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学科主题: 临床医学
题名:
Doxazosin gastrointestinal therapeutic system versus tamsulosin for the treatment of benign prostatic hyperplasia: A study in Chinese patients
作者: Xue, Zhaoying; Zhang, Yuanfang; Ding, Qiang; He, Zhishong; Wang, Jiangong; Xu, Ke
关键词: benign prostatic hyperplasia ; China ; doxazosin ; gastrointestinal therapeutic system ; International Prostate Symptom Score ; tamsulosin
刊名: INTERNATIONAL JOURNAL OF UROLOGY
发表日期: 2007-02-01
DOI: 10.1111/j.1442-2042.2007.01502.x
卷: 14, 期:2, 页:118-122
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: URINARY-TRACT SYMPTOMS ; DOUBLE-BLIND ; CONTROLLED-RELEASE ; ALPHA(1)-ADRENOCEPTOR SELECTIVITY ; AMERICAN MEN ; EFFICACY ; PLACEBO ; OBSTRUCTION ; ANTAGONISTS ; TOLERABILITY
英文摘要:

Aim: The efficacy and safety profiles of two alpha(1)-adrenoceptor antagonists, doxazosin gastrointestinal therapeutic system, a controlled-release formulation of doxazosin, and tamsulosin, were compared in Chinese men with confirmed benign prostatic hyperplasia.

Methods: After a 2-week placebo run-in phase, 117 patients were randomized to daily treatment with doxazosin gastrointestinal therapeutic system (4 mg doxazosin) (n = 60) or 0.2 mg tamsulosin (n = 57) for 6 weeks with no titration of study medications. Efficacy was measured by the International Prostate Symptom Score, maximum urinary flow rate, postvoid residual urine volume, and quality-of-life score from the International Prostate Symptom Score. Adverse events were recorded.

Results: Both drugs significantly improved the International Prostate Symptom Score (total, irritative subscore and obstructive subscore) and maximum urinary flow rate. Doxazosin gastrointestinal therapeutic system reduced postvoid residual urine volume significantly more than tamsulosin (-25 +/- 5 mL vs 2 +/- 5 mL, P = 0.041) in patients with residual volume > 0 mL at baseline. Other differences between groups were not statistically significant.

Conclusions: The doxazosin gastrointestinal therapeutic system and tamsulosin were effective and well tolerated for the treatment of benign prostatic hyperplasia in Chinese men.

语种: 英语
WOS记录号: WOS:000243534000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63786
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Inst Urol, Beijing 100034, Peoples R China
2.Fudan Univ, Shanghai Huashan Hosp, Dept Urol, Shanghai, Peoples R China

Recommended Citation:
Xue, Zhaoying,Zhang, Yuanfang,Ding, Qiang,et al. Doxazosin gastrointestinal therapeutic system versus tamsulosin for the treatment of benign prostatic hyperplasia: A study in Chinese patients[J]. INTERNATIONAL JOURNAL OF UROLOGY,2007,14(2):118-122.
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