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The stress-inducible actin-interacting protein DRR1 shapes social behavior
Masana, Merce1; Su, Yun-Ai1,2,3; Liebl, Claudia1; Wang, Xiao-Dong1; Jansen, Lara1; Westerholz, Soeren1; Wagner, Klaus V.1; Labermaier, Christiana1; Scharf, Sebastian H.1; Santarelli, Sara1; Hartmann, Jakob1; Schmidt, Mathias V.1; Rein, Theo1; Mueller, Marianne B.1
关键词DRR1 Tu3A Fam107A Social behavior Glucocorticoids Stress Lateral septum Resilience Actin Mice
刊名PSYCHONEUROENDOCRINOLOGY
2014-10-01
DOI10.1016/j.psyneuen.2014.06.009
48页:98-110
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Neurosciences ; Psychiatry
研究领域[WOS]Endocrinology & Metabolism ; Neurosciences & Neurology ; Psychiatry
关键词[WOS]RENAL-CELL CARCINOMA ; LATERAL SEPTUM ; GENE-EXPRESSION ; RAT-BRAIN ; GLUCOCORTICOID-RECEPTORS ; VASOPRESSIN RECEPTOR ; VENTRAL HIPPOCAMPUS ; SYNAPTIC EFFICACY ; DEFEAT STRESS ; OXYTOCIN
英文摘要

Understanding the molecular mechanisms by which stress is translated into changes in complex behavior may help to identify novel treatment strategies for stress-associated psychiatric disorders. The tumor suppressor gene down-regulated in renal cell carcinoma 1 (DRR1) was recently characterized as a new molecular link between stress, synaptic efficacy and behavioral performance, most likely through its ability to modulate actin dynamics.

The lateral septum is one of the brain regions prominently involved in the stress response. This brain region features high DRR1 expression in adult mice, even under basal conditions. We therefore aimed to characterize and dissect the functional role of septal DRR1 in modulating complex behavior. DRR1 protein expression was shown to be expressed in both neurons and astrocytes of the lateral septum of adult mice. Septal DRR1 mRNA expression increased after acute defeat stress and glucocorticoid receptor activation. To mimic the stress-induced DRR1 increase in the lateral septum of mice, we performed adenovirus-mediated region-specific overexpression of DRR1 and characterized the behavior of these mice. Overexpression of DRR1 in the septal region increased sociability, but did not change cognitive, anxiety-like or anhedonic behavior. The observed changes in social behavior did not involve alterations of the expression of vasopressin or oxytocin receptors, the canonical social neuropeptidergic circuits of the lateral septum.

In summary, our data suggest that the stress-induced increase of DRR1 expression in the lateral septum could be a protective mechanism to buffer or counterbalance negative consequences of stress exposure on social behavior. (C) 2014 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000340851000010
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被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63751
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Max Planck Inst Psychiat, D-80804 Munich, Germany
2.Peking Univ, Inst Mental Hlth, Beijing, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
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Masana, Merce,Su, Yun-Ai,Liebl, Claudia,et al. The stress-inducible actin-interacting protein DRR1 shapes social behavior[J]. PSYCHONEUROENDOCRINOLOGY,2014,48:98-110.
APA Masana, Merce.,Su, Yun-Ai.,Liebl, Claudia.,Wang, Xiao-Dong.,Jansen, Lara.,...&Mueller, Marianne B..(2014).The stress-inducible actin-interacting protein DRR1 shapes social behavior.PSYCHONEUROENDOCRINOLOGY,48,98-110.
MLA Masana, Merce,et al."The stress-inducible actin-interacting protein DRR1 shapes social behavior".PSYCHONEUROENDOCRINOLOGY 48(2014):98-110.
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