学科主题基础医学
Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions
Liu, Liang1; Chen, Jiyun2,3; Yang, Bo1; Wang, Yonghua4
关键词Small heat shock protein (sHsp) Molecular chaperone Acid stress Temperature stress
刊名FEBS OPEN BIO
2015
DOI10.1016/j.fob.2015.02.006
5页:155-162
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]HEAT-SHOCK-PROTEIN ; ALPHA-B-CRYSTALLIN ; SULFOLOBUS-SOLFATARICUS ; MOLECULAR CHAPERONES ; SUBSTRATE-BINDING ; FLEXIBILITY ; PLASTICITY ; TRANSPORT ; DOMAIN ; HDEB
英文摘要

A great number of studies have proven that sHsps protect cells by inhibiting protein aggregation under heat stress, while little is known about their function to protect cells under acid stress. In this work, we show that Hsp20.1 and Hsp14.1 oligomers dissociated to smaller oligomeric species or even dimer/monomer at low pH (pH 4.0 and pH 2.0), whereas no prominent quaternary structural changes were seen at 50 degrees C. Both oligomers and smaller oligomeric species exhibited abilities to suppress client aggregation at low pH and at 50 degrees C. These results suggest that sHsps may function in different modes in different stressed conditions. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. This is an open access article under the CC BY-NC-ND license

语种英语
WOS记录号WOS:000366999300019
项目编号2014ZM0062 ; S2012040007734
资助机构Fundamental Research Funds for the Central Universities ; Natural Science Foundation of Guangdong Province
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63760
专题北京大学基础医学院_北京大学系统生物医学研究所
作者单位1.S China Univ Technol, Sch Biosci & Bioengn, Guangzhou 510006, Guangdong, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Inst Syst Biomed, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Biophys, Beijing 100191, Peoples R China
4.S China Univ Technol, Coll Light Ind & Food Sci, Guangzhou 510641, Guangdong, Peoples R China
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GB/T 7714
Liu, Liang,Chen, Jiyun,Yang, Bo,et al. Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions[J]. FEBS OPEN BIO,2015,5:155-162.
APA Liu, Liang,Chen, Jiyun,Yang, Bo,&Wang, Yonghua.(2015).Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions.FEBS OPEN BIO,5,155-162.
MLA Liu, Liang,et al."Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions".FEBS OPEN BIO 5(2015):155-162.
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