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pH-sensitive chitosan-derived nanoparticles as doxorubicin carriers for effective anti-tumor activity: preparation and in vitro evaluation
Jin, Yun-Huan1; Hu, Hai-Yang1; Qiao, Ming-Xi1; Zhu, Jia1; Qi, Jia-Wei1; Hu, Chan-Juan1; Zhang, Qiang2; Chen, Da-Wei1
关键词Chitosan derivatives pH-sensitive Nanoparticles Doxorubicin Drug resistance Antitumor activity
刊名COLLOIDS AND SURFACES B-BIOINTERFACES
2012-06-01
DOI10.1016/j.colsurfb.2012.01.032
94页:184-191
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
研究领域[WOS]Biophysics ; Chemistry ; Materials Science
关键词[WOS]SELF-ASSEMBLED NANOPARTICLES ; BEARING 5-BETA-CHOLANIC ACID ; GLYCOL CHITOSAN ; CARBOXYMETHYL-CHITOSAN ; MULTIDRUG-RESISTANCE ; POLYMERIC MICELLES ; PHYSICOCHEMICAL CHARACTERISTICS ; AGGREGATED NANOPARTICLES ; DRUG-RESISTANCE ; GENE DELIVERY
英文摘要

pH-sensitive self-aggregated nanoparticles (SNPs), based on amphiphilic deoxycholic acid (DOCA) modified carboxymethyl chitosan (DCMC), were prepared for delivery of the anticancer drug doxorubicin (DOX). DCMCs with different degrees of substitution (DS) of DOCA were initially synthesized and characterized. Based on self-aggregation, DCMC formed nanoparticles with size ranging from 87 to 174 nm. The critical aggregation concentration (CAC) decreased on increasing the DS of DOCA. Moreover, the DCMC SNPs showed an acidic pH-induced aggregation and deformation behavior. The DOX-loaded SNPs ([D]NP) exhibited a sustained drug release manner, which could be accelerated by an acidic pH, but delayed by a higher DS of DOCA. Antitumor efficacy results showed that [D]NP could suppress both sensitive and resistant MCF-7 cells effectively in a dose- and time-dependent manner. The enhanced cellular uptake and greater retention of [D]NP in drug-resistant cells, as evidenced by confocal microscopy and flow cytometry, contributed to a superior efficacy of [D]NP over free DOX. These results suggest the potential of DCMC SNPs as carriers for the hydrophobic drug DOX for effective cancer therapy against drug-resistant tumors. (C) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000302979900027
项目编号2009CB930300 ; 30801456 ; L 2010528
资助机构National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Educational Department of Liaoning Province
引用统计
被引频次:69[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63775
专题北京大学药学院_药剂学系
作者单位1.Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, Shenyang 110016, Liaoning Provin, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Jin, Yun-Huan,Hu, Hai-Yang,Qiao, Ming-Xi,et al. pH-sensitive chitosan-derived nanoparticles as doxorubicin carriers for effective anti-tumor activity: preparation and in vitro evaluation[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2012,94:184-191.
APA Jin, Yun-Huan.,Hu, Hai-Yang.,Qiao, Ming-Xi.,Zhu, Jia.,Qi, Jia-Wei.,...&Chen, Da-Wei.(2012).pH-sensitive chitosan-derived nanoparticles as doxorubicin carriers for effective anti-tumor activity: preparation and in vitro evaluation.COLLOIDS AND SURFACES B-BIOINTERFACES,94,184-191.
MLA Jin, Yun-Huan,et al."pH-sensitive chitosan-derived nanoparticles as doxorubicin carriers for effective anti-tumor activity: preparation and in vitro evaluation".COLLOIDS AND SURFACES B-BIOINTERFACES 94(2012):184-191.
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