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学科主题: 临床医学
题名:
Distribution of genotypes and antibiotic resistance genes among invasive Streptococcus agalactiae (group B streptococcus) isolates from Australasian patients belonging to different age groups
作者: Zhao, Z.2; Kong, F.1; Zeng, X.3; Gidding, H. F.1; Morgan, J.4; Gilbert, G. L.1
关键词: antibiotic resistance ; distribution ; group B streptococci ; mPCR/RLB ; serotypes ; Streptococcus agalactiae
刊名: CLINICAL MICROBIOLOGY AND INFECTION
发表日期: 2008-03-01
DOI: 10.1111/j.1469-0691.2007.01914.x
卷: 14, 期:3, 页:260-267
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Microbiology
研究领域[WOS]: Infectious Diseases ; Microbiology
关键词[WOS]: LINE BLOT HYBRIDIZATION ; ERYTHROMYCIN RESISTANCE ; MACROLIDE RESISTANCE ; ANTIMICROBIAL SUSCEPTIBILITY ; SEROTYPE IDENTIFICATION ; MULTIPLEX PCR ; MECHANISMS ; EPIDEMIOLOGY ; DISEASE ; VACCINE
英文摘要:

Serotype distribution and antibiotic resistance (AR) among group B streptococci (GBS) affect GBS disease prevention strategies, but vary among patient groups. A multiplex PCR-based reverse line blot (mPCR/RLB) hybridisation assay was used to compare the distributions of GBS serotypes, serotype III subtypes and AR-associated genes among 666 invasive isolates from 663 patients, divided into five age groups: infants, early-onset (EO; 0-6 days) and late-onset (LO; 7-90 days); children (aged 3 months to 14 years); women of childbearing age (WCBA; aged 15-45 years); and other adults (males aged > 15 years; females aged > 45 years). Serotypes Ia and V and serosubtype III-1 accounted for 60% of infections. Serosubtype III-2, which corresponds to a virulent clone belonging to sequence type (ST)17, was relatively uncommon overall (7%), but was associated strongly with LO infant infections, in which it was significantly more common than in adult infections (25/104 (24%) vs. 9/392 (2%), p < 0.0001) or in EO infections (25/104 (24%) vs. 14/155 (9%), p < 0.005). Erythromycin resistance genes were found in 8% of all isolates (ermB 3%, ermA 2.5% and mefA/E 2%), in 11-15% of isolates of serotypes II and V and subtype III-1, but in none of the isolates of serosubtype III-2 (III-2, 0/49 vs. all others, 54/618 (9%), p < 0.04). In summary, the virulent serosubtype III-2 was associated strongly with LO infant GBS infection, but was less likely than other serotypes or serosubtype III-1 to carry AR genes.

语种: 英语
WOS记录号: WOS:000252807300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63758
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Westmead Hosp, ICPMR, Ctr Infect Dis & Microbiol CIDM Publ Hlth, Westmead, NSW 2145, Australia
2.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100871, Peoples R China
3.Wuhan First Hosp, Dept Dermatol, Res Lab Infect Skin Dis, Wuhan, Hubei Province, Peoples R China
4.Kenepuru Sci Ctr, ESR, Streptococcus Reference Lab, Porirua, New Zealand

Recommended Citation:
Zhao, Z.,Kong, F.,Zeng, X.,et al. Distribution of genotypes and antibiotic resistance genes among invasive Streptococcus agalactiae (group B streptococcus) isolates from Australasian patients belonging to different age groups[J]. CLINICAL MICROBIOLOGY AND INFECTION,2008,14(3):260-267.
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