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学科主题: 临床医学
题名:
Analysis of copy number variations of BS69 in multiple types of hematological malignancies
作者: Yang, Hong2; Zhang, Chao3; Zhao, Xiaosu1; Wu, Qi3; Fu, Xinrong4; Yu, Bo3; Shao, Yong3; Guan, Ming5; Zhang, Wei6; Wan, Jun3,4,7; Huang, Xiaojun1
关键词: Copy number variations (CNVs) ; BS69 ; Hematological malignancies ; Acute myelogenous leukemia (AML) ; Acute lymphoblastic leukemia (ALL) ; Myelodysplastic syndrome (MDS)
刊名: ANNALS OF HEMATOLOGY
发表日期: 2010-10-01
DOI: 10.1007/s00277-010-0966-5
卷: 89, 期:10, 页:959-964
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: ADENOVIRUS E1A-ASSOCIATED PROTEIN ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; HUMAN GENOME ; GENE-EXPRESSION ; STRUCTURAL VARIATION ; CANCER ; DELETION ; PATHWAY ; DNA
英文摘要:

BS69 was originally identified as an adenovirus E1A-binding protein and was found to be involved in multiple cellular events. A recent array-based study implicated the presence of copy number variations (CNVs) of BS69 in the genomes of acute myelogenous leukemia. CNVs are present in the general population at varying degrees and have been found to associate with various types of diseases including hematological malignancies. However, most of the current studies focused on the genome-wide screening of CNVs, and the functional impact of such regions needs to be extensively investigated in large amount of clinical samples. Thus, in our study, we collected 617 bone marrow samples from multi-types of hematological malignancies as well as healthy controls. We found significant association between the CNVs of BS69 and these hematological malignancies including acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), multiple myeloma (MM), and myelodysplastic syndrome (MDS). We also examined the expression of BS69 mRNA in the samples with one or two copies of DNA, and observed a weak yet positive correlation between the relative expression level and gene dosage. In general, the CNVs of BS69 have the potential to serve as a diagnostic indicator, alone or in combination with other markers, for hematological malignancies.

语种: 英语
WOS记录号: WOS:000281161400002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63762
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Univ, Dept Hematol, Peoples Hosp, Inst Hematol, Beijing 100871, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Shenzhen, Guangdong, Peoples R China
3.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Guangdong, Peoples R China
4.Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Hong Kong, Peoples R China
5.Fudan Univ, Dept Lab Med, Cent Lab, Huashan Hosp, Shanghai 200433, Peoples R China
6.Ji Nan Univ, JNU HKUST Joint Lab, Guangzhou, Guangdong, Peoples R China
7.Shenzhen PKU HKUST Med Ctr, Shenzhen 518036, Guangdong, Peoples R China

Recommended Citation:
Yang, Hong,Zhang, Chao,Zhao, Xiaosu,et al. Analysis of copy number variations of BS69 in multiple types of hematological malignancies[J]. ANNALS OF HEMATOLOGY,2010,89(10):959-964.
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