IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
Distribution of genotypes and antibiotic resistance genes among invasive Streptococcus agalactiae (group B streptococcus) isolates from Australasian patients belonging to different age groups
Zhao, Z.2; Kong, F.1; Zeng, X.3; Gidding, H. F.1; Morgan, J.4; Gilbert, G. L.1
关键词antibiotic resistance distribution group B streptococci mPCR/RLB serotypes Streptococcus agalactiae
刊名CLINICAL MICROBIOLOGY AND INFECTION
2008-03-01
DOI10.1111/j.1469-0691.2007.01914.x
14期:3页:260-267
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases ; Microbiology
研究领域[WOS]Infectious Diseases ; Microbiology
关键词[WOS]LINE BLOT HYBRIDIZATION ; ERYTHROMYCIN RESISTANCE ; MACROLIDE RESISTANCE ; ANTIMICROBIAL SUSCEPTIBILITY ; SEROTYPE IDENTIFICATION ; MULTIPLEX PCR ; MECHANISMS ; EPIDEMIOLOGY ; DISEASE ; VACCINE
英文摘要

Serotype distribution and antibiotic resistance (AR) among group B streptococci (GBS) affect GBS disease prevention strategies, but vary among patient groups. A multiplex PCR-based reverse line blot (mPCR/RLB) hybridisation assay was used to compare the distributions of GBS serotypes, serotype III subtypes and AR-associated genes among 666 invasive isolates from 663 patients, divided into five age groups: infants, early-onset (EO; 0-6 days) and late-onset (LO; 7-90 days); children (aged 3 months to 14 years); women of childbearing age (WCBA; aged 15-45 years); and other adults (males aged > 15 years; females aged > 45 years). Serotypes Ia and V and serosubtype III-1 accounted for 60% of infections. Serosubtype III-2, which corresponds to a virulent clone belonging to sequence type (ST)17, was relatively uncommon overall (7%), but was associated strongly with LO infant infections, in which it was significantly more common than in adult infections (25/104 (24%) vs. 9/392 (2%), p < 0.0001) or in EO infections (25/104 (24%) vs. 14/155 (9%), p < 0.005). Erythromycin resistance genes were found in 8% of all isolates (ermB 3%, ermA 2.5% and mefA/E 2%), in 11-15% of isolates of serotypes II and V and subtype III-1, but in none of the isolates of serosubtype III-2 (III-2, 0/49 vs. all others, 54/618 (9%), p < 0.04). In summary, the virulent serosubtype III-2 was associated strongly with LO infant GBS infection, but was less likely than other serotypes or serosubtype III-1 to carry AR genes.

语种英语
WOS记录号WOS:000252807300010
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63758
专题北京大学第一临床医学院_皮肤性病科
作者单位1.Westmead Hosp, ICPMR, Ctr Infect Dis & Microbiol CIDM Publ Hlth, Westmead, NSW 2145, Australia
2.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100871, Peoples R China
3.Wuhan First Hosp, Dept Dermatol, Res Lab Infect Skin Dis, Wuhan, Hubei Province, Peoples R China
4.Kenepuru Sci Ctr, ESR, Streptococcus Reference Lab, Porirua, New Zealand
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GB/T 7714
Zhao, Z.,Kong, F.,Zeng, X.,et al. Distribution of genotypes and antibiotic resistance genes among invasive Streptococcus agalactiae (group B streptococcus) isolates from Australasian patients belonging to different age groups[J]. CLINICAL MICROBIOLOGY AND INFECTION,2008,14(3):260-267.
APA Zhao, Z.,Kong, F.,Zeng, X.,Gidding, H. F.,Morgan, J.,&Gilbert, G. L..(2008).Distribution of genotypes and antibiotic resistance genes among invasive Streptococcus agalactiae (group B streptococcus) isolates from Australasian patients belonging to different age groups.CLINICAL MICROBIOLOGY AND INFECTION,14(3),260-267.
MLA Zhao, Z.,et al."Distribution of genotypes and antibiotic resistance genes among invasive Streptococcus agalactiae (group B streptococcus) isolates from Australasian patients belonging to different age groups".CLINICAL MICROBIOLOGY AND INFECTION 14.3(2008):260-267.
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