying molecular mechanisms remain to be elucidated. Toll-like receptor 2 (TLR2), a key immune receptor in the TLR family, modulates cell survival and cell death in various systems. Evidence indicates that beta-arrestin 2 acts as a negative regulator of innate immune activation by TLRs. Here, we investigated the roles of TLR2, the downstreaming mediator MyD88, and beta-arrestin 2 in morphine-induced apoptosis. We showed that overexpression of TLR2 in HEK293 cells caused a significant increase in apoptosis after morphine treatment. Inhibition of MyD88 by transfecting dominant negative MyD88 or overexpression of beta-arrestin 2 by transfecting beta-arrestin 2 full length plasmid in TLR2 overexpressing HEK293 cells attenuated morphine-induced apoptosis. Our study thus demonstrates that TLR2 signaling mediates the morphine-induced apoptosis, and beta-arrestin 2 is a negative regulator in morphine-induced, TLR2-mediated apoptosis. (C) 2008 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: DA020120 ; 0048 ; 07-026M
项目资助者: National Institutes of Health (NIB) ; East Tennessee State University Research Development Committee (ETSU RDC)
WOS记录号: WOS:000262447400033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63748
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.E Tennessee State Univ, James H Quillen Coll Med, Dept Internal Med, Johnson City, TN 37614 USA
2.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100044, Peoples R China
3.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, Guangzhou 510060, Guangdong, Peoples R China
4.E Tennessee State Univ, James H Quillen Coll Med, Dept Lab Anim Resources, Johnson City, TN 37614 USA
5.E Tennessee State Univ, James H Quillen Coll Med, Dept Pharmacol, Johnson City, TN 37614 USA
6.Sun Yat Sen Univ, Affiliated Hosp 2, Dept Neurol, Guangzhou 510120, Guangdong, Peoples R China

Recommended Citation:
Li, Yi,Sun, XiuLi,Zhang, Yi,et al. Morphine promotes apoptosis via TLR2, and this is negatively regulated by beta-arrestin 2[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,378(4):857-861.
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