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学科主题: 临床医学
题名:
Differences in iris structural measurements among American Caucasians, American Chinese and mainland Chinese
作者: Wang, Dandan1,3; He, Mingguang1; Wu, Lingling2; Yaplee, Stephanie3; Singh, Kuldev4; Lin, Shan3
关键词: anterior segment optical coherence tomography ; ethnic difference ; iris ; pupil
刊名: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
发表日期: 2012-03-01
DOI: 10.1111/j.1442-9071.2011.02658.x
卷: 40, 期:2, 页:162-169
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: PRIMARY ANGLE-CLOSURE ; OPTICAL COHERENCE TOMOGRAPHY ; GLAUCOMA ; ASSOCIATION ; THICKNESS ; EYES
英文摘要:

Background: To assess the distribution of iris structural measurements among American Caucasians, American Chinese and mainland Chinese aged 40 years and over, in order to determine associated factors of increased risk for angle closure in Chinese.

Design: Prospective multicentre cross-sectional study. Participants: Four gender-and age-matched cohorts: Caucasians, American Chinese, Southern Chinese from Guangzhou and Northern Chinese from Beijing were enrolled in this study. Methods: Anterior segment optical coherence tomography was utilized to image the anterior chamber. Customized software was used to calculate the related parameters from anterior segment optical coherence tomography images.

Main Outcome Measures: Iris thickness at 750 mm from the scleral spur, iris curvature, iris area, pupil diameter.

Results: Data from 121, 124, 121 and 120 subjects were available for American Caucasian, American Chinese, Southern and Northern Mainland Chinese subjects, respectively. The Chinese cohorts did not differ with regard to any of the parameters. Multiple linear regressions indicated that Caucasians had thinner iris thickness at 750 mm from the scleral spur and smaller iris area than Chinese after controlling for potential confounders. Female Caucasians had thinner irides (P = 0.015) and smaller iris area (P = 0.001) than male Caucasians. Female Chinese tended to have more convex irides (P = 0.021) than male Chinese. Pupil size was inversely associated with age (P < 0.001) in both ethnicities.

Conclusions: In dark conditions, Chinese have thicker irides and greater iris area than Caucasians independent of pupil size. Among Chinese, more convex irides in women may account for the higher rate of narrow angles identified in this segment of the Chinese population.

语种: 英语
所属项目编号: EY002161
项目资助者: George and Rosalie Hearst Foreign Fellowship ; That Man May See, Inc. ; Research to Prevent Blindness ; NEI
WOS记录号: WOS:000301533200009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63781
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Ctr Eye, Beijing 100871, Peoples R China
2.Stanford Univ, Palo Alto, CA 94304 USA
3.Sun Yat Sen Univ, State Key Lab Ophthalmol, Zhongshan Ophthalm Ctr, Guangzhou 510275, Guangdong, Peoples R China
4.Univ Calif San Francisco, San Francisco, CA 94143 USA

Recommended Citation:
Wang, Dandan,He, Mingguang,Wu, Lingling,et al. Differences in iris structural measurements among American Caucasians, American Chinese and mainland Chinese[J]. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,2012,40(2):162-169.
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