学科主题基础医学
ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex
Mendoza, Michelle C.1; Er, E. Emrah1; Zhang, Wenjuan2; Ballif, Bryan A.3,4; Elliott, Hunter L.1,5; Danuser, Gaudenz1; Blenis, John1
刊名MOLECULAR CELL
2011-03-18
DOI10.1016/j.molcel.2011.02.031
41期:6页:661-671
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]PROTEIN-KINASE ; CELL MOTILITY ; GROWTH-FACTOR ; PAXILLIN PHOSPHORYLATION ; ACTIN POLYMERIZATION ; MYOSIN-II ; IN-VIVO ; ADHESION ; MEMBRANE ; DYNAMICS
英文摘要

Cell movement begins with a leading edge protrusion, which is stabilized by nascent adhesions and retracted by mature adhesions. The ERK-MAPK (extracellular signal-regulated kinase-mitogen-activated protein kinase) localizes to protrusions and adhesions, but how it regulates motility is not understood. We demonstrate that ERK controls protrusion initiation and protrusion speed. Lamellipodial protrusions are generated via the WRC (WAVE2 regulatory complex), which activates the Arp2/3 actin nucleator for actin assembly. The WRC must be phosphorylated to be activated, but the sites and kinases that regulate its intermolecular changes and membrane recruitment are unknown. We show that ERK colocalizes with the WRC at lamellipodial leading edges and directly phosphorylates two WRC components: WAVE2 and Abil. The, phosphorylations are required for functional WRC interaction with Arp2/3 and actin during cell protrusion. Thus, ERK coordinates adhesion disassembly with WRC activation and actin polymerization to promote productive leading edge advancement during cell migration.

语种英语
WOS记录号WOS:000288827500007
项目编号R37CA46595 ; P20 RR16462 ; U54GM64346
资助机构NCI ; Susan G. Komen PDF ; Vermont Genetics Network through NIH, NCRR ; NIH
引用统计
被引频次:67[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63785
专题北京大学基础医学院_北京大学人类疾病基因研究中心
作者单位1.Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
2.Univ Vermont, Dept Biol, Burlington, VT 05405 USA
3.Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
4.Peking Univ, Ctr Human Dis Genom, Dept Immunol, Beijing 100191, Peoples R China
5.Univ Vermont, Vermont Genet Network Prote Facil, Burlington, VT 05405 USA
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GB/T 7714
Mendoza, Michelle C.,Er, E. Emrah,Zhang, Wenjuan,et al. ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex[J]. MOLECULAR CELL,2011,41(6):661-671.
APA Mendoza, Michelle C..,Er, E. Emrah.,Zhang, Wenjuan.,Ballif, Bryan A..,Elliott, Hunter L..,...&Blenis, John.(2011).ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex.MOLECULAR CELL,41(6),661-671.
MLA Mendoza, Michelle C.,et al."ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex".MOLECULAR CELL 41.6(2011):661-671.
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