IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Asia-Pacific consensus on the management of gastroesophageal reflux disease: Update
Fock, Kwong Ming1; Talley, Nicholas J.2; Fass, Ronnie3; Goh, Khean Lee4; Katelaris, Peter5; Hunt, Richard6; Hongo, Michio7; Ang, Tling Leong1; Holtmann, Gerald8; Nandurkar, Sanjay9; Lin, San Ren10; Wong, Benjamin C. Y.11; Chan, Francis K. L.12; Rani, Abdul Aziz13; Bak, Young-Tae14; Sollano, Jose15; Ho, Lawrence K. Y.16; Manatsathit, Sathoporn17
关键词consensus erosive esophagitis non-erosive reflux disease
刊名JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2008
DOI10.1111/j.1440-1746.2007.05249.x
23期:1页:8-22
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]PROTON-PUMP INHIBITORS ; HELICOBACTER-PYLORI INFECTION ; RANDOMIZED CONTROLLED-TRIAL ; ON-DEMAND-THERAPY ; PROSPECTIVE FOLLOW-UP ; LONG-TERM MANAGEMENT ; LOW-DOSE RANITIDINE ; ESOPHAGEAL SPHINCTER FUNCTION ; CHRONIC POSTERIOR LARYNGITIS ; OBSTRUCTIVE SLEEP-APNEA
英文摘要

Background and Aims: Since the publication of the Asia-Pacific GERD consensus in 2004, more data concerning the epidemiology and management of gastroesophageal reflux disease (GERD) have emerged. An evidence based review and update was needed.

Methods: A multidisciplinary group developed consensus statements using the Delphi approach. Relevant data were presented, and the quality of evidence, strength of recommendation, and level of consensus were graded.

Results: GERD is increasing in frequency in Asia. Risk factors include older age, male sex, race, family history, higher socioeconomic status, increased body mass index, and smoking. Symptomatic response to a proton pump inhibitor (PPI) test is diagnostic in patients with typical symptoms if alarm symptoms are absent. A negative pH study off therapy excludes GERD if a PPI test fails. The role for narrow band imaging, capsule endoscopy, and wireless pH monitoring has not yet been undefined. Diagnostic strategies in Asia must consider coexistent gastric cancer and peptic ulcer. Weight loss and elevation of head of bed improve reflux symptoms. PPIs are the most effective medical treatment. On-demand therapy is appropriate for nonerosive reflux disease (NERD) patients. Patients with chronic cough, laryngitis, and typical GERD symptoms should be offered twice daily PPI therapy after excluding non-GERD etiologies. Fundoplication could be offered to GERD patients when an experienced surgeon is available. Endoscopic treatment of GERD should not be offered outside clinical trials.

Conclusions: Further studies are needed to clarify the role of newer diagnostic modalities and endoscopic therapy. Diagnostic strategies for GERD in Asia must consider coexistent gastric cancer and peptic ulcer. PPIs remain the cornerstone of therapy.

语种英语
WOS记录号WOS:000251671000005
引用统计
被引频次:110[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63750
专题北京大学第三临床医学院
作者单位1.McMaster Univ, Med Ctr, Hamilton, ON L8S 4L8, Canada
2.Tohoku Univ Hosp, Sendai, Miyagi, Japan
3.Royal Adelaide Hosp, Adelaide, SA 5000, Australia
4.Monash Univ, Melbourne, Vic 3004, Australia
5.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
6.Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China
7.Univ Indonesia, Jakarta, Indonesia
8.Korea Univ, Coll Med, Seoul 136701, South Korea
9.Univ Santo Tomas, Manila, Philippines
10.Natl Univ Singapore Hosp, Singapore 117548, Singapore
11.Siriraj Hosp, Bangkok, Thailand
12.Univ Malaya, Kuala Lumpur 59100, Malaysia
13.Univ Sydney, Sydney, NSW 2006, Australia
14.Changi Gen Hosp, Dept Med, Div Gastroenterol, Singapore 529889, Singapore
15.Mayo Clin, Coll Med, Rochester, NY USA
16.Univ Arizona, Hlth Sci Ctr, Tucson, AZ USA
17.Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Fock, Kwong Ming,Talley, Nicholas J.,Fass, Ronnie,et al. Asia-Pacific consensus on the management of gastroesophageal reflux disease: Update[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2008,23(1):8-22.
APA Fock, Kwong Ming.,Talley, Nicholas J..,Fass, Ronnie.,Goh, Khean Lee.,Katelaris, Peter.,...&Manatsathit, Sathoporn.(2008).Asia-Pacific consensus on the management of gastroesophageal reflux disease: Update.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,23(1),8-22.
MLA Fock, Kwong Ming,et al."Asia-Pacific consensus on the management of gastroesophageal reflux disease: Update".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 23.1(2008):8-22.
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