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学科主题: 基础医学
题名:
The detection of (total and ccc) HBV DNA in liver transplant recipients with hepatitis B vaccine against HBV reinfection
作者: Duan, Bin-Wei1,2; Lu, Shi-Chun3; Lai, Wei4; Liu, Xue-En5,6; Liu, Yuan1,2
关键词: ccc DNA ; HBV reinfection ; hepatitis B ; liver transplantation ; HBV DNA ; vaccination
刊名: HUMAN VACCINES & IMMUNOTHERAPEUTICS
发表日期: 2015-10-03
卷: 11, 期:10, 页:2490-2494
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Immunology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Immunology
关键词[WOS]: HBIG PROPHYLAXIS ; VIRUS RECURRENCE ; CIRRHOSIS ; FAILURE ; DISEASE ; DISCONTINUATION ; IMMUNIZATION ; ADJUVANT ; STRATEGY ; THERAPY
英文摘要:

To investigate the levels of hepatitis B virus total DNA (HBV DNA) and covalently closed circular (ccc) DNA in liver transplant recipients who received hepatitis B vaccination, including responders and non-responders, following liver transplantation due to hepatitis B-related diseases and to investigate the efficacy of hepatitis B immune reconstitution against HBV reinfection. Twenty responders and 34 non-responders were enrolled in the present study. The levels of HBV total DNA and ccc DNA in peripheral blood mononuclear cells (PBMCs) and the liver and plasma were detected by real-time polymerase chain reaction (PCR). Fifty-three blood samples and 38 liver allograft tissues were acquired. For the responders, the mean serum titer for anti-HBs (antibodies against hepatitis B surface antigen) was 289 (46.64-1000) IU/ml. Also for the responders, HBV total DNA was detected in PBMCs for one recipient and in the liver for another recipient, but ccc DNA was not detected in either of those 2 recipients. For the non-responders, HBV total DNA was detected in PBMCS for 2 recipients, neither of whom had ccc DNA. Also for the non-responders, HBV total DNA was detected in the livers of 3 recipients, 2 of whom also had ccc DNA. All responders had discontinued hepatitis B immunoglobulin (HBIG), and 13 responders had discontinued antiviral agents. One responder experienced HBV recurrence during the follow-up period. For the majority of liver transplant recipients, no HBV total DNA or ccc DNA was detected in the blood or liver. The lack of HBV total DNA and ccc DNA both in PBMCs and the liver in liver transplant recipients who received hepatitis B vaccination to prevent HBV reinfection should be a prerequisite for the withdrawal of HBIG and/or antiviral agents.

语种: 英语
所属项目编号: 2011-2018-03 ; 2012BAI06B01
项目资助者: Capital Health Development Special Funds ; Ministry of Science and Technology Support Plan
WOS记录号: WOS:000361382100033
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63765
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Capital Med Univ, Beijing You An Hosp, Dept Hepatobiliary Surg, Beijing, Peoples R China
2.Capital Med Univ, Beijing You An Hosp, Liver Transplantat Program, Beijing, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Chinese PLA Med Sch, Key Lab Digital Hepatobiliary Surg Chinese PLA, Inst & Hosp Hepatobiliary Surg, Beijing, Peoples R China
4.Chengdu First Peoples Hosp, Dept Gen Surg, Chengdu, Sichuan, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Infect Dis Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Duan, Bin-Wei,Lu, Shi-Chun,Lai, Wei,et al. The detection of (total and ccc) HBV DNA in liver transplant recipients with hepatitis B vaccine against HBV reinfection[J]. HUMAN VACCINES & IMMUNOTHERAPEUTICS,2015,11(10):2490-2494.
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