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学科主题: 药学
题名:
pH-sensitive chitosan-derived nanoparticles as doxorubicin carriers for effective anti-tumor activity: preparation and in vitro evaluation
作者: Jin, Yun-Huan1; Hu, Hai-Yang1; Qiao, Ming-Xi1; Zhu, Jia1; Qi, Jia-Wei1; Hu, Chan-Juan1; Zhang, Qiang2; Chen, Da-Wei1
关键词: Chitosan derivatives ; pH-sensitive ; Nanoparticles ; Doxorubicin ; Drug resistance ; Antitumor activity
刊名: COLLOIDS AND SURFACES B-BIOINTERFACES
发表日期: 2012-06-01
DOI: 10.1016/j.colsurfb.2012.01.032
卷: 94, 页:184-191
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
研究领域[WOS]: Biophysics ; Chemistry ; Materials Science
关键词[WOS]: SELF-ASSEMBLED NANOPARTICLES ; BEARING 5-BETA-CHOLANIC ACID ; GLYCOL CHITOSAN ; CARBOXYMETHYL-CHITOSAN ; MULTIDRUG-RESISTANCE ; POLYMERIC MICELLES ; PHYSICOCHEMICAL CHARACTERISTICS ; AGGREGATED NANOPARTICLES ; DRUG-RESISTANCE ; GENE DELIVERY
英文摘要:

pH-sensitive self-aggregated nanoparticles (SNPs), based on amphiphilic deoxycholic acid (DOCA) modified carboxymethyl chitosan (DCMC), were prepared for delivery of the anticancer drug doxorubicin (DOX). DCMCs with different degrees of substitution (DS) of DOCA were initially synthesized and characterized. Based on self-aggregation, DCMC formed nanoparticles with size ranging from 87 to 174 nm. The critical aggregation concentration (CAC) decreased on increasing the DS of DOCA. Moreover, the DCMC SNPs showed an acidic pH-induced aggregation and deformation behavior. The DOX-loaded SNPs ([D]NP) exhibited a sustained drug release manner, which could be accelerated by an acidic pH, but delayed by a higher DS of DOCA. Antitumor efficacy results showed that [D]NP could suppress both sensitive and resistant MCF-7 cells effectively in a dose- and time-dependent manner. The enhanced cellular uptake and greater retention of [D]NP in drug-resistant cells, as evidenced by confocal microscopy and flow cytometry, contributed to a superior efficacy of [D]NP over free DOX. These results suggest the potential of DCMC SNPs as carriers for the hydrophobic drug DOX for effective cancer therapy against drug-resistant tumors. (C) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2009CB930300 ; 30801456 ; L 2010528
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Educational Department of Liaoning Province
WOS记录号: WOS:000302979900027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63775
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, Shenyang 110016, Liaoning Provin, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Jin, Yun-Huan,Hu, Hai-Yang,Qiao, Ming-Xi,et al. pH-sensitive chitosan-derived nanoparticles as doxorubicin carriers for effective anti-tumor activity: preparation and in vitro evaluation[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2012,94:184-191.
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