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学科主题: 基础医学
题名:
Ghrelin protects myocardium from isoproterenol-induced injury in rats
作者: Chang, L; Zhao, J; Li, GZ; Geng, B; Pan, CS; Qi, YF; Tang, CS
关键词: ghrelin ; hemodynamics ; endothelin-1 ; lactate dehydrogenase ; malondialdehyde ; isoproterenol ; heart ; rats
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2004-09-01
卷: 25, 期:9, 页:1131-1137
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: DYSFUNCTION ; TRANSPORT ; HUMANS ; SHOCK ; HEART
英文摘要:

AIM: To investigate the cardiac protective effects of ghrelin in rat with myocardial injury induced by isoproterenol (ISO). METHODS: Rats were subcutaneously injected ISO 40 mg(.)kg(-1.)d(-1) with or without ghrelin I or 10 nmol(.)kg(-1.)d(-1) for 2 d. Hemodynamic parameters including mean arterial blood pressure and left ventricular pressure were measured at 12 h after the last injection with ISO and/or ghrelin. Plasma lactate dehydrogenase (LDH) activity, plasma and myocardial contents of malondialdehyde (MDA), and conjugated diene were measured. Plasma ghrelin and endothelin-1 levels were assayed using radioimmunoassay methods. Endothelin-1 and ghrelin mRNA were determined using RT-PCR. RESULTS: About 45% (5111) of rats after treatment with ISO alone died during experimental periods. However, no rats died after administration with ghrelin 10 nmol(.)kg(-1.)d(-1)(0/11, P<0.05). Ghrelin also obviously ameliorated the hemodynamic disturbance in rats induced by ISO. The plasma LDH activity, contents of myocardial and plasma MDA, and conjugated diene level in plasma in ISO+G10 nmol(.)kg(-1.)d(-1) group were decreased by 28%, 34%, 73%, and 38% compared with those of ISO group (all P<0.01) respectively. ISO-induced endothelin-1 mRNA over-expression was inhibited and endothelin- 1 level in plasma were inhibited by ghrelin I and 10 nmol(.)kg(-1.)d(-1). The ghrelin levels in plasma and ghrelin mRNA in myocardium were increased in the rats after injection of ISO. The plasma ghrelin level was further increased after ghrelin administration. CONCLUSION: Ghrelin has a protective effect against ISO-induced myocardial injury.

语种: 英语
WOS记录号: WOS:000223900000005
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63773
Appears in Collections:基础医学院_生理学与病理生理学系_期刊论文

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作者单位: 1.Peking Univ, Dept Physiol, Beijing 100083, Peoples R China
2.Coll Med, Dept Ningxia, Yinchuan 750004, Peoples R China
3.Key Lab Cardiovasc Biol & Educ Minist, Beijing 100083, Peoples R China
4.1st Hosp Beijing, Inst Cardiovasc Dis Res, Beijing 100034, Peoples R China

Recommended Citation:
Chang, L,Zhao, J,Li, GZ,et al. Ghrelin protects myocardium from isoproterenol-induced injury in rats[J]. ACTA PHARMACOLOGICA SINICA,2004,25(9):1131-1137.
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