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学科主题: 基础医学
题名:
Expression of TMEM166 Protein in Human Normal and Tumor Tissues
作者: Xu, Dong1,2; Yang, Fan3; He, Huiying4; Hu, Jia1,2; Lv, Xiaodong1; Ma, Dalong1,2; Chen, Ying Yu1,2
关键词: TMEM166 ; tissue microarrays ; immunohistochemistry ; normal human tissues ; tumor tissues
刊名: APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
发表日期: 2013-12-01
DOI: 10.1097/PAI.0b013e31824e93d1
卷: 21, 期:6, 页:543-552
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Anatomy & Morphology ; Medical Laboratory Technology ; Pathology
研究领域[WOS]: Anatomy & Morphology ; Medical Laboratory Technology ; Pathology
关键词[WOS]: CELL-DEATH ; MOLECULAR-MECHANISMS ; AUTOPHAGY GENE ; SUPPRESSOR ; BECLIN-1 ; CANCER ; TUMORIGENESIS ; APOPTOSIS ; UVRAG
英文摘要:

Transmembrane protein 166 (TMEM166) is a novel human regulator involved in both autophagy and apoptosis. In this study, we generated a specific rabbit polyclonal antibody against human TMEM166 and assessed the expression of this protein in various human normal and tumor tissue samples by tissue microarray-based immunohistochemical analysis. Varying TMEM166 protein levels were expressed in a cell-type and tissue-type-specific manner in detected tissues or organs. Strong TMEM166 expression was shown in the glomerular zona of the adrenal cortex, chromophil cells of the pituitary gland, islet cells, squamous epithelium of the esophagus mucosa, the fundic gland, and hepatocytes. Moderate or weak TMEM166 staining was identified in the parathyroid gland, the testis, vaginal stratified squamous cells, lung macrophages, hematopoietic cells, renal tubular epithelial cells, macrophages in the spleen red pulp, and neuronal cells in the cerebral cortex. Some tissues failed to stain for TMEM166, such as adipose tissue, colon, cerebellum, lymph node, mammary gland, ovary, prostate, rectum, skin, small intestine, thyroid gland, tonsil, and thymus. In comparing human normal and tumor tissues, TMEM166 expression was widely downregulated in the cancer tissues. Our studies provide the basis for future investigations into cell-type-specific functions of this protein in human normal and tumor tissues.

语种: 英语
所属项目编号: 2011CB910103 ; 30771057
项目资助者: National Key Project for Basic Research of China (973) ; National Natural Science Foundation of China
WOS记录号: WOS:000327212100011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63754
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Minist Hlth, Key Lab Med Immunol, Beijing 100083, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Thorac Surg, Beijing 100083, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100083, Peoples R China

Recommended Citation:
Xu, Dong,Yang, Fan,He, Huiying,et al. Expression of TMEM166 Protein in Human Normal and Tumor Tissues[J]. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY,2013,21(6):543-552.
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