IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
The detection of (total and ccc) HBV DNA in liver transplant recipients with hepatitis B vaccine against HBV reinfection
Duan, Bin-Wei1,2; Lu, Shi-Chun3; Lai, Wei4; Liu, Xue-En5,6; Liu, Yuan1,2
关键词ccc DNA HBV reinfection hepatitis B liver transplantation HBV DNA vaccination
刊名HUMAN VACCINES & IMMUNOTHERAPEUTICS
2015-10-03
11期:10页:2490-2494
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Immunology
研究领域[WOS]Biotechnology & Applied Microbiology ; Immunology
关键词[WOS]HBIG PROPHYLAXIS ; VIRUS RECURRENCE ; CIRRHOSIS ; FAILURE ; DISEASE ; DISCONTINUATION ; IMMUNIZATION ; ADJUVANT ; STRATEGY ; THERAPY
英文摘要

To investigate the levels of hepatitis B virus total DNA (HBV DNA) and covalently closed circular (ccc) DNA in liver transplant recipients who received hepatitis B vaccination, including responders and non-responders, following liver transplantation due to hepatitis B-related diseases and to investigate the efficacy of hepatitis B immune reconstitution against HBV reinfection. Twenty responders and 34 non-responders were enrolled in the present study. The levels of HBV total DNA and ccc DNA in peripheral blood mononuclear cells (PBMCs) and the liver and plasma were detected by real-time polymerase chain reaction (PCR). Fifty-three blood samples and 38 liver allograft tissues were acquired. For the responders, the mean serum titer for anti-HBs (antibodies against hepatitis B surface antigen) was 289 (46.64-1000) IU/ml. Also for the responders, HBV total DNA was detected in PBMCs for one recipient and in the liver for another recipient, but ccc DNA was not detected in either of those 2 recipients. For the non-responders, HBV total DNA was detected in PBMCS for 2 recipients, neither of whom had ccc DNA. Also for the non-responders, HBV total DNA was detected in the livers of 3 recipients, 2 of whom also had ccc DNA. All responders had discontinued hepatitis B immunoglobulin (HBIG), and 13 responders had discontinued antiviral agents. One responder experienced HBV recurrence during the follow-up period. For the majority of liver transplant recipients, no HBV total DNA or ccc DNA was detected in the blood or liver. The lack of HBV total DNA and ccc DNA both in PBMCs and the liver in liver transplant recipients who received hepatitis B vaccination to prevent HBV reinfection should be a prerequisite for the withdrawal of HBIG and/or antiviral agents.

语种英语
WOS记录号WOS:000361382100033
项目编号2011-2018-03 ; 2012BAI06B01
资助机构Capital Health Development Special Funds ; Ministry of Science and Technology Support Plan
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63765
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.Capital Med Univ, Beijing You An Hosp, Dept Hepatobiliary Surg, Beijing, Peoples R China
2.Capital Med Univ, Beijing You An Hosp, Liver Transplantat Program, Beijing, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Chinese PLA Med Sch, Key Lab Digital Hepatobiliary Surg Chinese PLA, Inst & Hosp Hepatobiliary Surg, Beijing, Peoples R China
4.Chengdu First Peoples Hosp, Dept Gen Surg, Chengdu, Sichuan, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Infect Dis Ctr, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Duan, Bin-Wei,Lu, Shi-Chun,Lai, Wei,et al. The detection of (total and ccc) HBV DNA in liver transplant recipients with hepatitis B vaccine against HBV reinfection[J]. HUMAN VACCINES & IMMUNOTHERAPEUTICS,2015,11(10):2490-2494.
APA Duan, Bin-Wei,Lu, Shi-Chun,Lai, Wei,Liu, Xue-En,&Liu, Yuan.(2015).The detection of (total and ccc) HBV DNA in liver transplant recipients with hepatitis B vaccine against HBV reinfection.HUMAN VACCINES & IMMUNOTHERAPEUTICS,11(10),2490-2494.
MLA Duan, Bin-Wei,et al."The detection of (total and ccc) HBV DNA in liver transplant recipients with hepatitis B vaccine against HBV reinfection".HUMAN VACCINES & IMMUNOTHERAPEUTICS 11.10(2015):2490-2494.
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